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Compare Tremfya vs. Humira

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tremfya (guselkumab) and Humira (adalimumab) are both injectable medications used to treat autoimmune conditions, but they have some key differences. Tremfya is a monoclonal antibody that targets interleukin-23 (IL-23) to reduce inflammation and is specifically approved for moderate-to-severe plaque psoriasis and active psoriatic arthritis. On the other hand, Humira is a biologic disease-modifying antirheumatic drug (DMARD) that blocks tumor necrosis factor (TNF) and is approved for a wider range of conditions, including rheumatoid arthritis, Crohn's disease, and ulcerative colitis, among others. Tremfya is typically injected every 8 weeks after initial doses, while Humira is usually injected every other week. Tremfya is only available as a brand-name medication, making it potentially more expensive, whereas Humira has several biosimilars available. Both medications can increase the risk of infections, but Humira also carries warnings for potential risks of certain cancers and heart failure.

  • Tremfya (guselkumab)
    Humira (adalimumab)
  • Tremfya (guselkumab)
    Humira (adalimumab)

  • Summary of Tremfya vs. Humira

    Summary for Interleukin antagonist
    Prescription only

    Tremfya (guselkumab) is an injection for adults with certain inflammatory conditions. It helps treat plaque psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn's disease. Tremfya (guselkumab) is a monoclonal antibody known as an interleukin antagonist. It calms your immune system to lower inflammation. The dosing schedule is every 1 or 2 months, depending on your condition and how far along you are in treatment. Side effects are upper respiratory infections, headache, and injection site reactions. There's also a risk of other infections and liver problems as long-term side effects.

    Summary for Biologic DMARD
    Prescription only

    Humira (adalimumab) is an injectable medication used for treating many different autoimmune conditions, including rheumatoid arthritis (RA), Crohn's disease (CD), ulcerative colitis (UC), and plaque psoriasis. It's usually given every other week, and it can be used alone or taken with methotrexate or other non-biologic medications. This medication is available as many different brands (or biosimilars).

  • Indications of Tremfya vs. Humira

    Indications for
    •Moderate-to-severe plaque psoriasis
    •Active psoriatic arthritis
    •Moderate-to-severe ulcerative colitis (UC)
    •Moderate-to-severe Crohn's disease (CD)
    Indications for
    •Rheumatoid arthritis (RA) - adults only
    •Juvenile idiopathic arthritis (JIA) - people age 2 and older
    •Psoriatic arthritis (PsA) - adults only
    •Ankylosing spondylitis (AS) - adults only
    •Crohn's disease (CD) - people age 6 and older
    •Ulcerative colitis (UC) - people age 5 and older
    •Plaque psoriasis - adults only
    •Hidradenitis suppurativa (HS) - people age 12 and older
    •Uveitis - people age 2 and older

  • Pros and Cons of Tremfya vs. Humira

    Pros and Const for Interleukin antagonist
    Pros
    •An option for adults with plaque psoriasis who've already tried topical treatment
    •Given every 1 or 2 months (depending on your condition and treatment plan)
    •Few side effects
    •Can give yourself injections under the skin at home after you get trained
    Cons
    •Given as an injection under the skin or injection through the vein
    •Raises the risk of infections
    •Can cause some injection site reactions
    •Can take several months to see the benefits of the medication
    Pros and Const for Biologic DMARD
    Pros
    •Can be used for many autoimmune conditions
    •Available as a ready-to-use pen that makes it easier to self-inject at home
    •Can be used in young children (as young as 2 years old for some conditions)
    •Only needs to be injected a couple times a month
    •Can be left at room temperature for up to 14 days if needed
    Cons
    •Raises the risk of serious infections
    •Might raise the risk of lymphoma and skin cancers
    •Might be difficult to inject for some people
    •Can't receive any live vaccines while taking the medication
    •Contains rubber or latex, which can cause a reaction for those with an allergy

  • Common Side Effects of Tremfya vs. Humira

    Common Side Effects for
    •Upper respiratory infections (14%)
    •Headache (5%)
    •Injection site reactions (5%)
    •Joint pain (3%)
    Common Side Effects for
    •Injection-site reaction (20%)
    •Upper respiratory tract infection (17%)
    •Headache (12%)
    •Rash (12%)
    •Sinus inflammation (11%)
    •Accidental injury (10%)
    •Nausea (9%)
    •Urinary tract infection (UTI) or bladder infection (8%)

  • Warnings of Tremfya vs. Humira

    Common Side Effects for
    •Serious allergic reactions
    •Risk of infections
    •Liver damage
    •Interaction with vaccines
    Common Side Effects for
    •Serious infections
    •Cancers
    •Severe allergic reactions
    •Nervous system effects
    •Low blood cell counts
    •Heart failure
    •Live vaccines

  • Prices with our coupons for Tremfya vs. Humira

    Learn more about Tremfya
    Learn more about Humira

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