Compare Flonase vs. Zyrtec

Flonase (fluticasone) and Zyrtec (cetirizine) are both used to treat allergy symptoms, but they have several differences. Flonase is a corticosteroid nasal spray that reduces inflammation in your nose to relieve symptoms like congestion, runny nose, and sneezing. It is available both by prescription and over-the-counter (OTC). On the other hand, Zyrtec is an antihistamine taken orally, either as a tablet or liquid, that blocks histamine to relieve symptoms like itchy eyes, runny nose, and sneezing. Zyrtec is also available in generic form and can be taken once a day. While Flonase is used daily and can take several days to show full benefits, Zyrtec starts working within 20 to 60 minutes. Flonase can cause side effects like nosebleeds and sore throat, while Zyrtec can make you sleepy and cause dry mouth. Additionally, Flonase is safe for children as young as 2 years old in some formulations, whereas Zyrtec is not recommended for children under 6 years old in pill form.