Compare Flonase vs. Nyquil

Flonase (fluticasone) and Nyquil (acetaminophen/dextromethorphan/doxylamine) are both used to treat symptoms related to allergies and colds, but they work in different ways and are used for different purposes. Flonase is a nasal spray that contains fluticasone (corticosteroid), and it's used to treat allergy symptoms like congestion, runny nose, and itchy eyes. It reduces inflammation in your nose and is available both by prescription and over-the-counter (OTC). Nyquil, on the other hand, is an oral medication that combines acetaminophen (a pain reliever), dextromethorphan (a cough suppressant), and doxylamine (an antihistamine). It is used to relieve cold and flu symptoms such as cough, sore throat, and fever. Nyquil can make you sleepy and is available OTC in both liquid and capsule forms. While Flonase is used daily for ongoing allergy relief, Nyquil is taken multiple times a day for short-term relief of cold and flu symptoms. Additionally, Flonase is not recommended for use if you have a nasal injury or recent surgery, whereas Nyquil should be avoided if you have liver disease or are taking other medications containing acetaminophen.