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Compare Skyrizi vs. Cosentyx

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Skyrizi (risankizumab) and Cosentyx (secukinumab) are both injectable medications used to treat inflammatory conditions, but they have some key differences. Skyrizi is an interleukin-23 (IL-23) antagonist, while Cosentyx is an interleukin-17 (IL-17) inhibitor. Skyrizi is typically administered every 2 to 3 months after initial doses, whereas Cosentyx is usually given monthly after a series of weekly starter doses. Skyrizi is used for plaque psoriasis, psoriatic arthritis, and Crohn's disease, while Cosentyx treats plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, enthesitis-related arthritis, and hidradenitis suppurativa. Skyrizi is not approved for use in children, but Cosentyx can be used in children for certain conditions. Common side effects of Skyrizi include joint pain and upper respiratory infections, while Cosentyx may cause the common cold and diarrhea. Both medications can increase the risk of infections and should be used with caution if you have a history of infections.

  • Skyrizi (risankizumab)
    Cosentyx (secukinumab)
  • Skyrizi (risankizumab)
    Cosentyx (secukinumab)

  • Summary of Skyrizi vs. Cosentyx

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

    Summary for Interleukin 17 (IL-17) inhibitor
    Prescription only

    Cosentyx (secukinumab) is a monoclonal antibody known as an interleukin 17 (IL-17) inhibitor. It's used to treat several inflammatory conditions, including plaque psoriasis, ankylosing spondylitis, and hidradenitis suppurativa. Cosentyx (secukinumab) comes as a pre-filled pen and syringe, and is typically injected under the skin monthly. It can also be given as an infusion through the veins by a healthcare provider for certain conditions, usually in a clinic setting. Side effects aren't common, but can include the common cold and diarrhea.

  • Indications of Skyrizi vs. Cosentyx

    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults
    Indications for
    •Plaque psoriasis (PsO) in people ages 6 years and older
    •Psoriatic arthritis (PsA) in people ages 2 years and older who weigh at least 33 lbs
    •Ankylosing spondylitis (AS) in adults
    •Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
    •Enthesitis-related arthritis in people ages 4 years and older who weigh at least 33 lbs
    •Hidradenitis suppurativa in adults

  • Pros and Cons of Skyrizi vs. Cosentyx

    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children
    Pros and Const for Interleukin 17 (IL-17) inhibitor
    Pros
    •Works well to treat several different inflammatory problems
    •Injected monthly (after the loading doses)
    •Available as a prefilled syringe or Sensoready pen for easy at-home injections
    •Can be used in children (for plaque psoriasis, psoriatic arthritis, and enthesitis-related arthritis)
    Cons
    •Only available as injections
    •Raises the risk of infections
    •Can worsen inflammatory bowel disease (IBD) (e.g., ulcerative colitis or Crohn's disease) symptoms
    •Pens and prefilled syringes not appropriate for those with latex allergy

  • Common Side Effects of Skyrizi vs. Cosentyx

    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)
    Common Side Effects for
    •Common cold (12%)
    •Diarrhea (4%)
    •Upper respiratory infections (3%)

    Note: Side effects listed were reported by adults who took Cosentyx (secukinumab) for PsO in clinical trials.

  • Warnings of Skyrizi vs. Cosentyx

    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines
    Common Side Effects for
    •Infections
    •Caution when getting vaccines
    •Allergic and skin reactions
    •Worsening of inflammatory bowel disease

  • Prices with our coupons for Skyrizi vs. Cosentyx

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