Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Lastacaft (alcaftadine) and ketorolac (Acular) are both eye drops, but they serve different purposes and belong to different drug classes. Lastacaft is an antihistamine and mast cell stabilizer used to treat eye itching and redness due to allergies. It is available over-the-counter and is typically used once daily. In contrast, Acular is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation after eye surgeries, and it can also help with allergy-related itchy eyes, though it is not the first choice for this condition. Acular requires a prescription and is usually used 2 to 4 times a day. Both medications are available brand and generic forms. Common side effects of Lastacaft include eye irritation and burning, whereas Acular can cause stinging, burning, and headache. Both medications require careful handling to avoid contamination and should not be used with contact lenses in place.
Lastacaft (alcaftadine)
Ketorolac eye drop
Lastacaft (alcaftadine)
Ketorolac eye drop
Summary of Lastacaft vs. Acular
Summary for Antihistamine
Lastacaft (alcaftadine) is a once-daily anti-allergy eye drop. It was previously available only by prescription, but you can now get it over the counter.
Summary for NSAID
Prescription only
Ketorolac eye drop is a non-steroidal anti-inflammatory drug (NSAID). It's used to treat inflammation and pain after corneal or cataract surgery. Ketorolac eye drop can also help with itchy eyes from allergies, but it's not a first-choice medication for this condition. Ketorolac eye drop can be used by adults and children and is typically instilled 2 to 4 times per day, depending on the medical condition. Some common side effects include stinging, burning, and irritation after putting the eye drops. Ketorolac eye drop is available as a generic and as brand name medications (Acular, Acular LS, and Acuvail).
Indications of Lastacaft vs. Acular
Indications for
•Eye itching or redness due to allergies (allergic conjunctivitis)
Indications for
•Relief of pain or inflammation after cornea refractive surgery in people ages 3 years and older - Ketorolac (Acular LS) 0.4% only
•Relief of pain or inflammation after cataract removal in people ages 2 years and older- Ketorolac (Acuvail) 0.45% and ketorolac (Acular) 0.5% only
•Itchy eyes due to allergies in people ages 2 years and older - Ketorolac (Acular) 0.5% only
Pros and Cons of Lastacaft vs. Acular
Pros and Const for Antihistamine
Pros
•Used just once daily
•Can be given to children as young as 2 years of age
•Doesn't leave weird aftertaste like the similar medication called Bepreve (bepotastine)
Cons
•Can cause eye pain and irritation
•Not for itching caused by infections or contact lenses
•Can be more expensive than many alternatives
Pros and Const for NSAID
Pros
•Works well for eye pain, inflammation, and itching
•Causes fewer serious side effects than oral ketorolac
•Both ketorolac 0.4% and 0.5% strengths are available as lower-cost generics.
•A possible option for children
Cons
•Can cause temporary stinging or burning after using
•Need to use 2 to 4 times a day
•Might not be safe if you're allergic to NSAIDs or aspirin
•Requires removal of soft contact lenses
Common Side Effects of Lastacaft vs. Acular
Common Side Effects for
•Eye irritation
•Burning and stinging in the eye
•Eye redness
•Eye itching
Common Side Effects for
•Temporary stinging or burning (up to 40%)
•Eye redness, swelling, or pain (up to 10%)
•Headache (up to 6%)
•Higher eye pressure after cataract surgery (up to 6%)
•Bleeding in the outermost membrane of the eye (up to 6%)