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Cetirizine / Pseudoephedrine Coupon - Cetirizine / Pseudoephedrine 12 hour tablet

cetirizine / pseudoephedrine

Generic Zyrtec-D
Used for Nasal Congestion, Allergic Rhinitis
Used for Nasal Congestion, Allergic Rhinitis

Zyrtec-D is a combination medication containing cetirizine (an antihistamine) and pseudoephedrine (a decongestant). It's taken by people ages 12 years and older to relieve allergy symptoms, like runny nose and nasal congestion. This medication comes as an extended-release tablet that's taken by mouth every 12 hours. Zyrtec-D is available as a brand-name and generic medication. Side effects can include trouble sleeping and dry mouth.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on October 24, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Zyrtec-D (cetirizine / pseudoephedrine)?

What is Zyrtec-D (cetirizine / pseudoephedrine) used for?

Short-term relief of allergy symptoms in adults and children ages 12 years and older:

  • Itchy nose or throat

  • Sneezing

  • Itchy or watery eyes

  • Runny or stuffy nose

  • Sinus congestion or pressure

How Zyrtec-D (cetirizine / pseudoephedrine) works

Zyrtec-D (cetirizine / pseudoephedrine) is a combination of two medications that work together to relieve allergy symptoms.

Are you looking for information on cetirizine (Zyrtec) instead?
When does Zyrtec-D (cetirizine / pseudoephedrine) start working?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsZyrtec-D
Drug ClassAntihistamine / Decongestant
Controlled Substance ClassificationControlled in some states. See FAQs below.
Generic StatusLower-cost generic available
AvailabilityOver-the-counter
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What are the side effects of Zyrtec-D (cetirizine / pseudoephedrine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Feeling tired
  • Sleepiness
  • Sore throat
  • Dizziness
  • Sinus inflammation

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Accidentally taking too much medication: seizures, hallucinations, confusion, blurry vision, changes in mood or behavior, movement problems,
  • High blood pressure or fast heart rate: chest pain, blurry vision, headache, fatigue
When do Zyrtec-D (cetirizine / pseudoephedrine) possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Trouble sleeping
Dry mouth

Source: DailyMed

More on Zyrtec-D (cetirizine / pseudoephedrine) side effects

zyrtec-d: side effects zyrtec-d

8 Zyrtec-D Side Effects to Consider: Dry Mouth, Drowsiness, and More

Written by Sarah Morin, RPh

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of Overdose

Changes in mood, irrational behavior, depersonalization hallucinations

convulsions (seizures)

extreme sleepiness or unusual drowsiness

fast, slow, pounding, or irregular heartbeat or pulse

feeling anxious

giddiness

headache

irritability

muscle weakness or tenderness

nausea

restlessness

shallow, irregular, fast, or slow breathing

sleeplessness or trouble in sleeping

abdominal and/or chest pain

thirst

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

Breathing, troubled

back, leg, or stomach pain

blurred vision

bloody, cloudy, or dark urine, sudden decrease in amount of urine

black, tarry stools, diarrhea, light-colored stools

confusion

dizziness, feeling faint, or lightheaded

fever or chills

increased blood pressure

rapid weight gain

skin rash or hives

swelling of face, mouth, throat, fingers, glands, feet, and/or lower legs

stillbirth

twitching, twisting, or uncontrolled repetitive movements of the face

sudden sweating

vomiting blood, bleeding gums, nosebleeds, unusual bleeding or bruising

pale or yellow eyes or skin

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Sleepiness or unusual drowsiness, extreme tiredness

Less common

Dry mouth

weakness

Rare

Dizziness

sore throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Zyrtec-D (cetirizine / pseudoephedrine)

thumbs-up

Pros

Starts working within an hour

Easier to take a combination pill instead of two separate pills to treat congestion and other allergy symptoms

Available over the counter (behind the counter)

thumbs-down

Cons

Might need to take twice daily

Tablets can't be crushed or chewed and there isn't a liquid version available

Not the safest choice if you have certain conditions, like heart problems and trouble urinating

pharmacist-tips

Pharmacist tips for Zyrtec-D (cetirizine / pseudoephedrine)

pharmacist

  • Don't cut, crush, or chew the tablets. This will affect the way Zyrtec-D (cetirizine / pseudoephedrine) works since it's made to release the medication into your body slowly over time. Make sure that you swallow the tablets whole.

    • If Zyrtec-D (cetirizine / pseudoephedrine) is making you sleepy or dizzy during the day, it can affect your ability to focus, think, or react. Don't drive until you know how this medication affects you. Also, avoid alcohol while taking this medication because it can make sleepiness and dizziness worse.

      • Both cetirizine and pseudoephedrine interact with other medications. Always make sure to check with your care team first before starting any new medications while you're taking Zyrtec-D (cetirizine / pseudoephedrine). They can check for harmful interactions.

        • Just like Zyrtec-D (cetirizine / pseudoephedrine), many other OTC allergy, cold, and flu medications can contain an antihistamine or decongestant. Taking too many decongestant or antihistamine medications at the same time can raise your risk of overdose and severe and life-threatening side effects, such as very high blood pressure, fast heart rate, seizures, and hallucinations (seeing things that aren't real).

          • Stop taking Zyrtec-D (cetirizine / pseudoephedrine) and contact your primary care provider if you get side effects like nervousness, dizziness, or trouble sleeping. Also stop taking the medication and let your primary care provider know if your symptoms don't get better within 7 days of starting Zyrtec-D (cetirizine / pseudoephedrine) or if you develop a fever. These might be signs of another medical condition that's going on.

            • Store Zyrtec-D (cetirizine / pseudoephedrine) up and away from children and pets. That way, they're less likely to reach it and accidentally take the medication. If you think your child accidentally took the medication, call a Poison Control Center right away at 1-800-222-1222.

              • If you're pregnant or breastfeeding, don't take Zyrtec-D (cetirizine / pseudoephedrine) until you've talked to a healthcare professional first. There's limited information on how safe it is to take pseudoephedrine during pregnancy. And there's a risk that taking pseudoephedrine while nursing can dry up breast milk supply.

                faqs

                Frequently asked questions about Zyrtec-D (cetirizine / pseudoephedrine)

                What is the "D" in Zyrtec-D?
                The "D" in Zyrtec-D stands for "decongestant" because it contains pseudoephedrine, a nasal decongestant.
                What's the difference between Zyrtec-D and Zyrtec?
                Zyrtec-D is a combination of two medications: an antihistamine (cetirizine) that treats symptoms like runny nose or watery eyes, and a nasal decongestant (pseudoephedrine). Zyrtec only contains cetirizine, an antihistamine. If you're experiencing nasal or sinus congestion and pressure in addition to other typical allergy symptoms, your pharmacist might recommend Zyrtec-D (cetirizine / pseudoephedrine) over Zyrtec (cetirizine).
                How long can you take Zyrtec-D (cetirizine / pseudoephedrine)?
                Ask your healthcare team how long you can take Zyrtec-D (cetirizine / pseudoephedrine). The manufacturer doesn't set a time limit on how long you can take this medication. But they recommend that you contact your primary care provider if your allergy symptoms haven't improved after taking Zyrtec-D (cetirizine / pseudoephedrine) for a week, or if you develop a fever; these might be signs that you need more medical attention. Also, because the pseudoephedrine in Allegra-D can affect your blood pressure and heart rate, your healthcare team might recommend a different option if you need to take an allergy medication long-term.
                Where can I buy Zyrtec-D (cetirizine / pseudoephedrine)?
                You can find Zyrtec-D (cetirizine / pseudoephedrine) at most local pharmacies at the pharmacy counter (or behind the counter). You'll be asked to present photo identification and sign when you buy it. There are strict regulations around this medication because it contains pseudoephedrine, which can potentially be misused. Some states consider Zyrtec-D (cetirizine / pseudoephedrine) a controlled substance. Ask your pharmacist if you have questions about how to purchase Zyrtec-D (cetirizine / pseudoephedrine) in the pharmacy.
                Does Zyrtec-D (cetirizine / pseudoephedrine) make you sleepy?
                Though not common, some people might feel sleepy after taking Zyrtec-D (cetirizine / pseudoephedrine) because of the cetirizine. But studies show that this medication is more likely to cause trouble sleeping because of the pseudoephedrine. Pay attention to how Zyrtec-D (cetirizine / pseudoephedrine) affects your sleep when you first start taking this medication. Contact your primary care provider to discuss better options for you if it's making you too sleepy or interrupting your sleep and affecting your daily activities.
                Can you take Mucinex and Zyrtec-D (cetirizine / pseudoephedrine) together?
                You might be able to take Mucinex and Zyrtec-D (cetirizine / pseudoephedrine) together, depending on the Mucinex product. Mucinex isn't a single medication, but a brand name that makes multiple products to treat cold and flu symptoms. You should avoid taking Zyrtec-D (cetirizine / pseudoephedrine) with a Mucinex product that also contains an antihistamine or a decongestant. Taking too many similar medications together can raise your risk for serious side effects, such as high blood pressure, headache, and trouble urinating. Ask your pharmacist if you're not sure whether you can take a specific Mucinex product with Zyrtec-D (cetirizine / pseudoephedrine).
                What's the difference between Allegra-D, Claritin-D, and Zyrtec-D?
                Allegra-D, Claritin-D, and Zyrtec-D are all combination medications that contain pseudoephedrine and an antihistamine. But the specific antihistamine in each medication differs: Allegra-D contains fexofenadine, Claritin-D contains loratadine, and Zyrtec-D contains cetirizine. All three antihistamines work similarly well in treating allergy symptoms, but they slightly differ in how quickly they start to work and their potential side effects. Talk to your pharmacist or primary care provider if you have specific questions on the differences of each product.
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                What are the risks and warnings for Zyrtec-D (cetirizine / pseudoephedrine)?

                Zyrtec-D (cetirizine / pseudoephedrine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Fast heart rate and high blood pressure

                • Risk factors: Heart problems | High blood pressure

                  Pseudoephedrine in Allegra-D can raise your heart rate and blood pressure, even at recommended doses. If you have a history of heart problems or high blood pressure, ask your cardiologist if Zyrtec-D (cetirizine / pseudoephedrine) is safe for you before using this medication. If you get severe headaches, nosebleeds, difficulty breathing, irregular heartbeat, or chest pain while taking Zyrtec-D (cetirizine / pseudoephedrine), stop taking it and get medical attention right away. These can be signs of dangerously high blood pressure.

                  risk-warning

                  Worsening of certain medical conditions

                  • Risk factors: Heart problem | High blood pressure | Thyroid problem | High blood sugar (diabetes) | Glaucoma | Urinary condition | Liver problems | Kidney problems

                    Talk with your primary care provider or pharmacist first before you use Zyrtec-D (cetirizine / pseudoephedrine) if you have other medical conditions. They can make sure this medication is safe and appropriate for you to take.

                    People who are 65 years of age or older might feel side effects from Zyrtec-D (cetirizine / pseudoephedrine) more intensely. In addition, this medication might worsen certain medical conditions, like high blood pressure, thyroid problems, diabetes, glaucoma, and urinary problems.

                    risk-warning

                    Accidentally taking too much medication

                    Zyrtec-D contains an antihistamine (cetirizine) and a decongestant (pseudoephedrine). Antihistamines and decongestants are commonly found in many other over-the-counter and prescription products.

                    Taking too many antihistamines or too many decongestants can be dangerous and lead to serious side effects, including high blood pressure, seizures, and hallucinations (seeing or hearing things that aren't real).

                    Ask your primary care provider or pharmacist if you're not sure whether you're taking a medication that has the same or similar ingredients as Zyrtec-D (cetirizine / pseudoephedrine). Tell your care team about the medications you take or plan to take to make sure they're safe for you. Get medical help or contact a Poison Control Center at 1-800-222-1222 right away if you think you or a loved one accidentally took too much medication.

                    dosage

                    Zyrtec-D (cetirizine / pseudoephedrine) dosage forms

                    The average cost for 60 tablets of 12 hour of Zyrtec-D (cetirizine / pseudoephedrine) is $23.42 with a free GoodRx coupon. This is 43.05% off the average retail price of $41.12.
                    tablet
                    Tablet
                    DosageQuantityPrice as low asPrice per unit
                    12 hour24 tablets$23.42$0.98

                    Typical dosing for Zyrtec-D (cetirizine / pseudoephedrine)

                    For Zyrtec-D: Each tablet contains 5 mg of cetirizine and 120 mg of pseudoephedrine.

                    • Adults and children ages 12 to under 65 years: The typical dose is 1 tablet by mouth every 12 hours. Don't take more than 2 tablets in a 24-hour period.

                    • Age under 12 years: Ask your child's pediatrician.

                    • Age 65 years and older: Ask your primary care provider.

                    Your dose might differ if you have kidney or liver problems.

                    More on Zyrtec-D (cetirizine / pseudoephedrine) dosage forms

                    Zyrtec: zyrtec dosage

                    Zyrtec and Zyrtec-D Dosages: Your GoodRx Guide

                    Written by Timothy Aungst, PharmD
                    interactions

                    Interactions between Zyrtec-D (cetirizine / pseudoephedrine) and other drugs

                    Zyrtec-D (cetirizine / pseudoephedrine) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Zyrtec-D (cetirizine / pseudoephedrine). Please note that only the generic name of each medication is listed below.

                    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                    How much does Zyrtec-D (cetirizine / pseudoephedrine) cost?

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                    Zyrtec-D (brand)
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                    contraindications-icon

                    Zyrtec-D (cetirizine / pseudoephedrine) contraindications

                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Zyrtec-D (cetirizine / pseudoephedrine) will not be safe for you to take.
                    alternatives

                    What are alternatives to Zyrtec-D (cetirizine / pseudoephedrine)?

                    There are a number of medications that your doctor can prescribe in place of Zyrtec-D (cetirizine / pseudoephedrine). Compare a few possible alternatives below.
                    Zyrtec-D (cetirizine / pseudoephedrine)
                    Used for:

                    Short-term relief of allergy symptoms in adults and children ages 12 years and older:

                    • Itchy nose or throat

                    • Sneezing

                    • Itchy or watery eyes

                    • Runny or stuffy nose

                    • Sinus congestion or pressure

                    $23.42 Lowest GoodRx priceView Prices
                    Claritin-D (loratadine / pseudoephedrine)
                    Used for:

                    • Runny nose

                    • Itchy nose or throat

                    • Itchy or watery eyes

                    • Stuffy nose

                    • Nasal congestion

                    • Sinus congestion or pressure

                    $13.61 Lowest GoodRx priceView Prices
                    Allegra-D (fexofenadine / pseudoephedrine)
                    Used for:

                    • Itchy nose or throat

                    • Sneezing

                    • Itchy or watery eyes

                    • Runny or stuffy nose

                    • Sinus congestion or pressure

                    $22.65 Lowest GoodRx priceView Prices
                    latest news

                    What is the latest news about Zyrtec-D (cetirizine / pseudoephedrine)?

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                    When allergies strike, you might want double defense. But does that mean you can take both Zyrtec and Sudafed, at the same time? Find out here.

                    Sudafed and Zyrtec: Can You Take Them Together?

                    When allergies strike, you might want double defense. But does that mean you can take both Zyrtec and Sudafed, at the same time? Find out here.
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                    Allergy Medicine: Comparing the Best OTC Allergy Medications

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                    Zyrtec-D is an antihistamine-decongestant combination for allergy symptoms. Learn about potential Zyrtec D side effects and how to manage them.

                    8 Zyrtec-D Side Effects to Consider: Dry Mouth, Drowsiness, and More

                    Zyrtec-D is an antihistamine-decongestant combination for allergy symptoms. Learn about potential Zyrtec D side effects and how to manage them.
                    Read on for Zyrtec dosage information, including typical dosage, adjustments for health conditions, and what to do if you miss a dose.

                    Zyrtec and Zyrtec-D Dosages: Your GoodRx Guide

                    Read on for Zyrtec dosage information, including typical dosage, adjustments for health conditions, and what to do if you miss a dose.
                    Here are the top pseudoephedrine interactions to avoid, including tricyclic antidepressants, some types of headache medications, and caffeine.

                    10 Pseudoephedrine (Sudafed) Interactions You Should Know About

                    Here are the top pseudoephedrine interactions to avoid, including tricyclic antidepressants, some types of headache medications, and caffeine.
                    What can cause your breast milk to dry up? Sudafed (pseudoephedrine), Clomid (clomiphene), and estrogen-containing birth control are all possible causes.

                    3 Medications That Can Dry Up Your Breast Milk Supply

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                    Medications that are likely to cause constipation include opioids, antidepressants, antihistamines, and high blood pressure medications. Dietary changes and stool softeners can help bring some relief.

                    8 Types of Medications That Can Cause Constipation

                    Medications that are likely to cause constipation include opioids, antidepressants, antihistamines, and high blood pressure medications. Dietary changes and stool softeners can help bring some relief.
                    images

                    Zyrtec-D (cetirizine / pseudoephedrine) images

                    White Round L147 - GoodSense All Day Allergy 5mg-120mg Extended-Release Tablet
                    This medicine is White, Round Tablet Imprinted With "L147".White Round L147 - GoodSense All Day Allergy 5mg-120mg Extended-Release Tablet
                    White And Yellow Round Logo 5029 And 5 / 120 - GoodSense All Day Allergy-D 12 Hour 5mg-120mg Extended-Release Tablet
                    This medicine is White And Yellow, Round Tablet Imprinted With "Logo 5029" And "5 / 120".White And Yellow Round Logo 5029 And 5 / 120 - GoodSense All Day Allergy-D 12 Hour 5mg-120mg Extended-Release Tablet
                    Yellow Round Sz 912 - Cetirizine Hydrochloride / Pseudoephedrine Hydrochloride 12 Hour 5mg-120mg Extended-Release Tablet
                    This medicine is Yellow, Round Tablet Imprinted With "Sz 912".Yellow Round Sz 912 - Cetirizine Hydrochloride / Pseudoephedrine Hydrochloride 12 Hour 5mg-120mg Extended-Release Tablet
                    White Round Logo 5029, 5 / 120, And L147 - Cetirizine Hydrochloride / Pseudoephedrine Hydrochloride 5mg-120mg Extended-Release Tablet
                    This medicine is White, Round Tablet Imprinted With "Logo 5029", "L147", And "5 / 120".White Round Logo 5029, 5 / 120, And L147 - Cetirizine Hydrochloride / Pseudoephedrine Hydrochloride 5mg-120mg Extended-Release Tablet
                    White Round Logo 5029, 5 / 120, And L147 - Cetirizine Hydrochloride / Pseudoephedrine Hydrochloride 5mg-120mg Extended-Release Tablet
                    This medicine is White, Round Tablet Imprinted With "Logo 5029", "L147", And "5 / 120".White Round Logo 5029, 5 / 120, And L147 - Cetirizine Hydrochloride / Pseudoephedrine Hydrochloride 5mg-120mg Extended-Release Tablet
                    white and yellow round - CVS Allergy Relief-D 12 Hour 5mg-120mg Extended-Release Tablet
                    This medicine is White And Yellow, Round Tablet.white and yellow round - CVS Allergy Relief-D 12 Hour 5mg-120mg Extended-Release Tablet

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                    References

                    Best studies we found

                    Aurohealth LLC. (2024). Cetirizine hydrochloride and pseudoephedrine hydrochloride tablet, film coated, extended release [package insert]. DailyMed.

                    Głowacka, K., et al. Pseudoephedrine—Benefits and risks. International Journal of Molecular Sciences.

                    Kenvue Brands LLC. (2024). Zyrtec-D Allergy Plus Congestion- cetirizine hydrochloride and pseudoephedrine hydrochloride tablet, film coated, extended release [package insert]. DailyMed.

                    View All References (3)

                    Naqvi, A., et al. (2024). Cetirizine. StatPearls.

                    Pfizer Labs. (2003). Zyrtec-D 12 Hour® (cetirizine hydrochloride 5 mg and pseudoephedrine hydrochloride 120 mg) extended release tablets for oral use.

                    U.S. Food and Drug Administration. (2024). Legal requirements for the sale and purchase of drug products containing pseudoephedrine, ephedrine, and phenylpropanolamine.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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