Skip to main content

Compare
Elestat vs. Zyrtec

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Epinastine (Elestat) and cetirizine (Zyrtec) are both antihistamines used to treat allergy symptoms. Epinastine is specifically used as an eye drop to prevent eye itchiness from allergies, while cetirizine is taken orally to relieve a broader range of allergy symptoms, such as runny nose and itchy or watery eyes. Epinastine is available only by prescription and is applied directly to the eyes twice a day, whereas cetirizine can be purchased over-the-counter and is typically taken once a day. Epinastine works quickly, within about 5 minutes, and is suitable for children aged 2 years and older. Cetirizine, on the other hand, starts working in 20 to 60 minutes and is available in various forms, including tablets and liquids, for different age groups. Common side effects of epinastine include a burning feeling in the eye and eye redness, while cetirizine may cause sleepiness and dry mouth. Additionally, cetirizine should not be taken with other antihistamines like diphenhydramine (Benadryl) due to the risk of increased side effects.

Epinastine

 

Get free coupons

Cetirizine

(Zyrtec)

Get free coupons

Summary for Elestat

Prescription only

Epinastine hydrochloride is an antihistamine eye drop medication. It's used to prevent eye itchiness that's related to allergies. The eye drops are available by prescription for adults and children 2 years of age and older. The medication is placed directly into the eyes twice a day. Side effects include a burning feeling in the eye and eye redness.

Indications for Elestat

Pros and Cons for Elestat

Pros

  • Works within 5 minutes
  • Applied directly to the eye(s), so there aren't many side effects
  • Can be used by children ages 2 years and older

Cons

  • Must use twice a day
  • Requires a prescription from a healthcare professional
  • Only approved for preventing eye itchiness from allergies

Common Side Effects for Elestat

  • Burning feeling in the eye (up to 10%)
  • Eye redness (up to 10%)
  • Small bumps around the eye (up to 10%)
  • Itchy eye (up to 10%)
  • Upper respiratory tract infection (e.g., common cold; 10%))

Warnings for Elestat

  • For use in the eye only
  • Risk for bacterial infections in the eye if you use contaminated medication
  • Don't use while wearing contact lenses

Summary for Zyrtec

Prescription or over-the-counter

Cetirizine (Zyrtec) is an antihistamine. It's used for relief of allergy symptoms, such as runny nose or watery eyes, in adults and children. Cetirizine (Zyrtec) is also a safe option for people who are pregnant. This medication is available in different formulations, including tablets and liquid solutions. Typically, cetirizine (Zyrtec) is taken by mouth once per day. The most common side effect of cetirizine (Zyrtec) is sleepiness. But it's less likely to make you drowsy compared to some other antihistamines, such as diphenhydramine (Benadryl).

Indications for Zyrtec

  • Short-term relief of allergy symptoms (sneezing, runny nose, itchy or watery eyes, itching of the nose or throat)
  • Relief of itchiness due to chronic (long-term) hives in children ages 6 months to under 6 years old - certain liquid solutions only

Pros and Cons for Zyrtec

Pros

  • First-choice option for relieving allergy symptoms
  • Taken once per day
  • Available in several formulations (e.g., pills, chewable tablets, orally disintegrating tablets, liquids)
  • Safe to take while pregnant

Cons

  • Can cause you to feel sleepy
  • Higher risk of side effects in people with liver or kidney problems
  • Pills can't be used in children younger than 6 years.

Common Side Effects for Zyrtec

People 12 years of age and older:

  • Sleepiness (14%)
  • Tiredness (6%)
  • Dry mouth (5%)

Children age 6 to under 12 years:

  • Headache (11-14%)
  • Sore throat (3-6%)
  • Stomach pain (4-6%)
  • Cough (3-4%)
  • Sleepiness (2-4%)

Warnings for Zyrtec

  • Sleepiness
  • Accidentally taking too much medication

Prices with our coupons for Elestat vs. Zyrtec

Price Card Drug Icon
Epinastine1 eye dropper / 5ml of 0.05%
$30.93$132.99
Get free coupons
More Information
Price Card Drug Icon
Cetirizine90 tablets / 24 hour of 10mg
$9.11-
Get free coupons
More Information

Browse medications by letter

Show All

Browse prescription and over-the-counter medications from A to Z, compare drug prices, and start saving.