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Compare Tremfya vs. Taltz

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tremfya (guselkumab) and Taltz (ixekizumab) are both monoclonal antibody medications used to treat moderate-to-severe plaque psoriasis and psoriatic arthritis. However, they belong to different classes of interleukin antagonists. Tremfya targets interleukin-23 (IL-23), while Taltz targets interleukin-17 (IL-17). Tremfya is also used for ulcerative colitis and Crohn's disease, while Taltz is approved for additional conditions like ankylosing spondylitis and non-radiographic axial spondyloarthritis. Tremfya is typically injected every 8 weeks after initial doses, whereas Taltz is injected every 4 weeks after the starting doses. Both medications are only available as brand-name options. Common side effects for both include upper respiratory infections and injection site reactions. Both medications can increase the risk of infections due to their effects on the immune system, and you should avoid live vaccines while using them.

  • Tremfya (guselkumab)
    Taltz (ixekizumab)
  • Tremfya (guselkumab)
    Taltz (ixekizumab)

  • Summary of Tremfya vs. Taltz

    Summary for Interleukin antagonist
    Prescription only

    Tremfya (guselkumab) is an injection for adults with certain inflammatory conditions. It helps treat plaque psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn's disease. Tremfya (guselkumab) is a monoclonal antibody known as an interleukin antagonist. It calms your immune system to lower inflammation. The dosing schedule is every 1 or 2 months, depending on your condition and how far along you are in treatment. Side effects are upper respiratory infections, headache, and injection site reactions. There's also a risk of other infections and liver problems as long-term side effects.

    Summary for Interleukin antagonist
    Prescription only

    Taltz (ixekizumab) is an injection that's given under the skin. It helps treat inflammatory conditions, including plaque psoriasis, psoriatic arthritis, and some types of arthritis in the spine. This medication works as an interleukin antagonist to lessen inflammation in the body. You inject Taltz (ixekizumab) once a month using the prefilled syringe or autoinjector. The dose depends on the health problem you're treating. Side effects include upper respiratory infections. You also might feel pain or have redness around the injection area. Taltz (ixekizumab) is a brand-name medication.

  • Indications of Tremfya vs. Taltz

    Indications for
    •Moderate-to-severe plaque psoriasis
    •Active psoriatic arthritis
    •Moderate-to-severe ulcerative colitis (UC)
    •Moderate-to-severe Crohn's disease (CD)
    Indications for
    •Moderate-to-severe plaque psoriasis in people 6 years and older
    •Psoriatic arthritis in adults
    •Ankylosing spondylitis in adults
    •Non-radiographic axial spondyloarthritis in adults

  • Pros and Cons of Tremfya vs. Taltz

    Pros and Const for Interleukin antagonist
    Pros
    •An option for adults with plaque psoriasis who've already tried topical treatment
    •Given every 1 or 2 months (depending on your condition and treatment plan)
    •Few side effects
    •Can give yourself injections under the skin at home after you get trained
    Cons
    •Given as an injection under the skin or injection through the vein
    •Raises the risk of infections
    •Can cause some injection site reactions
    •Can take several months to see the benefits of the medication
    Pros and Const for Interleukin antagonist
    Pros
    •Generally given once a month (might need some starter doses)
    •Available as a prefilled syringe or autoinjector for easier use
    •Can inject at home after a healthcare professional trains you (for most people)
    Cons
    •Only given as an injection under the skin
    •Raises the risk of infections
    •Might cause flare-ups in people with Crohn's disease or ulcerative colitis

  • Common Side Effects of Tremfya vs. Taltz

    Common Side Effects for
    •Upper respiratory infections (14%)
    •Headache (5%)
    •Injection site reactions (5%)
    •Joint pain (3%)
    Common Side Effects for
    •Reaction at the injection site (e.g., redness, pain; 17%)
    •Upper respiratory tract infections (14%)

  • Warnings of Tremfya vs. Taltz

    Common Side Effects for
    •Serious allergic reactions
    •Risk of infections
    •Liver damage
    •Interaction with vaccines
    Common Side Effects for
    •Risk of infection
    •Caution when getting vaccines
    •Eczema-like skin reaction
    •Allergic reaction
    •Inflammatory bowel disease

  • Prices with our coupons for Tremfya vs. Taltz

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