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Atrovent vs. Advair

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ipratropium (Atrovent HFA) and fluticasone/salmeterol (Advair) are both prescription medications, but they serve different purposes and belong to different drug classes. Atrovent HFA is an inhaled anticholiergic medication used as maintenance treatment for chronic obstructive pulmonary disease (COPD). It works by blocking acetylcholine in the lungs, which allows the muscles in your airway to relax, making it easier to breathe. Advair is an inhaler that combines fluticasone, an inhaled corticosteroid, and salmeterol, a long-acting beta agonist (LABA). Advair is used for the maintenance treatment of asthma and COPD by reducing inflammation and relaxing lung muscles. Atrovent HFA is only available as a brand name medication, while Advair is available in both brand and generic forms. Atrovent HFA is typically used four times a day, whereas Advair is used twice daily. Common side effects of Atrovent HFA include cough and headache, while Advair can cause upper respiratory infections and sore throat. Additionally, Advair requires rinsing your mouth after use to prevent fungal infections, a step not needed with Atrovent HFA.

ipratropium nasal spray

 

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Advair

(fluticasone / salmeterol)

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Summary for Atrovent

Prescription only

Ipratropium nasal spray is a prescription nasal spray used to treat runny nose from allergies and from the common cold. Depending on the strength, it can be used in people ages 5 or 6 years and older. It's only available as a generic medication since the brand name, Atrovent, has been discontinued. Dosing for ipratropium nasal spray typically ranges from 2 sprays in each nostril, 2 to 4 times daily. Although most people experience few to no side effects while using ipratropium nasal spray, some people might have headache or nosebleeds during treatment.

Indications for Atrovent

  • Runny nose due to year-round allergies, seasonal allergies, and the common cold

Pros and Cons for Atrovent

Pros

  • Starts to work in as quickly as 15 minutes
  • Available as a lower-cost generic medication
  • Safe to use for children 5 or 6 years of age and older

Cons

  • Not sure if safe or works well in people with kidney or liver conditions
  • Needs to be used multiple times a day
  • Might worsen certain medical conditions, such as glaucoma or prostate problems

Common Side Effects for Atrovent

Ipratropium 0.06% nasal spray

Ipratropium 0.03% nasal spray

  • Headache (10%)
  • Cough, runny nose, and other symptoms of respiratory infections (10%)
  • Nosebleed (9%)
  • Sore throat (8%)
  • Dry nose (5%)

Warnings for Atrovent

  • Allergic reactions
  • Vision and eye problems
  • Worsening of certain medical conditions

Summary for Advair

Prescription only

Advair is a combination inhaler that contains fluticasone (an inhaled corticosteroid) and salmeterol (a long-acting beta agonist, or LABA). Advair Diskus is used for maintenance treatment of chronic obstructive pulmonary disease (COPD) and asthma in adults and children, where as Advair HFA is for asthma only. Advair (fluticasone / salmeterol) is inhaled through the mouth, typically 1 to 2 puffs twice daily. Some common side effects of this medication include upper respiratory tract infection, sore throat, and headache.

Indications for Advair

  • Maintenance treatment of asthma
  • Maintenance treatment of COPD - Advair Diskus 250/50 only

Pros and Cons for Advair

Pros

  • Works well to lower the risk of asthma or COPD symptoms
  • Combines two medications into a single inhaler for convenience
  • Available as two different types of inhalers (Advair Diskus and Advair HFA)

Cons

  • Can cause fungal infections (thrush) in your mouth and throat
  • Advair Diskus contains lactose, so it might not be safe for people with severe milk protein allergies
  • Doesn't replace your rescue inhaler

Common Side Effects for Advair

Advair Diskus:

  • Upper respiratory infection (up to 27%)
  • Sore throat (up to 13%)
  • Headache (up to 13%)
  • Bronchitis (up to 8%)
  • Cough (up to 6%)
  • Nausea and vomiting (up to 6%)
  • Hoarseness (up to 5%)

Advair HFA:

  • Upper respiratory infection (up to 24%)
  • Headache (up to 21%)
  • Throat irritation (up to 9%)
  • Muscle and bone pain (up to 7%)
  • Nausea and vomiting (up to 5%)

Warnings for Advair

  • Not for use in asthma attack or for worsening breathing
  • Fungal infection in the mouth
  • Narrowing of your airways (bronchospasm)
  • Higher risk of infections
  • Altered stress hormone levels
  • Delayed growth in children
  • Eye and vision problems
  • Heart problems
  • Low potassium levels in the blood
  • Allergic reactions

Prices with our coupons for Atrovent vs. Advair

Price Card Drug Icon
Ipratropium25 vials / 2.5ml of 0.02%
$14.40$77.09
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Price Card Drug Icon
Fluticasone/Salmeterol1 diskus inhaler / 250mcg/50mcg
$64.54$314.99
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