Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Breztri vs. Advair

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Breztri Aerosphere (budesonide/glycopyrrolate/formoterol) and Advair (fluticasone/salmeterol) are both inhaled medications used for the maintenance treatment of chronic obstructive pulmonary disease (COPD). They both contain an inhaled corticosteroid (ICS) and a long-acting beta agonist (LABA), but Breztri also includes a long-acting muscarinic antagonist (LAMA), making it an ICS/LAMA/LABA combination, while Advair is an ICS/LABA combination. Breztri is specifically approved for COPD, whereas Advair is approved for both COPD and asthma, with Advair Diskus being the form used for COPD. Breztri is taken as two inhalations twice daily, while Advair Diskus is typically one inhalation twice daily for COPD. Breztri is only available as a brand-name medication, whereas Advair has a generic version called Wixela Inhub. Common side effects of Breztri include upper respiratory tract infections and pneumonia, while Advair can cause upper respiratory infections, sore throat, and headaches. Both medications can increase the risk of fungal infections in the mouth, so it's important to rinse your mouth after use. Additionally, Breztri should not be used with other LABA-containing inhalers.

  • Breztri
    Advair (fluticasone / salmeterol)
  • Breztri
    Advair (fluticasone / salmeterol)

  • Summary of Breztri vs. Advair

    Summary for ICS / LAMA / LABA
    Prescription only

    Breztri Aerosphere is a combination inhaler that contains budesonide (an inhaled corticosteroid), glycopyrrolate (a long-acting muscarinic antagonist), and formoterol (a long-acting beta agonist). It's used for maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. Breztri is inhaled through the mouth and into the lungs twice per day every day. The most common side effects are upper respiratory tract infections and pneumonia. Breztri is brand name only and not available as a lower-cost generic.

    Summary for ICS / LABA combo
    Prescription only

    Advair is a combination inhaler that contains fluticasone (an inhaled corticosteroid) and salmeterol (a long-acting beta agonist, or LABA). Advair Diskus is used for maintenance treatment of chronic obstructive pulmonary disease (COPD) and asthma in adults and children, where as Advair HFA is for asthma only. Advair (fluticasone / salmeterol) is inhaled through the mouth, typically 1 to 2 puffs twice daily. Some common side effects of this medication include upper respiratory tract infection, sore throat, and headache.

  • Indications of Breztri vs. Advair

    Indications for
    •Maintenance treatment of chronic obstructive pulmonary disease (COPD)
    Indications for
    •Maintenance treatment of asthma
    •Maintenance treatment of COPD - Advair Diskus 250/50 only

  • Pros and Cons of Breztri vs. Advair

    Pros and Const for ICS / LAMA / LABA
    Pros
    •Lowers the risk of COPD flare-ups
    •Combination of three medications in a single inhaler
    •Can be used with a spacer to make it easier to take a dose
    Cons
    •Need to rinse your mouth after each dose
    •Need to inhale 2 puffs twice daily
    •Doesn't treat sudden worsening symptoms of COPD
    Pros and Const for ICS / LABA combo
    Pros
    •Works well to lower the risk of asthma or COPD symptoms
    •Combines two medications into a single inhaler for convenience
    •Available as two different types of inhalers (Advair Diskus and Advair HFA)
    Cons
    •Can cause fungal infections (thrush) in your mouth and throat
    •Advair Diskus contains lactose, so it might not be safe for people with severe milk protein allergies
    •Doesn't replace your rescue inhaler

  • Common Side Effects of Breztri vs. Advair

    Common Side Effects for
    •Upper respiratory tract infection (6%)
    •Pneumonia (5%)
    Common Side Effects for

    Advair Diskus:

    •Upper respiratory infection (up to 27%)
    •Sore throat (up to 13%)
    •Headache (up to 13%)
    •Bronchitis (up to 8%)
    •Cough (up to 6%)
    •Nausea and vomiting (up to 6%)
    •Hoarseness (up to 5%)

    Advair HFA:

    •Upper respiratory infection (up to 24%)
    •Headache (up to 21%)
    •Throat irritation (up to 9%)
    •Muscle and bone pain (up to 7%)
    •Nausea and vomiting (up to 5%)

  • Warnings of Breztri vs. Advair

    Common Side Effects for
    •Not for asthma, COPD flare ups, or worsening breathing
    •Fungal infection in the mouth
    •Narrowing of your airways (bronchospasm)
    •Allergic reactions
    •Higher risk of infections
    •Changes in stress hormone levels
    •Eye and vision problems
    •Heart problems
    •Low potassium levels in the blood
    •Trouble urinating
    Common Side Effects for
    •Not for use in asthma attack or for worsening breathing
    •Fungal infection in the mouth
    •Narrowing of your airways (bronchospasm)
    •Higher risk of infections
    •Altered stress hormone levels
    •Delayed growth in children
    •Eye and vision problems
    •Heart problems
    •Low potassium levels in the blood
    •Allergic reactions

  • Prices with our coupons for Breztri vs. Advair

    Learn more about Breztri
    Learn more about Advair

Compare other COPD drugs

Breztri Aerosphere vs AdvairBreztri Aerosphere vs AlbuterolBreztri Aerosphere vs Anoro ElliptaBreztri Aerosphere vs SpirivaBreztri Aerosphere vs SymbicortBreztri Aerosphere vs Trelegy ElliptaAdvair vs AlbuterolAdvair vs PulmicortAdvair vs Trelegy ElliptaAirduo vs AdvairAnoro Ellipta vs SymbicortAnoro Ellipta vs Trelegy ElliptaAtrovent vs AdvairBreo Ellipta vs AdvairBreo Ellipta vs SymbicortBreo Ellipta vs Trelegy ElliptaCombivent vs SymbicortDulera vs AdvairDulera vs SymbicortDupixent vs SymbicortFlovent vs AdvairFlovent vs SymbicortIncruse Ellipta vs SymbicortIncruse Ellipta vs Trelegy ElliptaQvar vs AdvairQvar vs SymbicortSingulair vs SymbicortSpiriva vs SymbicortSymbicort vs AdvairSymbicort vs Albuterol
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.