Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Montelukast (Singulair) and Breo Ellipta (fluticasone/vilanterol) are both used to manage asthma, but they work in different ways and have different uses. Montelukast is a leukotriene receptor antagonist, which helps reduce inflammation and swelling by blocking leukotrienes. It is taken orally once daily, usually in the evening. Montelukast also helps manage seasonal and year-round allergies and can prevent exercise-induced asthma. Breo Ellipta, on the other hand, is an inhaled combination of a corticosteroid (fluticasone) and a long-acting beta agonist (vilanterol). It helps by reducing lung inflammation and relaxing lung muscles to open airways. Breo Ellipta is also used for chronic obstructive pulmonary disease (COPD) and is taken once daily through inhalation. Montelukast is available in various forms, including chewable tablets and granules, making it suitable for children. Breo Ellipta requires rinsing your mouth after use to prevent fungal infections, while montelukast does not have this requirement. Both medications are available as lower-cost generics.
Montelukast (Singular)
Breo ellipta (fluticasone furoate / vilanterol)
Montelukast (Singular)
Breo ellipta (fluticasone furoate / vilanterol)
Summary of Singular vs. Breo Ellipta
Summary for Leukotriene receptor antagonist
Prescription only
Montelukast, the generic for Singulair, is used to help control asthma over time and prevent breathing problems during exercise in both adults and children. It's also used to help relieve allergy symptoms. Montelukast (Singular) comes as tablets, chewable tablets, or oral granules and is usually taken by mouth once a day. Common side effects include upper respiratory infection and headache, and it has a boxed warning for serious mood and behavior changes.
Summary for Inhaled corticosteroid / LABA
Prescription only
Breo Ellipta (fluticasone furoate / vilanterol) is a maintenance inhaler used every day to help manage asthma and chronic obstructive pulmonary disease (COPD). It's a combination of two medications: fluticasone, a corticosteroid that reduces swelling in your lungs, and vilanterol, a long-acting beta agonist (LABA) that helps relax your airways. The typical dose is one puff by mouth once a day. Breo Ellipta (fluticasone furoate / vilanterol) isn't for sudden breathing problems or asthma attacks. Side effects include oral thrush, sore throat, and headache.
Indications of Singular vs. Breo Ellipta
Indications for
•Long-term treatment of asthma - age 12 months and older