Compare Sudafed vs. Advil Allergy and Congestion

Sudafed (pseudoephedrine) and Advil Allergy and Congestion Relief (ibuprofen/phenylephrine/chlorpheniramine) are both over-the-counter medications used to treat symptoms of allergies and the common cold, but they have some key differences. Sudafed is a single-ingredient decongestant that works by narrowing blood vessels in your nose and sinuses to relieve congestion and pressure. It comes in various formulations, including immediate-release and extended-release tablets, and is available in generic forms. On the other hand, Advil Allergy and Congestion Relief is a combination of three medications: ibuprofen (a pain reliever and anti-inflammatory), phenylephrine (a decongestant), and chlorpheniramine (an antihistamine). This combination helps relieve a wider range of symptoms, including runny nose, itchy eyes, and minor aches and pains, but it needs to be taken every 4 hours. Studies show that oral phenylephrine is not effective so Advil Allergy and Congestion Relief may not be the best option for managing congestion symptoms. Sudafed can cause side effects like anxiety and difficulty sleeping, while Advil Allergy and Congestion Relief can cause dizziness, sleepiness, and stomach issues. Additionally, Sudafed is not recommended during pregnancy, especially in the first trimester, whereas Advil Allergy and Congestion Relief should be avoided during the second half of pregnancy due to the risk of complications.