Key takeaways
Nasonex (mometasone) and Afrin (oxymetazoline) are both nasal sprays, but they work differently and are used for different purposes. Nasonex is a corticosteroid that helps reduce inflammation and is used to treat allergy symptoms and nasal polyps. It can be used daily and is available both over-the-counter and by prescription. On the other hand, Afrin is an alpha-1 receptor agonist that works by tightening blood vessels in your nose to relieve congestion. It provides quick relief but should not be used for more than 3 days in a row to avoid rebound congestion. Nasonex can take 1 to 2 weeks to show full effects, while Afrin works within minutes and lasts up to 12 hours. Nasonex is safe for children as young as 2 years old (OTC version), whereas Afrin is only recommended for children 6 years and older. Both medications have side effects, but Nasonex can cause headaches and nosebleeds, while Afrin might cause burning or stinging in the nose.
