Key takeaways
Azelastine nasal spray and cetirizine (Zyrtec) are both antihistamines used to treat allergy symptoms like a runny nose and sneezing. However, they differ in several ways. Azelastine is a nasal spray, while cetirizine is taken orally in forms like tablets and liquids. Azelastine is available by prescription and over-the-counter, but only the 0.15% strength is available without a prescription. Cetirizine is available both over-the-counter and by prescription. Azelastine is typically used twice a day, whereas cetirizine is usually taken once a day. Common side effects of azelastine include a bitter taste and nasal discomfort, while cetirizine can cause sleepiness and dry mouth. Both medications can cause drowsiness, so you should avoid alcohol and be cautious when driving. Azelastine is not known to cause weight gain, but cetirizine is considered safe during pregnancy.
