HomeHealth TopicRespiratory

Albuterol vs. Levalbuterol Rescue Inhalers: What’s the Difference?

Timothy Aungst, PharmDAlyssa Billingsley, PharmD
Updated on February 13, 2023

Key takeaways:

  • Many people with asthma and chronic obstructive pulmonary disease (COPD) use rescue inhalers to treat sudden breathing troubles.

  • Rescue inhalers typically contain either albuterol or levalbuterol. They can help treat exacerbations (condition flare-ups) and be easily transported.

  • Rescue inhalers all have similar side effects. These can include a fast heart rate, shakiness, and dizziness.

  • There are many ways to save on your rescue inhalers. Many options are available as lower-cost generics or have copay savings opportunities. GoodRx can help make your prescription more affordable.

Senior woman using inhaler.
Gorica Poturak/iStock via Getty Images Plus

Asthma and chronic obstructive pulmonary disease (COPD) are the two most common lung conditions in the U.S. They usually require long-term treatment with medication. Inhalers tend to be a go-to since the medication is released directly into the lungs and doesn’t get absorbed much by the rest of the body. This lowers the possibility of side effects and interactions.

While the specific medications can vary, people with asthma or COPD often require a rescue inhaler to help when they have sudden difficulty breathing. There are several prescription options on the market, and they contain either albuterol or levalbuterol. Read on to learn more about their differences and similarities.

What is a rescue inhaler?

A rescue inhaler is an inhaler that contains a fast-acting medication to help with sudden trouble breathing. Both asthma and COPD can cause sudden difficulty breathing, called an exacerbation. For people with asthma, they may refer to this as an asthma attack.

Rescue inhalers work by relaxing and opening the airways. They kick in within minutes of taking them. And their effects typically last for about 4 to 6 hours.

What types of rescue inhalers are available?

There are two rescue inhaler medications that are commonly used in the U.S.: albuterol and levalbuterol. They work similarly, but they come in many different inhaler versions. With some, you’ll see the abbreviation HFA, which stands for hydrofluoroalkane. This is a propellant which turns the medication into a fine mist that you can inhale.

Not all rescue inhalers use propellants, though. Some deliver the medication using a fine powder instead. These are called dry powder inhalers (DPIs). DPIs can be helpful for people who have trouble timing their breaths with traditional inhalers, such as children and people with mobility issues.

The following are brand names of albuterol inhalers:

Xopenex HFA is the only currently available brand name for levalbuterol. This rescue inhaler also has a generic version available.

How do rescue inhalers work?

When you breathe, air travels through many different tubes within your lungs, which eventually brings oxygen to your bloodstream. These are called the bronchial tubes, or bronchi. Trouble breathing — a hallmark in asthma and COPD — is caused by the bronchi tightening (bronchospasm).

Bronchospasms can cause:

  • Coughing

  • Shortness of breath

  • Wheezing

  • Trouble breathing overall

How do albuterol and levalbuterol work?

Albuterol and levalbuterol belong to the class of medications called short-acting beta agonists (SABAs). These medications attach to receptors (chemical binding sites) in the airways. Once activated by the medication, the receptors signal the airways to relax and open up, making breathing much easier.

When are albuterol and levalbuterol inhalers used for asthma and COPD?

Both albuterol and levalbuterol inhalers can be prescribed to people ages 4 years and older with bronchospasms caused by asthma or COPD. Albuterol inhalers are also FDA approved for exercise-induced bronchospasms or difficulty breathing during intense physical exercise. Taking albuterol 15 to 30 minutes before you exercise can help prevent breathing issues.

Both medications are meant to be used as needed for asthma- or COPD-related breathing problems. They are not intended for everyday use as long-term maintenance treatment.

How do I use albuterol and levalbuterol inhalers?

It depends on the inhaler design. The instructions for individual inhalers are provided in their packages. GoodRx Health provides a helpful video demonstrating how to use the most common inhalers. You can also check out our other article on how to use DPIs for more detailed directions for powder-based inhalers. You can also talk to your healthcare provider or pharmacist about how to use these inhalers.

Your healthcare team can help you with tips for:

  • Setting up the device

  • Preparing the medication for use

  • Storing it

  • Cleaning it

  • Using proper inhalation technique

What is the typical dose for rescue inhalers?

Rescue inhalers typically require two inhalations by mouth every 4 to 6 hours. You should wait 60 seconds between each inhalation for better absorption. Some people may only need one inhalation for either inhaler.

Your healthcare provider will help you determine your daily maximum number of doses. Using rescue inhalers like albuterol or levalbuterol more frequently than recommended generally leads to more side effects. If you find yourself needing albuterol or levalbuterol more often than prescribed, talk to your healthcare provider to find a better option for managing your symptoms.

What are the most common side effects of rescue inhalers?

People who use rescue inhalers typically have mild or no side effects, but a few potential ones are worth mentioning. Keep in mind that this is not a complete list of side effects that can happen with these medications.

  • Throat irritation. Because these medications are inhaled, they may cause throat irritation as they pass into the lungs. A drink of water after the inhalation should help relieve the irritation.

  • Rapid heart rate. For some people, these medications can increase their heart rate. This may be more noticeable with albuterol, or if you use either medication more than every 4 to 6 hours.

  • Headache and dizziness. Both medications can cause blood vessels to narrow, possibly leading to headache or dizziness.

  • Hyperactivity or tremor. Because rescue inhalers can cause blood vessels to constrict, they may make you feel more hyperactive or cause shaky hands. Again, this generally occurs when too much of the medication is taken.

  • Anxiety or nervousness. This can go hand-in-hand with a fast heart rate or tremors. Some people also experience an anxious feeling with rescue inhalers. This is typically temporary and will pass quickly.

Researchers don’t know for sure whether levalbuterol or albuterol causes more side effects. Clinicians are still debating this topic, and research is inconclusive. However, levalbuterol is thought to be less bothersome because it acts mainly on the lungs, while albuterol is more likely to affect other parts of the body.

Do albuterol and levalbuterol inhalers have any interactions?

Rescue inhalers have a lower risk of medication interactions compared to oral versions of the medications because they’re not greatly absorbed throughout the entire body. One interaction worth highlighting is with beta blockers (like atenolol and propranolol). Beta blockers are often prescribed to treat heart problems or high blood pressure. Albuterol and levalbuterol can potentially make them less effective. And on the flip side, beta blockers can make rescue inhalers less effective.

Other notable rescue inhaler interactions include:

  • Loop diuretics (“water pills”) like furosemide (Lasix)

  • Thiazide diuretics like hydrochlorothiazide

  • Digoxin (Lanoxin, Digitek)

  • Tricyclic antidepressants like amitriptyline

  • Monoamine oxidase inhibitors like selegiline (Zelapar, Emsam)

Talk to your healthcare provider and pharmacist about what other medications may interact with rescue inhalers to get further guidance.

Do albuterol and levalbuterol inhalers require any special monitoring?

No. Some medications require that you take special tests to let your healthcare provider know if they need to adjust your dosing. That’s not the case with albuterol and levalbuterol inhalers. Usually, no special tests are needed with these inhalers in addition to your routine checkups and testing related to asthma and COPD.

Who should not take albuterol and levalbuterol inhalers?

Children under the age of 4 generally should not be using these inhalers. This is because such young children may not be able to follow the instructions to ensure proper medication delivery to the lungs. They should instead use a nebulizer.

Otherwise, unless you know you have serious allergies (like if you’ve experienced hives or a swollen throat) to these medications, they are relatively safe to take. 

How to save on rescue inhalers

There are many ways to save on your rescue inhalers. GoodRx can help you navigate your options, which may include GoodRx discounts, copay savings cards, and patient assistance programs. You can find rescue inhaler prices as low as $11 with a free GoodRx discount.

The bottom line

Overall, rescue inhalers like albuterol and levalbuterol are useful medications if you have asthma or COPD and have trouble breathing. They belong to the same class of medications, so they work similarly. Some healthcare providers believe that levalbuterol has fewer side effects, but current research suggests they both have similar rates of side effects. Discuss which rescue inhaler would be best for you with your healthcare provider. 


American Academy of Allergy Asthma & Immunology. (2023). Short-acting beta-agonists (SABAs).   

Asthma and Allergy Foundation of America. (n.d.). Asthma treatment.

View All References (15)

Food and Drug Administration. (2018). Transition from CFC propelled albuterol inhalers to HFA propelled albuterol inhalers: Questions and answers.

Jat, K. R., et al. (2013). Levalbuterol versus albuterol for acute asthma: A systematic review and meta-analysis. Pulmonary Pharmacology & Therapeutics

Johnson, D. B., et al. (2022). Albuterol. StatPearls.   

MedlinePlus. (2016). Levalbuterol oral inhalation.

Nemours TeensHealth. (n.d.). Definition: Bronchoconstriction.

Nemours TeensHealth. (2019). Lungs and respiratory system.

Office of Disease Prevention and Health Promotion. (n.d.). Respiratory disease.

Proficient Rx LP. (2022). Levalbuterol tartrate HFA inhalation [package insert].

Proficient Rx LP. (2023). Albuterol sulfate [package insert].

RemedyRepack Inc. (2022). Ventolin HFA [package insert].

Sandoz. (2022). Proventil HFA [package insert].

Sunovion Pharmaceuticals Inc. (2020). Xopenex HFA [package insert].

Teva Respiratory, LLC. (2020). Proair HFA [package insert].

Teva Respiratory, LLC. (2020). Proair respiclick [package insert].

Teva Respiratory, LLC. (2022). Proair digiHaler [package insert].

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

Was this page helpful?

Let's Help You Breathe Better!

Sign up for our GoodRx Health Asthma and Allergies Newsletter to receive up-to-date information on the latest medications, treatments, and savings that are most relevant to you.

By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

Wordmark logo (w/ dimension values)
GoodRx FacebookGoodRx InstagramGoodRx Twitter
Legitscript ApprovedPharmacyBBB Accredited Business
provider image
Welcome! You’re in GoodRx Provider Mode. Now, you’ll enjoy a streamlined experience created specifically for healthcare providers.