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Compare Tremfya vs. Skyrizi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tremfya (guselkumab) and Skyrizi (risankizumab) are both medications used to treat moderate-to-severe plaque psoriasis, psoriatic arthritis, and Crohn's disease, as well as ulcerative colitis. They belong to the same class of monoclonal antibodies and work by blocking interleukin-23 (IL-23) to reduce inflammation. However, they differ in several ways. Tremfya is administered as a 100 mg subcutaneous (under the skin) injection every 8 weeks after initial doses, whereas Skyrizi's dosing varies: for psoriasis and arthritis, it's 150 mg every 3 months after initial doses, and for Crohn's disease and ulcerative colitis, it starts with intravenous (IV) infusions followed by subcutaneous injections. Both are only available as brand-name medications. Common side effects for both include upper respiratory infections and joint pain, but Skyrizi may also cause tiredness and has a rare risk of liver injury. Both medications increase the risk of infections and require caution with live vaccines.

  • Tremfya (guselkumab)
    Skyrizi (risankizumab)
  • Tremfya (guselkumab)
    Skyrizi (risankizumab)

  • Summary of Tremfya vs. Skyrizi

    Summary for Interleukin antagonist
    Prescription only

    Tremfya (guselkumab) is an injection for adults with certain inflammatory conditions. It helps treat plaque psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn's disease. Tremfya (guselkumab) is a monoclonal antibody known as an interleukin antagonist. It calms your immune system to lower inflammation. The dosing schedule is every 1 or 2 months, depending on your condition and how far along you are in treatment. Side effects are upper respiratory infections, headache, and injection site reactions. There's also a risk of other infections and liver problems as long-term side effects.

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

  • Indications of Tremfya vs. Skyrizi

    Indications for
    •Moderate-to-severe plaque psoriasis
    •Active psoriatic arthritis
    •Moderate-to-severe ulcerative colitis (UC)
    •Moderate-to-severe Crohn's disease (CD)
    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults

  • Pros and Cons of Tremfya vs. Skyrizi

    Pros and Const for Interleukin antagonist
    Pros
    •An option for adults with plaque psoriasis who've already tried topical treatment
    •Given every 1 or 2 months (depending on your condition and treatment plan)
    •Few side effects
    •Can give yourself injections under the skin at home after you get trained
    Cons
    •Given as an injection under the skin or injection through the vein
    •Raises the risk of infections
    •Can cause some injection site reactions
    •Can take several months to see the benefits of the medication
    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children

  • Common Side Effects of Tremfya vs. Skyrizi

    Common Side Effects for
    •Upper respiratory infections (14%)
    •Headache (5%)
    •Injection site reactions (5%)
    •Joint pain (3%)
    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)

  • Warnings of Tremfya vs. Skyrizi

    Common Side Effects for
    •Serious allergic reactions
    •Risk of infections
    •Liver damage
    •Interaction with vaccines
    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines

  • Prices with our coupons for Tremfya vs. Skyrizi

    Learn more about Tremfya
    Learn more about Skyrizi

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