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Compare Benadryl vs. Atarax

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Diphenhydramine (Benadryl) and hydroxyzine (Vistaril) are both antihistamines, but they have different uses and availability. Diphenhydramine is available over-the-counter and is commonly used to treat allergies, itching, and common cold symptoms. In contrast, hydroxyzine is a prescription-only medication used to relieve itching from allergies and sometimes for anxiety. While both medications can cause drowsiness, diphenhydramine is often used as a sleep aid, whereas hydroxyzine's drowsiness effect usually lessens over time. Hydroxyzine can also affect heart rhythm and isn't recommended during pregnancy, while diphenhydramine is considered safe for short-term use during pregnancy. Additionally, hydroxyzine can be used in children younger than 6 years old, whereas diphenhydramine should not be used for trouble sleeping in children under 12 years old.

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