Olopatadine vs. Allegra for Allergic Rhinitis: Important Differences and Potential Risks.

Key takeaways

Olopatadine (Pataday) and Fexofenadine (Allegra) are both antihistamines used to treat allergy symptoms, but they have some key differences. Olopatadine is an eye drop used to relieve eye itching and redness from allergies, while Fexofenadine is taken orally to treat general allergy symptoms and hives. Olopatadine is available in different strengths and can be used once or twice daily, depending on the formulation. In contrast, Fexofenadine comes in various forms, including tablets, fast-melting tablets, and liquid, and is typically taken once or twice a day. Olopatadine works quickly, within minutes, and is suitable for children over 2 years old. Fexofenadine starts working in about 2 hours and once-daily formulations are not recommended for children under 12 years old. Additionally, Olopatadine can cause blurry vision and dry eye, while Fexofenadine may cause headaches and dry mouth. Both medications are available over the counter (OTC).

Olopatadine

(Pataday)

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Fexofenadine

(Allegra)

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Summary for Olopatadine

Over-the-counter

Olopatadine (Pataday) is an over-the-counter (OTC) allergy eye drop for adults and children 2 years and up. It works as an antihistamine to help relieve itchy and red eyes from allergies. There are 3 types of olopatadine eye drops (Pataday). There's a lower-strength version that's used twice a day. Regular-strength and extra-strength versions that are used once a day are also available. Some side effects include blurry vision and dry eye.

Indications for Olopatadine

Temporary relief of allergy eye symptoms, such as itchy and red eyes

Pros and Cons for Olopatadine

Pros

Works within minutes to help relieve itchy and red eyes from allergies
Safe for children over 2 years old
Available over the counter

Cons

Not for irritation caused by eye infections, contact lenses, or dry eye
Contains preservatives, which can cause eye irritation
Must take out contact lenses first before using

Common Side Effects for Olopatadine

Blurry vision
Burning or stinging in the eye
Feeling like something is in the eye
Common cold symptoms
Sore throat

Warnings for Olopatadine

For use in the eyes only
Remove contact lenses before use

Summary for Allegra

Over-the-counter

Fexofenadine (Allegra) is an antihistamine. It's used to ease symptoms of allergy and hives in adults and children. Fexofenadine (Allegra) can be found over the counter as a tablet, fast-melting tablet, and liquid. This medication is taken once or twice per day, depending on the formulation. Fexofenadine (Allegra) starts to work in about 2 hours and its effects can last up to 24 hours. Fexofenadine (Allegra) doesn't make you as drowsy compared to some other antihistamines, such as diphenhydramine (Benadryl). Other possible side effects of fexofenadine (Allegra) include headache and dry mouth.

Indications for Allegra

Short-term relief of allergy symptoms (sneezing, runny nose, itchy or watery eyes, itchy nose or throat)
Treatment of hives

Pros and Cons for Allegra

Pros

First-choice option for relieving allergy symptoms
Some products can also be used to relieve itchiness from hives.
Available as 12-hour and 24-hour tablets, as well as a liquid and quick-dissolving tablets for those who have a hard time swallowing pills
All formulations available over the counter

Cons

Liquid form might not be the best choice for people on a low-salt diet because it contains sodium
Once-daily formulations not recommended for children younger than 12 years old
Might have a higher risk of side effects if you have liver or kidney problems
Can cause headache