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Compare Ryaltris vs. Flonase

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ryaltris (olopatadine/mometasone) and Flonase (fluticasone) are both nasal sprays used to treat allergy symptoms like runny nose and sneezing. They both help with nasal symptoms, but they have some differences. Ryaltris is a combination of an antihistamine (olopatadine) and a corticosteroid (mometasone), while Flonase is a corticosteroid (fluticasone) only. Ryaltris is available by prescription only while Flonase can be bought over-the-counter. Ryaltris is typically used twice daily, while Flonase can be used once or twice daily. Ryaltris is approved for people ages 12 and older, whereas Flonase can be used in children as young as 2 years old, depending on the formulation. Ryaltris doesn't commonly cause side effects, but can cause a bad taste in the mouth and nosebleeds, while Flonase can cause headaches and sore throats. Ryaltris may interact with some medications, like clarithromycin, ritonavir, and itraconazole. Make sure your prescriber and pharmacist have a complete list of your medications.

  • Ryaltris (olopatadine / mometasone)
    Fluticasone nasal spray
  • Ryaltris (olopatadine / mometasone)
    Fluticasone nasal spray

  • Summary of Ryaltris vs. Flonase

    Summary for Antihistamine / Corticosteroid
    Prescription only

    Ryaltris is a combination of two medications: olopatadine (an antihistamine) and mometasone (a corticosteroid). It's a nasal spray used to treat eye and nasal symptoms of seasonal allergies (e.g., runny nose, stuffy nose, sneezing, itchy eyes) in people ages 12 and older. The dosage is 2 sprays in each nostril twice per day. Ryaltris (olopatadine / mometasone) doesn't have a generic version since it's only available as a brand-name medication. Side effects aren't common, but include a bad taste in the mouth and nosebleeds.

    Summary for Corticosteroid

    Fluticasone nasal spray is used to treat allergy symptoms, like runny nose and sneezing. Fluticasone nasal spray comes in brand and generic forms, and is available by a prescription or over-the-counter (OTC). Fluticasone nasal spray must be used daily in order for you to experience the maximum benefits. But if you're using OTC versions of this medication, don't use it for more than 6 months at a time (or 2 months at a time, for children) without first speaking to your provider.

  • Indications of Ryaltris vs. Flonase

    Indications for
    •Eye and nasal symptoms of seasonal allergies (e.g., runny nose, stuffy nose, sneezing, itchy eyes)
    Indications for

    Nasal symptoms from allergies, such as:

    •Congestion
    •Runny nose
    •Sneezing
    •Itchy nose
    •Itchy, watery eyes

  • Pros and Cons of Ryaltris vs. Flonase

    Pros and Const for Antihistamine / Corticosteroid
    Pros
    •Combines two first-choice medications into a single spray
    •Starts to work within 15 minutes
    •Less side effects than antihistamines and steroids taken by mouth
    Cons
    •Can cause nosebleeds and nasal irritation
    •Need to use twice per day
    •Available by prescription only
    Pros and Const for Corticosteroid
    Pros
    •Only has to be used once a day and can last up to 24 hours
    •Available OTC
    •Some formulations have generic versions
    •Can be used safely in children as young as 4 years old
    •Flonase Sensimist is a gentler version that can be used in children as young as 2 years old
    Cons
    •Not a good option if you have an injured nose or had recent nasal surgery
    •Can raise the risk of bleeding and fungal infections in the nose
    •Can slow down growth rate in children if used for longer than 2 months per year
    •Can raise the risk for certain eye problems

  • Common Side Effects of Ryaltris vs. Flonase

    Common Side Effects for
    •Altered taste (3%)
    •Nosebleed (1%)
    •Nasal discomfort (1%)
    Common Side Effects for
    •Headache (7-16%)
    •Sore throat (6-8%)
    •Nosebleeds (6-7%)
    •Asthma symptoms (3-7%)

  • Warnings of Ryaltris vs. Flonase

    Common Side Effects for
    •Nasal problems
    •Drowsiness
    •Eye and vision problems
    •Allergic reactions
    •Risk of infection
    •Altered stress hormone levels
    •Slowed growth in children
    Common Side Effects for
    •Nasal problems
    •Slowed growth rate in children
    •Eye problems
    •Higher risk of infections
    •Stress hormone problems (adrenal gland problems)
    •Serious allergic reactions

  • Prices with our coupons for Ryaltris vs. Flonase

    Learn more about Ryaltris
    Learn more about Fluticasone nasal spray

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