Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Dymista (azelastine/fluticasone) and azelastine nasal spray are both used to treat nasal allergy symptoms, but they have some key differences. Dymista is a combination of two medications: azelastine, an antihistamine, and fluticasone, a corticosteroid. This combination helps to block histamine and reduce inflammation, providing relief from symptoms like sneezing, runny nose, and itching. On the other hand, azelastine nasal spray contains only azelastine, which solely blocks histamine to relieve similar symptoms. Dymista is typically used when nasal steroid medications alone are not effective, while azelastine can be used for both seasonal and year-round allergies, as well as non-allergic nasal symptoms. Dymista is available only by prescription and must be used twice daily, whereas azelastine is available in both prescription and over-the-counter forms, with dosing that can vary. Additionally, Dymista may cause drowsiness and has a risk of stunting growth in children, while azelastine can cause a bitter taste and nasal discomfort. Both medications need to be primed before use and can cause sleepiness, so you should avoid activities that require alertness until you know how they affect you.
Dymista (azelastine / fluticasone)
Azelastine nasal spray
Dymista (azelastine / fluticasone)
Azelastine nasal spray
Summary of Dymista vs. Astelin
Summary for Antihistamine / Corticosteroid
Prescription only
Dymista is a combination nasal spray containing azelastine (an antihistamine) and fluticasone (a corticosteroid). It's used by people ages 6 years and older to treat nasal allergy symptoms, such as runny, stuffy, or itchy nose. The typical dose is to spray one spray into each nostril twice per day. Side effects aren't common, but include headache and a bad taste in the mouth. Dymista (azelastine / fluticasone) is available as both brand-name and generic medications.
Summary for Antihistamine
Prescription only
Azelastine nasal spray is an antihistamine that treats allergies and nasal symptoms, such as runny or stuffy nose. The 0.1% and 0.15% strengths of the azelastine nasal spray are available with a prescription for adults and children. It's sprayed into the nostrils typically twice a day. Prescription azelastine nasal spray is a lower-cost generic. Possible side effects include a bitter taste in the mouth and nasal discomfort.
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Note: Azelastine 0.15% nasal spray is also available over the counter under the brand name Astepro Allergy.
Indications of Dymista vs. Astelin
Indications for
•Nasal allergy symptoms (e.g., runny, stuffy, or itchy nose, sneezing, itchy or watery eyes)
Indications for
•Seasonal allergy symptoms related to the nose
•Year-round allergy symptoms related to the nose - azelastine 0.15% spray only