Key takeaways
Epinastine (Elestat) and fexofenadine (Allegra) are both antihistamines used to treat allergy symptoms. Epinastine is specifically used as an eye drop to prevent eye itchiness from allergies, while fexofenadine is taken orally to relieve general allergy symptoms and hives. Epinastine is available by prescription only and is applied directly to the eyes twice a day, whereas fexofenadine can be purchased over-the-counter in various forms, such as tablets and liquid, and is taken once or twice daily depending on the formulation. Epinastine works quickly, within 5 minutes, but its effects last about 8 hours, while fexofenadine takes about 2 hours to start working and can last up to 24 hours. Common side effects of epinastine include a burning feeling in the eye and eye redness, while fexofenadine may cause headaches and dry mouth. Additionally, fexofenadine should not be taken with fruit juices or certain antacids, as these can affect how well the medication is absorbed.
