Compare Afrin vs. Flonase
Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Oxymetazoline (Afrin) and fluticasone (Flonase) are both nasal sprays, but they work differently and are used for different purposes. Oxymetazoline is an alpha-1 receptor agonist that provides short-term relief for nasal and sinus congestion by tightening blood vessels in your nose. It works quickly, within minutes, but should not be used for more than 3 days to avoid rebound congestion. On the other hand, fluticasone is a corticosteroid used to treat allergy symptoms like runny nose, sneezing, and itchy eyes by reducing inflammation. Fluticasone needs to be used daily for the best results and can be used for up to 6 months (or 2 months for children) without consulting a healthcare provider. While oxymetazoline is available over-the-counter, fluticasone is available OTC and by prescription, and it can have more serious side effects if used long-term, such as nosebleeds and slowed growth in children. Both medications come in different formulations and strengths, so it's important to follow the specific instructions for each.
- Oxymetazoline (Afrin)Fluticasone nasal spray
- Oxymetazoline (Afrin)Fluticasone nasal spray
Summary of Afrin vs. Flonase
Summary for Alpha adrenergic receptor agonistOxymetazoline (Afrin) is a nasal decongestant spray. More specifically, it's an alpha-1 receptor agonist. Oxymetazoline (Afrin) is sprayed into the nostrils up to twice daily to help relieve stuffy noses. But you should avoid using it for longer than 3 days in a row because doing so can raise the risk for rebound congestion. There are oxymetazoline products for children and adults that differ in dosage, so read the label on your specific product to make sure it's appropriate for you. Some side effects of this medication might include mild burning or stinging in the nose.
Summary for CorticosteroidFluticasone nasal spray is used to treat allergy symptoms, like runny nose and sneezing. Fluticasone nasal spray comes in brand and generic forms, and is available by a prescription or over-the-counter (OTC). Fluticasone nasal spray must be used daily in order for you to experience the maximum benefits. But if you're using OTC versions of this medication, don't use it for more than 6 months at a time (or 2 months at a time, for children) without first speaking to your provider.
Indications of Afrin vs. Flonase
Indications for•Short-term relief of nasal and sinus congestion and pressureIndications forNasal symptoms from allergies, such as:
•Congestion•Runny nose•Sneezing•Itchy nose•Itchy, watery eyesPros and Cons of Afrin vs. Flonase
Pros and Const for Alpha adrenergic receptor agonistPros•Starts working within minutes and lasts for up to 12 hours•Typically fewer side effects than oral decongestants•Children's product can be used by those as young as 2 years old (check product labeling)•Available over the counter and as a lower-cost genericCons•Some nasal spray might drip out of nose, which can be messy•Can't use longer than 3 days due to rebound congestion•Might not be a good choice for people with high blood pressure•Not recommended during pregnancyPros and Const for CorticosteroidPros•Only has to be used once a day and can last up to 24 hours•Available OTC•Some formulations have generic versions•Can be used safely in children as young as 4 years old•Flonase Sensimist is a gentler version that can be used in children as young as 2 years oldCons•Not a good option if you have an injured nose or had recent nasal surgery•Can raise the risk of bleeding and fungal infections in the nose•Can slow down growth rate in children if used for longer than 2 months per year•Can raise the risk for certain eye problemsCommon Side Effects of Afrin vs. Flonase
Common Side Effects for•Burning in the nose•Stinging in the nose•Rebound nasal congestion (if using longer than 3 days)Common Side Effects for•Headache (7-16%)•Sore throat (6-8%)•Nosebleeds (6-7%)•Asthma symptoms (3-7%)Warnings of Afrin vs. Flonase
Common Side Effects for•Rebound congestion•Might not be safe for people with certain medical conditions•For use in the nose onlyCommon Side Effects for•Nasal problems•Slowed growth rate in children•Eye problems•Higher risk of infections•Stress hormone problems (adrenal gland problems)•Serious allergic reactionsPrices with our coupons for Afrin vs. Flonase
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