Key takeaways
Cetirizine (Zyrtec) and fexofenadine (Allegra) are both second-generation antihistamines used to relieve allergy symptoms like runny nose and itchy eyes. They have several differences between them. Cetirizine can cause drowsiness, but it's less likely to do so compared to first-generation antihistamines like diphenhydramine (Benadryl). Fexofenadine is even less likely to cause drowsiness than cetirizine. Cetirizine is typically taken once a day, whereas fexofenadine can be taken once or twice a day depending on the formulation. Cetirizine starts working within 20 to 60 minutes, while fexofenadine takes about 2 hours to start working. Both medications come in various forms, but cetirizine offers chewable tablets.
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