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Bimzelx

bimekizumab
Used for Plaque Psoriasis
Used for Plaque Psoriasis

Bimzelx (bimekizumab or bimekizumab bkzx) is an injectable medication that's used to treat plaque psoriasis in adults. It's a monoclonal antibody that belongs to a class called interleukin antagonists. This medication is available as prefilled autoinjectors and prefilled syringes. It's injected under the skin of the belly, thighs, or the back of the upper arm. Bimzelx (bimekizumab) is typically injected every month at the beginning, and then every other month as you continue taking the medication. Common side effects include runny nose, cough, and oral thrush.

Last reviewed on December 7, 2023
basics-icon

What is Bimzelx (bimekizumab)?

What is Bimzelx (bimekizumab) used for?

How Bimzelx (bimekizumab) works

Bimzelx (bimekizumab) is a monoclonal antibody known as an interleukin receptor antagonist. It blocks interleukin-17A and interleukin-17F (IL-17A, IL-17F), which are proteins that are part of your immune system and are responsible for inflammation (redness and swelling).

By blocking these proteins, Bimzelx (bimekizumab) calms down the immune system. As a result, it can help ease symptoms of itchy skin and skin redness due to plaque psoriasis.

Drug Facts

Common BrandsBimzelx
Drug ClassInterleukin antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Bimzelx (bimekizumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Stomach flu (nausea, vomiting, stomach cramps)
  • Cold sores
  • Acne
  • Inflammation of hair follicles
  • Feeling tired

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Tuberculosis (TB): coughing up blood or mucus, weight loss, feeling tired or weak, fever, chills, night sweats
  • Other serious infections: fever, cough, chills, sore throat, runny or stuffy nose, body aches
  • Liver problems: nausea, vomiting, not feeling hungry, pain in the right side of the stomach, yellowing of the whites of the eyes or skin, dark-colored urine, light-colored stool

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Severe or prolonged diarrhea
  • Severe stomach pain
  • Thoughts of suicide or self-harm, worsening mood, feelings of depression

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Cold sores
  • Fatigue
  • Headache
  • Pain, redness, or irritation at injection site
  • Small, red, pus-filled bumps on skin around hair follicles
  • Thrush—white patches in the mouth
pros-and-cons

Pros and cons of Bimzelx (bimekizumab)

thumbs-up

Pros

Dosing is every month or every other month, so it's convenient for most people

Good option for psoriasis if topical medications have stopped working

Available as prefilled autoinjectors and prefilled syringes

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Cons

Can cause injection reactions, such as pain, bruising, and swelling

Might raise the risk of infections

Unknown if safe or works well during pregnancy or while breastfeeding

pharmacist-tips

Pharmacist tips for Bimzelx (bimekizumab)

pharmacist
  • Consider getting all your scheduled vaccines before you start treatment with Bimzelx (bimekizumab). It's not known how this medication affects how well vaccines work or how safe they are for you. But it's best to avoid live vaccines while you're taking Bimzelx (bimekizumab). Talk with your provider or pharmacist if you're due for a vaccine or if you're not sure which vaccines are safe for you.

    • Let your provider or pharmacist know what medications you're taking, including over-the-counter products and supplements. Bimzelx (bimekizumab) can interact with some medications, so your providers can check that your medications are safe to take together. Ask your provider or pharmacist if you have any questions about interactions with Bimzelx (bimekizumab).

      • Store Bimzelx (bimekizumab) in the refrigerator in its original container and away from light; throw it away once it's past the written expiration date on the carton.

        • You can also keep Bimzelx (bimekizumab) at room temperature (up to 77°F) for up to 30 days; don't place it back in the refrigerator once it's at room temperature. Don't use it after 30 days at room temperature.

          Tips on how to take Bimzelx (bimekizumab):

          • Make sure you understand and are comfortable with how to inject Bimzelx (bimekizumab) before using the medication yourself. Your provider or pharmacist will show you how to inject the medication for your first time.

            • Take Bimzelx (bimekizumab) according to your provider's treatment plan. Confirm with your provider whether your injection is every month or every other month.

              • Remember that you'll typically have to use two prefilled autoinjectors or syringes at different injection sites for each dose. The total dose you need each time is 320 mg of Bimzelx (bimekizumab), and each autoinjector or syringe contains 160 mg of medication.

                • When it's time for your dose, take Bimzelx (bimekizumab) out of the refrigerator and let it come to room temperature before you inject the medication; this should take about 30 to 45 minutes. Then, wash your hands with soap and water and clean the area where you'll be injecting with an alcohol swab.

                  • Inject Bimzelx (bimekizumab) under the skin of the belly, thighs, or back of the upper arm (with someone's help). Choose a different area to inject each time to prevent skin irritation.

                    • For the Bimzelx (bimekizumab) prefilled syringes: Carefully pull the needle cap off the syringe. Gently pinch and hold a section of skin, and insert the needle under the skin at a 45-degree angle. Slowly push the plunger down until there's no more medication in the syringe and until you feel some resistance. Then, let go of the plunger; the needle will retract into the needle shield by itself.

                      • For the Bimzelx (bimekizumab) prefilled autoinjectors: Pull off the cap, place the needle cover of the pen straight against your skin (at a 90-degree angle), and press down. When the injection starts, you'll hear a click and the window on the pen will start to turn yellow. When the injection is complete, the window will turn completely yellow and you'll hear another click. A complete injection takes about 15 seconds.

                        • Throw away all used autoinjectors or syringes (along with the needle cap) in a sharps container. Visit the FDA page for more information about disposing your sharps to prevent needle-stick injuries.

                          faqs

                          Frequently asked questions about Bimzelx (bimekizumab)

                          How long does Bimzelx (bimekizumab) take to work?
                          Studies show that more than 70% of people who used Bimzelx (bimekizumab) had noticeable improvements in their plaque psoriasis in as early as a month after starting treatment. In addition, more than 80% of people had completely clear or almost clear skin after taking the medication for about 3 months. Talk with your provider if you've been using Bimzelx (bimekizumab) for a while and haven't had any improvement in your condition.
                          Where is Bimzelx (bimekizumab) administered?
                          Inject Bimzelx (bimekizumab) under the skin on the thighs or belly (at least 2 inches away from the belly button). If you're helping someone inject the medication, Bimzelx (bimekizumab) can also be injected under the skin on the underside of the upper arms. Since you need two injections for your dose, make sure to choose different areas for each injection. In general, you want to change which site you inject into often to prevent skin irritation and to let the medication absorb into the body well. Don't inject into skin that's bruised, red, tender, or hard. Ask your provider or pharmacist if you have any questions about where to inject Bimzelx (bimekizumab).
                          Is Bimzelx (bimekizumab) a steroid?
                          No, Bimzelx (bimekizumab) isn't a steroid. Instead, it's a monoclonal antibody that acts as an interleukin antagonist. Similar to steroids, Bimzelx (bimekizumab) blocks certain (but different) proteins that cause inflammation in the body to help relieve plaque psoriasis. Your provider might prescribe Bimzelx (bimekizumab) along with steroid medications to treat your condition and to control your symptoms better.
                          Is Bimzelx (bimekizumab) a biologic?
                          Yes, Bimzelx (bimekizumab) is considered a biologic medication, meaning it's made from living sources. Specifically, it's a type of monoclonal antibody that's made in a lab to target and block certain proteins called interleukins from causing inflammation in the body.
                          Will Bimzelx (bimekizumab) affect how well my blood thinner works?
                          Using Bimzelx (bimekizumab) to treat plaque psoriasis might affect how your body gets rid of the blood thinner called warfarin (Coumadin). This can either raise your risk of bleeding or clotting. Let your providers know if you're taking these two medications. Your providers will probably want to follow up with you more often to check that your blood thinner is safe for you and adjust its dose, if needed. Make sure to go to your appointments for your routine blood checks for warfarin (Coumadin).
                          Is it safe to take Bimzelx (bimekizumab) while pregnant?
                          It's not clear whether Bimzelx (bimekizumab) is safe during pregnancy. This is because there aren't enough studies researching this to know for sure. Tell your provider right away if you become pregnant while you're taking Bimzelx (bimekizumab). You’re encouraged to enroll in a pregnancy exposure registry that monitors and collects information about your and your baby’s health. Learn more about this pregnancy exposure registry by calling 1-877-311-8972.
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                          warings-icon

                          What are the risks and warnings for Bimzelx (bimekizumab)?

                          Bimzelx (bimekizumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                          risk-warning

                          Suicidal thoughts or behavior

                          • Risk factors: History of depression | History of suicidal thoughts or behavior | Taking other medications that affect mood

                            During clinical studies, some people who took Bimzelx (bimekizumab) had suicidal thoughts or behavior. Tell your provider if you've had severe depression or suicidal thoughts before; your provider will discuss whether this medication is safe for you. Watch for worsening depression, any unusual changes in mood or behavior, or suicidal thoughts or behavior. Report anything concerning to your provider right away.

                            risk-warning

                            Infections

                            • Risk factors: Active, chronic (long-term), or recurrent infection | History of active or latent tuberculosis (TB)

                              Bimzelx (bimekizumab) can lower the body's ability to fight infections, which can put you at risk for infections, including tuberculosis (TB). In studies, people reported sinus infections, fungal infections, stomach infections, and herpes during treatment. Serious infections rarely happened.

                              Before you start Bimzelx (bimekizumab), talk with your providers about your medical history so they can discuss how you can safely use this medication. Don't start Bimzelx (bimekizumab) if you currently have an infection or any infections that keep coming back. Your provider will also examine you for an active TB infection before you start the medication. You might need to take antibiotics to treat latent TB before you start Bimzelx (bimekizumab) to lower the risk that TB comes back during treatment.

                              Tell your provider right away if you have any signs or symptoms of an infection, such as fever, chills, cough, sore throat, weakness, or night sweats, while you're taking Bimzelx (bimekizumab).

                              risk-warning

                              Liver problems

                              • Risk factor: History of liver problems

                                Rarely, people who use Bimzelx (bimekizumab) can have abnormal liver lab results from blood tests, which can sometimes suggest liver injury. These abnormal test results can appear between 1 to 6 months after you start this medication. Because of the risk for liver injury, it's recommended to avoid taking Bimzelx (bimekizumab) if you have liver problems, such as cirrhosis.

                                Make sure to get blood tests done as instructed by your provider while you use Bimzelx (bimekizumab) to check your liver health. Tell your provider right away if you have signs and symptoms of liver damage, such as upper right stomach pain, yellowing of the skin or whites of the eyes, or dark urine. Your provider might ask you to stop using Bimzelx (bimekizumab) to prevent further damage to your liver.

                                risk-warning

                                Inflammatory bowel disease

                                Some people who took Bimzelx (bimekizumab) have had symptoms of inflammatory bowel disease (IBD). Before starting treatment, let your provider know if you have a history of IBD. Talk to your provider if you have symptoms such as stomach pain, bloody stools, frequent changes in bowel movement (e.g., diarrhea, constipation), or sudden weight loss while you're taking Bimzelx (bimekizumab). Your provider will examine you for IBD.

                                risk-warning

                                Interaction with vaccines

                                • Risk factor: Receiving live vaccines

                                  Before you start Bimzelx (bimekizumab), talk with a provider or pharmacist about your or your child's vaccine history. Your provider can make sure all your vaccinations are up to date.

                                  While we don’t completely know the effect Bimzelx (bimekizumab) has on vaccines, it’s possible that it can interact with any vaccine you get. Medications that affect the immune system might make vaccines not work as well. These medications might also raise the risk of infection from live vaccines themselves. For this reason, it's best to avoid getting any live vaccines, such as MMR (measles, mumps, and rubella vaccine), while you're taking Bimzelx (bimekizumab).

                                  dosage

                                  Bimzelx (bimekizumab) dosage forms

                                  Typical dosing for Bimzelx (bimekizumab)

                                  The typical starting dose is two 160 mg injections under the skin every month for the first 5 doses.

                                  After that, the typical maintenance dose is two 160 mg injections under the skin every other month. If you weigh 264 pounds or more, your provider might consider a maintenance dose of two 160 mg injections every month.

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                                  How much does Bimzelx (bimekizumab) cost?

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                                  alternatives

                                  What are alternatives to Bimzelx (bimekizumab)?

                                  There are a number of medications that your doctor can prescribe in place of Bimzelx (bimekizumab). Compare a few possible alternatives below.
                                  Bimzelx (bimekizumab)
                                  Used for:
                                  $15218.19 Lowest GoodRx priceView Prices
                                  Used for:
                                  • Moderate-to-severe plaque psoriasis in people ages 6 years and older

                                  • Psoriatic arthritis (PsA) in adults

                                  • Ankylosing spondylitis (AS) in adults

                                  • Non-radiographic axial spondyloarthritis (nr-axSpA) in adults

                                  Used for:
                                  $7180.92 Lowest GoodRx priceView Prices

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                                  References

                                  Best studies we found

                                  Abrouk, M., et al. (2017). The impact of PASI 75 and PASI 90 on quality of life in moderate to severe psoriasis patients. The Journal of Dermatological Treatment.

                                  Centers for Disease Control and Prevention. (2014). The difference between latent TB infection and TB disease.

                                  Kuwabara, T., et al. (2017). The role of IL-17 and related cytokines in inflammatory autoimmune diseases. Mediators of Inflammation.

                                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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