Bimzelx (bimekizumab or bimekizumab bkzx) is an injectable medication that's used to treat plaque psoriasis in adults. It's a monoclonal antibody that belongs to a class called interleukin antagonists. This medication is available as prefilled autoinjectors and prefilled syringes. It's injected under the skin of the belly, thighs, or the back of the upper arm. Bimzelx (bimekizumab) is typically injected every month at the beginning, and then every other month as you continue taking the medication. Common side effects include runny nose, cough, and oral thrush.
Moderate-to-severe plaque psoriasis in adults
Bimzelx (bimekizumab) is a monoclonal antibody known as an interleukin receptor antagonist. It blocks interleukin-17A and interleukin-17F (IL-17A, IL-17F), which are proteins that are part of your immune system and are responsible for inflammation (redness and swelling).
By blocking these proteins, Bimzelx (bimekizumab) calms down the immune system. As a result, it can help ease symptoms of itchy skin and skin redness due to plaque psoriasis.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Dosing is every month or every other month, so it's convenient for most people
Good option for psoriasis if topical medications have stopped working
Available as prefilled autoinjectors and prefilled syringes
Can cause injection reactions, such as pain, bruising, and swelling
Might raise the risk of infections
Unknown if safe or works well during pregnancy or while breastfeeding
Consider getting all your scheduled vaccines before you start treatment with Bimzelx (bimekizumab). It's not known how this medication affects how well vaccines work or how safe they are for you. But it's best to avoid live vaccines while you're taking Bimzelx (bimekizumab). Talk with your provider or pharmacist if you're due for a vaccine or if you're not sure which vaccines are safe for you.
Let your provider or pharmacist know what medications you're taking, including over-the-counter products and supplements. Bimzelx (bimekizumab) can interact with some medications, so your providers can check that your medications are safe to take together. Ask your provider or pharmacist if you have any questions about interactions with Bimzelx (bimekizumab).
Store Bimzelx (bimekizumab) in the refrigerator in its original container and away from light; throw it away once it's past the written expiration date on the carton.
You can also keep Bimzelx (bimekizumab) at room temperature (up to 77°F) for up to 30 days; don't place it back in the refrigerator once it's at room temperature. Don't use it after 30 days at room temperature.
Tips on how to take Bimzelx (bimekizumab):
Make sure you understand and are comfortable with how to inject Bimzelx (bimekizumab) before using the medication yourself. Your provider or pharmacist will show you how to inject the medication for your first time.
Take Bimzelx (bimekizumab) according to your provider's treatment plan. Confirm with your provider whether your injection is every month or every other month.
Remember that you'll typically have to use two prefilled autoinjectors or syringes at different injection sites for each dose. The total dose you need each time is 320 mg of Bimzelx (bimekizumab), and each autoinjector or syringe contains 160 mg of medication.
When it's time for your dose, take Bimzelx (bimekizumab) out of the refrigerator and let it come to room temperature before you inject the medication; this should take about 30 to 45 minutes. Then, wash your hands with soap and water and clean the area where you'll be injecting with an alcohol swab.
Inject Bimzelx (bimekizumab) under the skin of the belly, thighs, or back of the upper arm (with someone's help). Choose a different area to inject each time to prevent skin irritation.
For the Bimzelx (bimekizumab) prefilled syringes: Carefully pull the needle cap off the syringe. Gently pinch and hold a section of skin, and insert the needle under the skin at a 45-degree angle. Slowly push the plunger down until there's no more medication in the syringe and until you feel some resistance. Then, let go of the plunger; the needle will retract into the needle shield by itself.
For the Bimzelx (bimekizumab) prefilled autoinjectors: Pull off the cap, place the needle cover of the pen straight against your skin (at a 90-degree angle), and press down. When the injection starts, you'll hear a click and the window on the pen will start to turn yellow. When the injection is complete, the window will turn completely yellow and you'll hear another click. A complete injection takes about 15 seconds.
Throw away all used autoinjectors or syringes (along with the needle cap) in a sharps container. Visit the FDA page for more information about disposing your sharps to prevent needle-stick injuries.
Bimzelx (bimekizumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: History of depression | History of suicidal thoughts or behavior | Taking other medications that affect mood
During clinical studies, some people who took Bimzelx (bimekizumab) had suicidal thoughts or behavior. Tell your provider if you've had severe depression or suicidal thoughts before; your provider will discuss whether this medication is safe for you. Watch for worsening depression, any unusual changes in mood or behavior, or suicidal thoughts or behavior. Report anything concerning to your provider right away.
Risk factors: Active, chronic (long-term), or recurrent infection | History of active or latent tuberculosis (TB)
Bimzelx (bimekizumab) can lower the body's ability to fight infections, which can put you at risk for infections, including tuberculosis (TB). In studies, people reported sinus infections, fungal infections, stomach infections, and herpes during treatment. Serious infections rarely happened.
Before you start Bimzelx (bimekizumab), talk with your providers about your medical history so they can discuss how you can safely use this medication. Don't start Bimzelx (bimekizumab) if you currently have an infection or any infections that keep coming back. Your provider will also examine you for an active TB infection before you start the medication. You might need to take antibiotics to treat latent TB before you start Bimzelx (bimekizumab) to lower the risk that TB comes back during treatment.
Tell your provider right away if you have any signs or symptoms of an infection, such as fever, chills, cough, sore throat, weakness, or night sweats, while you're taking Bimzelx (bimekizumab).
Risk factor: History of liver problems
Rarely, people who use Bimzelx (bimekizumab) can have abnormal liver lab results from blood tests, which can sometimes suggest liver injury. These abnormal test results can appear between 1 to 6 months after you start this medication. Because of the risk for liver injury, it's recommended to avoid taking Bimzelx (bimekizumab) if you have liver problems, such as cirrhosis.
Make sure to get blood tests done as instructed by your provider while you use Bimzelx (bimekizumab) to check your liver health. Tell your provider right away if you have signs and symptoms of liver damage, such as upper right stomach pain, yellowing of the skin or whites of the eyes, or dark urine. Your provider might ask you to stop using Bimzelx (bimekizumab) to prevent further damage to your liver.
Some people who took Bimzelx (bimekizumab) have had symptoms of inflammatory bowel disease (IBD). Before starting treatment, let your provider know if you have a history of IBD. Talk to your provider if you have symptoms such as stomach pain, bloody stools, frequent changes in bowel movement (e.g., diarrhea, constipation), or sudden weight loss while you're taking Bimzelx (bimekizumab). Your provider will examine you for IBD.
Risk factor: Receiving live vaccines
Before you start Bimzelx (bimekizumab), talk with a provider or pharmacist about your or your child's vaccine history. Your provider can make sure all your vaccinations are up to date.
While we don’t completely know the effect Bimzelx (bimekizumab) has on vaccines, it’s possible that it can interact with any vaccine you get. Medications that affect the immune system might make vaccines not work as well. These medications might also raise the risk of infection from live vaccines themselves. For this reason, it's best to avoid getting any live vaccines, such as MMR (measles, mumps, and rubella vaccine), while you're taking Bimzelx (bimekizumab).
The typical starting dose is two 160 mg injections under the skin every month for the first 5 doses.
After that, the typical maintenance dose is two 160 mg injections under the skin every other month. If you weigh 264 pounds or more, your provider might consider a maintenance dose of two 160 mg injections every month.
Moderate-to-severe plaque psoriasis in adults
Moderate-to-severe plaque psoriasis in people ages 6 years and older
Psoriatic arthritis (PsA) in adults
Ankylosing spondylitis (AS) in adults
Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
Plaque psoriasis (PsO) in people ages 6 years and older
Psoriatic arthritis (PsA) in people ages 2 years and older who weigh at least 33 lbs
Ankylosing spondylitis (AS) in adults
Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
Enthesitis-related arthritis in people ages 4 years and older who weigh at least 33 lbs
Hidradenitis suppurativa in adults
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Abrouk, M., et al. (2017). The impact of PASI 75 and PASI 90 on quality of life in moderate to severe psoriasis patients. The Journal of Dermatological Treatment.
Centers for Disease Control and Prevention. (2014). The difference between latent TB infection and TB disease.
Kuwabara, T., et al. (2017). The role of IL-17 and related cytokines in inflammatory autoimmune diseases. Mediators of Inflammation.
MotherToBaby. (n.d.). MotherToBaby pregnancy studies.
U.S. Food and Drug Administration. (2021). Safely using sharps (needles and syringes) at home, at work and on travel.
UCB, Inc. (n.d.). Getting started with Bimzelx®.
UCB, Inc. (2023). Bimzelx[®] approved by the U.S. FDA for the treatment of adults with moderate to severe plaque psoriasis.
UCB, Inc. (2023). Bimzelx- bimekizumab injection, solution [package insert]. DailyMed.
UCB, Inc. (2023). Instructions for use: Bimzelx® (bim zel’ ex) (bimekizumab-bkzx) injection, for subcutaneous use - single-dose autoinjector.
UCB, Inc. (2023). Instructions for use: Bimzelx® (bim zel’ ex) (bimekizumab-bkzx) injection, for subcutaneous use - single-dose prefilled syringe.
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