Key takeaways
Zyrtec-D (cetirizine/pseudoephedrine) and diphenhydramine (Benadryl) are both over-the-counter medications used to treat allergy symptoms, but they have some key differences. Zyrtec-D combines an antihistamine (cetirizine) and a decongestant (pseudoephedrine), making it effective for both allergies and nasal congestion. However, it can cause trouble sleeping if taken too close to bedtime and may raise your blood pressure. Diphenhydramine, on the other hand, is solely an antihistamine and is known for causing significant drowsiness, which makes it useful as a sleep aid. Unlike Zyrtec-D, diphenhydramine is not recommended for long-term use due to potential memory and confusion issues, especially in older adults. Additionally, diphenhydramine can cause hyperactivity in some children and should not be used for sleep in children under 12. Both medications are available in generic forms and come in various dosage forms, but Zyrtec-D requires a photo ID for purchase due to pseudoephedrine regulations.
