Key takeaways
Montelukast (Singulair) and fluticasone (Flonase, Flonase Sensimist) are both used to treat allergy symptoms, but they work in different ways and have different uses. Montelukast is a leukotriene receptor antagonist taken orally. It helps manage asthma and prevent exercise-induced asthma, in addition to treating seasonal and year-round allergies. Montelukast is not suitable for sudden asthma attacks. It is available in generic form and comes in tablets, chewable tablets, and granules. On the other hand, fluticasone is a corticosteroid nasal spray that reduces inflammation in the nose to relieve symptoms like congestion, runny nose, and sneezing. Fluticasone is available both by prescription and over-the-counter, and it also comes in generic form. Both medications are taken once daily, but fluticasone should not be used for more than 6 months without consulting a healthcare provider. Montelukast can cause serious mental health side effects, whereas fluticasone can lead to nosebleeds, slower growth in children, and increased risk of eye problems and infections.
