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Compare Zyrtec vs. Advil Allergy and Congestion

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Cetirizine (Zyrtec) and Advil Allergy and Congestion Relief (ibuprofen/phenylephrine/chlorpheniramine) are both used to treat allergy symptoms, but they have some key differences. Cetirizine is a second-generation antihistamine that primarily helps with symptoms like runny nose, itchy eyes, and sneezing. It is available in various forms, including tablets and liquids, and is typically taken once a day. On the other hand, Advil Allergy and Congestion Relief is a combination of three medications: an antihistamine (chlorpheniramine), a nonsteroidal anti-inflammatory drug (NSAID) ibuprofen, and a decongestant (phenylephrine). This combination addresses allergy symptoms, relieves pain, and reduces inflammation. But it's not the best choice for congestion because studies show oral phenylephrine doesn't work. Advil Allergy and Congestion Relief is taken every 4 hours and is not suitable for children under 12 years old. Additionally, it carries more risks, such as stomach bleeding and heart issues, especially if you have certain medical conditions or are pregnant. In contrast, cetirizine is considered safer for pregnant individuals and has fewer severe side effects.

  • Cetirizine (Zyrtec)
    Advil allergy and congestion relief
  • Cetirizine (Zyrtec)
    Advil allergy and congestion relief

  • Summary of Zyrtec vs. Advil Allergy and Congestion

    Summary for Antihistamine

    Cetirizine (Zyrtec) is an antihistamine. It's used for relief of allergy symptoms, such as runny nose or watery eyes, in adults and children. Cetirizine (Zyrtec) is also a safe option for people who are pregnant. This medication is available in different formulations, including tablets and liquid solutions. Typically, cetirizine (Zyrtec) is taken by mouth once per day. The most common side effect of cetirizine (Zyrtec) is sleepiness. But it's less likely to make you drowsy compared to some other antihistamines, such as diphenhydramine (Benadryl).

    Summary for Antihistamine / NSAID / Decongestant

    Advil Allergy and Congestion Relief is a combination of three medications, chlorpheniramine (antihistamine), ibuprofen (non-steroidal anti-inflammatory drug (NSAID)), and phenylephrine (decongestant). It's available over the counter (OTC) and used to treat symptoms from allergies and the common cold.

  • Indications of Zyrtec vs. Advil Allergy and Congestion

    Indications for
    •Short-term relief of allergy symptoms (sneezing, runny nose, itchy or watery eyes, itching of the nose or throat)
    •Relief of itchiness due to chronic (long-term) hives in children ages 6 months to under 6 years old - certain liquid solutions only
    Indications for
    •Short-term relief of symptoms from allergies and the common cold: runny nose, itchy or watery eyes, itchy nose or throat, sneezing, nasal congestion, sinus pressure, headache, minor aches and pains, fever
    •Lowers swelling in the sinuses around the nose
    •Restores breathing through the nose

  • Pros and Cons of Zyrtec vs. Advil Allergy and Congestion

    Pros and Const for Antihistamine
    Pros
    •First-choice option for relieving allergy symptoms
    •Taken once per day
    •Available in several formulations (e.g., pills, chewable tablets, orally disintegrating tablets, liquids)
    •Safe to take while pregnant
    Cons
    •Can cause you to feel sleepy
    •Higher risk of side effects in people with liver or kidney problems
    •Pills can't be used in children younger than 6 years.
    Pros and Const for Antihistamine / NSAID / Decongestant
    Pros
    •Can treat a wide variety of allergy and common cold symptoms
    •More convenient to take three medications in one pill
    •Available over the counter
    Cons
    •Needs to be taken every 4 hours
    •More difficult to customize the dose since Advil Allergy and Congestion Relief is a combination of three medications
    •Can cause stomach bleeding or stomach ulcers
    •Can't be used in children younger than 12 years old, right before or after heart surgery, or with current or recent (within the last 14 days) use of monoamine oxidase inhibitors (MAOIs)

  • Common Side Effects of Zyrtec vs. Advil Allergy and Congestion

    Common Side Effects for

    People 12 years of age and older:

    •Sleepiness (14%)
    •Tiredness (6%)
    •Dry mouth (5%)

    Children age 6 to under 12 years:

    •Headache (11-14%)
    •Sore throat (3-6%)
    •Stomach pain (4-6%)
    •Cough (3-4%)
    •Sleepiness (2-4%)
    Common Side Effects for
    •Dizziness
    •Sleepiness
    •Constipation
    •Upset stomach
    •Heartburn
    •Nausea
    •Headache
    •Dry mouth

  • Warnings of Zyrtec vs. Advil Allergy and Congestion

    Common Side Effects for
    •Sleepiness
    •Accidentally taking too much medication
    Common Side Effects for
    •Stomach bleeding
    •Heart attack and stroke
    •Severe allergic reactions
    •Worsening of medical conditions
    •Accidental overdose
    •Potential harm to unborn baby

  • Prices with our coupons for Zyrtec vs. Advil Allergy and Congestion

    Learn more about Cetirizine
    Learn more about Advil allergy and congestion relief

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