Oxymetazoline (Afrin) is a nasal decongestant spray. More specifically, it's an alpha-1 receptor agonist. Oxymetazoline (Afrin) is sprayed into the nostrils up to twice daily to help relieve stuffy noses. But you should avoid using it for longer than 3 days in a row because doing so can raise the risk for rebound congestion. There are oxymetazoline products for children and adults that differ in dosage, so read the label on your specific product to make sure it's appropriate for you. Some side effects of this medication might include mild burning or stinging in the nose.
Short-term relief of nasal and sinus congestion and pressure
Oxymetazoline (Afrin) is an alpha-1 receptor agonist. It works by attaching to receptors in your nose and sinuses. This causes the blood vessels in your nose and sinuses to tighten, which relieves nasal swelling and congestion. So oxymetazoline (Afrin) makes it easier for you to breathe through your nose.
Source: DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
When this medicine is used for short periods of time at low doses, side effects usually are rare.
Check with your doctor as soon as possible if any of the following side effects occur:
With overuse or long-term use
Increase in irritation or redness of eyes
Symptoms of too much medicine being absorbed into the body
Fast, irregular, or pounding heartbeat
headache or lightheadedness
nervousness
trembling
trouble in sleeping
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Starts working within minutes and lasts for up to 12 hours
Typically fewer side effects than oral decongestants
Children's product can be used by those as young as 2 years old (check product labeling)
Available over the counter and as a lower-cost generic
Some nasal spray might drip out of nose, which can be messy
Can't use longer than 3 days due to rebound congestion
Might not be a good choice for people with high blood pressure
Not recommended during pregnancy
Some people might experience temporary discomforts, such as stinging or sneezing, right after using oxymetazoline (Afrin). These side effects are typically mild and go away after a while. But if they're bothersome and don't go away, let your primary care provider (PCP) know because you might need to stop using this spray.
Don't use oxymetazoline (Afrin) longer than 3 days because doing so can cause your congestion to come back or get worse. If your symptoms don't get better after 3 days, talk with your PCP about other treatment options, including home remedies.
If oxymetazoline (Afrin) isn't enough to ease your congestion, ask your PCP about other nasal sprays, such as fluticasone (Flonase) or sodium chloride (Ocean Nasal Spray). These medications work differently than oxymetazoline (Afrin). Your PCP might recommend one of these in addition to oxymetazoline (Afrin), depending on how severe your congestion is and what other health conditions you might have.
Don't take medications that are similar to oxymetazoline (Afrin), such as phenylephrine (Neo-Synephrine) nasal spray or pseudoephedrine (Sudafed) oral tablets, together with oxymetazoline (Afrin). Doing so raises your risk for side effects without helping your congestion more. Before picking up any OTC nasal congestion medications, check with your pharmacist or PCP to make sure they're safe for you.
How to use oxymetazoline (Afrin):
Make sure you know how to give yourself oxymetazoline (Afrin) to avoid accidentally hurting yourself or wasting the medication. Also, always check the product labeling since some instructions might be a little different.
When you first open your bottle of oxymetazoline (Afrin), prime it by spraying it into the air away from yourself and others several times until you see a full mist. You should also prime the bottle if you haven't used it in a while.
Before using oxymetazoline (Afrin), blow your nose and wash your hands with soap and water. Shake the bottle gently before each use and remove the cap. Keep your head upright and breathe in through the nose while you spray.
Always wipe the top clean after each use. Don't share oxymetazoline (Afrin) with other people to avoid spreading infections.
Oxymetazoline (Afrin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Using oxymetazoline (Afrin) for more than 3 days in a row
Don't use oxymetazoline (Afrin) for more than 3 days in a row. Doing so can lead to rebound congestion, meaning your symptoms could get worse or come back after you stop using this medication. Talk to your primary care provider or pharmacist about better long-term alternative products to help with your congestion.
Risk factors: Heart disease or high blood pressure | Thyroid problems | Diabetes (high blood sugar) | Urinary problems
Oxymetazoline (Afrin) might not be safe for people with certain medical conditions, like high blood pressure, heart disease, or diabetes. Although oxymetazoline (Afrin) doesn't raise blood pressure as much as other decongestants, it's still a safety concern, especially if you have existing high blood pressure. If you have medical conditions like those listed above, ask your primary care provider before starting oxymetazoline (Afrin).
Oxymetazoline (Afrin) should only be used in your nose. Don't give this medication any other way. If you feel a nasal spray is not the best choice for you, ask your pharmacist or primary care provider for other options to treat your congestion. Young children who accidentally swallow can get serious side effects, including breathing problems and slow heart rate. If you or someone else takes oxymetazoline (Afrin) by mouth, get medical help right away or contact a poison control center at 1-800-222-1222.
Oxymetazoline 0.05% nasal spray:
Adults and children ages 6 years and older: The typical dose is 2 or 3 sprays in each nostril, up to every 10 to 12 hours. Don't use more than 2 doses in a 24-hour period, or for longer than 3 days.
Children ages 6 years and younger: Don't use. See below for the recommended product for younger children.
Oxymetazoline 0.025% nasal spray:
Children ages 2 to under 6 years old: The typical dose is 2 or 3 sprays in each nostril, up to every 10 to 12 hours. Don't use more than 2 doses in a 24-hour period, or for longer than 3 days.
Children ages under 2 years: Ask your child's pediatrician.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Short-term relief of nasal and sinus congestion and pressure
Short-term relief of nasal and sinus congestion and pressure
Short-term relief of nasal and sinus congestion and pressure
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Bayer HealthCare LLC. (2023). CHILDREN AFRIN EXTRA MOISTURIZING STUFFY NOSE PUMP MIST STUFFY NOSE PUMP MIST - oxymetazoline hydrochloride spray, metered [package insert]. DailyMed.
Bayer HealthCare LLC. (2023). AFRIN NO DRIP SEVERE CONGESTION - oxymetazoline hydrochloride spray, metered [package insert]. DailyMed.
Bellew, S.D., et al. (2018). Effect of Intranasal Vasoconstrictors on Blood Pressure: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Emergency Medicine.
Drugs and Lactation Database (LactMed). (2021). Oxymetazoline. National Institute of Child Health and Human Development.
Kumar, R. S., et al. (2022). Efficacy and safety of Fluticasone Furoate and Oxymetazoline Nasal Spray: A novel first fixed dose combination for the management of allergic rhinitis with nasal congestion. Journal of Asthma and Allergy.
U.S. Food and Drug Administration. (2016). FDA drug safety communication: Serious adverse events from accidental ingestion by children of over-the-counter eye drops and nasal sprays.
Yau, W., et al. (2013). Use of decongestants during pregnancy and the risk of birth defects. American Journal of Epidemiology.
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