Key takeaways
Astepro Allergy (azelastine) and Afrin (oxymetazoline) are both nasal sprays used to relieve nasal symptoms, but they belong to different medication classes. Astepro Allergy (azelastine) is an antihistamine that treats allergy symptoms like a stuffy nose, sneezing, and runny nose by blocking histamine. Afrin (oxymetazoline), on the other hand, is an alpha-1 receptor agonist that works by tightening blood vessels in the nose to relieve congestion. Astepro Allergy (azelastine) can be used daily and is available over-the-counter for adults and children 6 years and older, while Afrin (oxymetazoline) should not be used for more than 3 days in a row to avoid rebound congestion. Astepro Allergy (azelastine) may cause drowsiness and a bitter taste, whereas Afrin (oxymetazoline) can cause burning or stinging in the nose. Afrin (oxymetazoline) is not recommended for people with high blood pressure, while Astepro Allergy (azelastine) does not have this restriction. Both medications are available over-the-counter, but they have different side effects and usage guidelines.
