Compare Patanase vs. Flonase

Olopatadine (Patanase) and fluticasone (Flonase, Flonase Sensimist) are both nasal sprays used to treat allergy symptoms like a runny or stuffy nose. However, they belong to different medication classes. Olopatadine works by blocking histamine, a chemical responsible for allergy symptoms. Fluticasone is a corticosteroid that reduces inflammation in the nose. Olopatadine is available by prescription only, while fluticasone can be purchased over-the-counter or with a prescription. Olopatadine is typically used twice a day, while fluticasone is usually taken once a day. Olopatadine rarely causes side effects, but can cause nosebleeds or nose sores. Fluticasone can also cause nosebleeds and may lead to slower growth in children if used for more than two months. Both medications are available as a brand and a lower-cost generic.