Key takeaways
Ryaltris (olopatadine / mometasone) and azelastine are both nasal sprays used to treat nasal symptoms of allergies, such as a runny or stuffy nose. However, they have some different characteristics. Ryaltris is a combination of an antihistamine (olopatadine) and a corticosteroid (mometasone), while azelastine is solely an antihistamine. Ryaltris is FDA-approved for treating eye and nasal symptoms of seasonal allergies in people aged 12 and older, whereas azelastine can treat both seasonal and year-round nasal allergy symptoms, and even non-allergic nasal symptoms with its 0.1% spray, and can be used in children as young as 5 years of age. Ryaltris is available only as a brand-name prescription medication, while azelastine is available as a lower-cost generic prescription and over the counter in its 0.15% form. Ryaltris is typically dosed as two sprays in each nostril twice a day, while azelastine can be dosed once or twice a day depending on the dose and your age. Common side effects of Ryaltris include a bad taste in the mouth and nosebleeds, while azelastine may cause a bitter taste, headache, and sleepiness. Both medications can cause drowsiness, so you should avoid alcohol and be cautious with activities that require alertness.
