Key takeaways
Breztri Aerosphere (budesonide/glycopyrrolate/formoterol) and Anoro Ellipta (umeclidinium/vilanterol) are both inhaled medications used for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. However, they differ in several ways. Breztri Aerosphere is a combination of three medications: an inhaled corticosteroid (ICS), a long-acting muscarinic antagonist (LAMA), and a long-acting beta agonist (LABA). In contrast, Anoro Ellipta combines only a LAMA and a LABA, and it does not contain a steroid. Breztri is taken as two inhalations twice daily, while Anoro Ellipta is taken as one inhalation once daily. Both medications are only available as brand-name medications. Common side effects of both medications include upper respiratory tract infections and pneumonia and should not be used for sudden breathing problems. You should have a rescue inhaler like albuterol on hand for such situations. Additionally, Breztri requires rinsing your mouth after use to prevent oral thrush, a step not needed with Anoro Ellipta.
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