Key takeaways
Nyquil Cold and Flu (acetaminophen/dextromethorphan/doxylamine) and Tylenol Cold + Flu + Cough Night (acetaminophen/dextromethorphan/doxylamine/phenylephrine) are both over-the-counter medications used to relieve symptoms of the common cold and flu. Nyquil Cold and Flu combines a pain reliever, a cough suppressant, and an antihistamine, while Tylenol Cold + Flu + Cough Night adds a decongestant to this mix. This means Tylenol Cold + Flu + Cough Night can also help with nasal congestion and sinus pressure. Nyquil Cold and Flu is available in liquid and capsule forms, whereas Tylenol Cold + Flu + Cough Night comes in capsules, tablets, and liquid. Nyquil Cold and Flu is typically taken every 6 hours, while Tylenol Cold + Flu + Cough Night is taken every 4 hours. Both medications can cause drowsiness, but Tylenol Cold + Flu + Cough Night might also make you feel restless due to the phenylephrine. Always check the labels and consult with a healthcare provider to ensure safe use, especially if you have other health conditions or are taking other medications.
Prices with our coupons for Nyquil vs. Acetaminophen / dextromethorphan / doxylamine / phenylephrine
