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Compare Nucala vs. Dupixent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Nucala (mepolizumab)
    Dupixent (dupilumab)
  • Nucala (mepolizumab)
    Dupixent (dupilumab)

  • Summary of Nucala vs. Dupixent

    Summary for Interleukin antagonist
    Prescription only

    Nucala (mepolizumab) is an injection that treats certain inflammatory problems. This includes severe asthma in people 6 years and older. It can also treat chronic obstructive pulmonary disease (COPD) and sinus congestion with nasal polyps in adults. The medication works as an interleukin antagonist to lower inflammation. It's injected under the skin once a month. You can inject it on your own with the prefilled autoinjector or syringe. A healthcare professional can also give the injection at a medical office. Side effects include headache and injection site reactions.

    Summary for Interleukin antagonist
    Prescription only

    Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

  • Indications of Nucala vs. Dupixent

    Indications for
    •Severe asthma - add-on maintenance for people ages 6 years and older
    •Chronic obstructive pulmonary disease (COPD) - add-on maintenance for adults
    •Chronic rhinosinusitis with nasal polyps - add-on maintenance for adults
    •Eosinophilic granulomatosis with polyangiitis (EGPA) - for adults
    •Hypereosinophilic syndrome (HES) - for people ages 12 years and older
    Indications for
    •Moderate-to-severe eczema - for people 6 months and older
    •Moderate-to-severe asthma - add-on maintenance for people 6 years and older
    •Long-term sinus congestion with nasal polyps - add-on maintenance for people 12 years and older
    •Eosinophilic esophagitis - for people 1 year and older
    •Prurigo nodularis (long-term itchy skin bumps) - for adults
    •Chronic obstructive pulmonary disease (COPD) - add-on maintenance for adults
    •Long-term hives - for people 12 years and older

  • Pros and Cons of Nucala vs. Dupixent

    Pros and Const for Interleukin antagonist
    Pros
    •Only given once a month
    •Available as a prefilled autoinjector and syringe for injections at home
    Cons
    •Must give as an injection
    •Doses higher than 100 mg need more than one injection given one after another
    Pros and Const for Interleukin antagonist
    Pros
    •Taken every other week or monthly for most conditions
    •Approved for some children (specific age depends on the condition)
    •Available as prefilled pens (for people ages 2 years and older)
    •Available as prefilled syringes (for people ages 6 months and older)
    Cons
    •Given as an injection under the skin
    •Not used for helping with asthma attacks
    •Can cause injection reactions, such as pain, bruising, and swelling
    •Unknown if it's safe or works well while pregnant or breastfeeding

  • Common Side Effects of Nucala vs. Dupixent

    Common Side Effects for
    •Headache (19%)
    •Injection site reactions (e.g., pain, redness, swelling, itching, burning; 8%)
    •Back pain (5%)
    •Fatigue (5%)
    Common Side Effects for
    •Injection site reaction (e.g., pain, swelling, bruising; 10%)
    •Eye redness or eye inflammation (10%)
    •Cold sores (4%)

  • Warnings of Nucala vs. Dupixent

    Common Side Effects for
    •Allergic reactions
    •Not for an asthma or COPD attack
    •Caution when using corticosteroids
    •Possible herpes zoster infection (shingles)
    •Unclear effect in people with parasitic worm infections
    Common Side Effects for
    •Allergic reactions
    •Eye inflammation
    •Other inflammation in the body
    •Risk of worsening of breathing problems in people with asthma or COPD
    •Risk of psoriasis
    •Joint pain and psoriatic arthritis
    •Unknown effect in people with parasitic worm infections
    •Interaction with vaccines

  • Prices with our coupons for Nucala vs. Dupixent

    Learn more about Nucala
    Learn more about Dupixent

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