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Compare Zyrtec vs. Allegra-D

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Cetirizine (Zyrtec) and Allegra-D (fexofenadine/pseudoephedrine) are both used to treat allergy symptoms, but they have some key differences. Cetirizine is a second-generation antihistamine that helps relieve symptoms like runny nose and itchy eyes. It is available in various forms, including tablets and liquids, and can be taken once a day. Cetirizine is less likely to cause drowsiness compared to first-generation antihistamines like diphenhydramine (Benadryl). On the other hand, Allegra-D combines fexofenadine, an antihistamine, with pseudoephedrine, a decongestant. This combination helps with both allergies and congestion but can cause trouble sleeping and anxiety. Allegra-D is available as a 12-hour or 24-hour tablet and must be taken on an empty stomach. Cetirizine can be taken with or without food. Unlike cetirizine, Allegra-D requires you to show a photo ID to purchase it due to its pseudoephedrine content, which can be used to make illegal drugs. Additionally, Allegra-D is not recommended for people with high blood pressure or heart problems.

drug combination

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  • Cetirizine (Zyrtec)
    Allegra-d (fexofenadine / pseudoephedrine)
  • Cetirizine (Zyrtec)
    Allegra-d (fexofenadine / pseudoephedrine)

  • Summary of Zyrtec vs. Allegra-D

    Summary for Antihistamine

    Cetirizine (Zyrtec) is an antihistamine. It's used for relief of allergy symptoms, such as runny nose or watery eyes, in adults and children. Cetirizine (Zyrtec) is also a safe option for people who are pregnant. This medication is available in different formulations, including tablets and liquid solutions. Typically, cetirizine (Zyrtec) is taken by mouth once per day. The most common side effect of cetirizine (Zyrtec) is sleepiness. But it's less likely to make you drowsy compared to some other antihistamines, such as diphenhydramine (Benadryl).

    Summary for Antihistamine / Decongestant

    Allegra-D is a combination of two medications: pseudoephedrine (a decongestant) and fexofenadine (an antihistamine). It's taken by people ages 12 years and older to relieve allergy symptoms, like sinus congestion and runny nose. Allegra-D (fexofenadine / pseudoephedrine) is taken by mouth, either every 12 hours or every 24 hours, depending on the formulation (Allegra-D 12-hour or Allegra-D 24-hour. Some common side effects include headache and trouble sleeping. This medication is available as both brand name and generics.

  • Indications of Zyrtec vs. Allegra-D

    Indications for
    •Short-term relief of allergy symptoms (sneezing, runny nose, itchy or watery eyes, itching of the nose or throat)
    •Relief of itchiness due to chronic (long-term) hives in children ages 6 months to under 6 years old - certain liquid solutions only
    Indications for

    Short-term relief of allergy symptoms in adults and children ages 12 years and older:

    •Itchy nose or throat
    •Sneezing
    •Itchy or watery eyes
    •Runny or stuffy nose
    •Sinus congestion or pressure

  • Pros and Cons of Zyrtec vs. Allegra-D

    Pros and Const for Antihistamine
    Pros
    •First-choice option for relieving allergy symptoms
    •Taken once per day
    •Available in several formulations (e.g., pills, chewable tablets, orally disintegrating tablets, liquids)
    •Safe to take while pregnant
    Cons
    •Can cause you to feel sleepy
    •Higher risk of side effects in people with liver or kidney problems
    •Pills can't be used in children younger than 6 years.
    Pros and Const for Antihistamine / Decongestant
    Pros
    •Starts working within an hour
    •Easier to take a combination pill instead of two separate pills
    •Available as a once-daily tablet
    •Available over the counter (behind the counter)
    Cons
    •Tablets can't be crushed or chewed and there isn't a liquid version available
    •Best to take on empty stomach
    •Not for children younger than 12 years old
    •Not a good option for people with kidney or heart problems

  • Common Side Effects of Zyrtec vs. Allegra-D

    Common Side Effects for

    People 12 years of age and older:

    •Sleepiness (14%)
    •Tiredness (6%)
    •Dry mouth (5%)

    Children age 6 to under 12 years:

    •Headache (11-14%)
    •Sore throat (3-6%)
    •Stomach pain (4-6%)
    •Cough (3-4%)
    •Sleepiness (2-4%)
    Common Side Effects for
    •Trouble sleeping (11%)
    •Headache (9%)
    •Nausea (6%)

  • Warnings of Zyrtec vs. Allegra-D

    Common Side Effects for
    •Sleepiness
    •Accidentally taking too much medication
    Common Side Effects for
    •Fast heart rate and high blood pressure
    •Worsening of certain medical conditions
    •Accidentally taking too much medication

  • Prices with our coupons for Zyrtec vs. Allegra-D

    Learn more about Cetirizine
    Learn more about Allegra-d

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