Key takeaways
Lastacaft (alcaftadine) and epinastine (Elestat) are both antihistamine eye drops used to treat red and itchy eyes caused by allergies, but they have some key differences. Lastacaft is available over-the-counter, while epinastine requires a prescription. You only need to use Lastacaft once a day, but epinastine needs to be applied twice a day. Lastacaft is only available as a brand medication, whereas epinastine is available in a more affordable generic form. Both medications can be used in children as young as 2 years old and should not be used to treat eye irritation caused by contact lenses. Common side effects for both include eye irritation and redness, but epinastine can also cause small bumps on the eyelid and cold or flu symptoms.
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