Key takeaways
Phenylephrine eye drops and Advil Cold and Sinus (ibuprofen/pseudoephedrine) are used for different purposes and have distinct characteristics. Phenylephrine eye drops are used to dilate your pupils for eye exams or procedures. Advil Cold and Sinus combines an NSAID (ibuprofen) and a decongestant (pseudoephedrine) to relieve symptoms of the common cold or flu, such as headaches, body aches, and nasal congestion. Phenylephrine eye drops are available by prescription only and can cause side effects like temporary eye stinging and blurry vision. In contrast, Advil Cold and Sinus is available over-the-counter but must be purchased from behind the pharmacy counter because it contains pseudoephedrine. Advil Cold and Sinus can cause side effects like stomach upset and difficulty sleeping. Phenylephrine eye drops are used in both adults and children, while Advil Cold and Sinus is only for those 12 years and older.
