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Compare Nasonex vs. Afrin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Nasonex (mometasone) and Afrin (oxymetazoline) are both nasal sprays, but they work differently and are used for different purposes. Nasonex is a corticosteroid that helps reduce inflammation and is used to treat allergy symptoms and nasal polyps. It can be used daily and is available both over-the-counter and by prescription. On the other hand, Afrin is an alpha-1 receptor agonist that works by tightening blood vessels in your nose to relieve congestion. It provides quick relief but should not be used for more than 3 days in a row to avoid rebound congestion. Nasonex can take 1 to 2 weeks to show full effects, while Afrin works within minutes and lasts up to 12 hours. Nasonex is safe for children as young as 2 years old (OTC version), whereas Afrin is only recommended for children 6 years and older. Both medications have side effects, but Nasonex can cause headaches and nosebleeds, while Afrin might cause burning or stinging in the nose.

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