Key takeaways
Zyrtec (cetirizine) and Benadryl (diphenhydramine) are over-the-counter antihistamines. They both treat symptoms of seasonal allergies, but there are several differences between them. Zyrtec is usually taken once daily. It lasts longer than Benadryl, which is typically taken every 4 to 6 hours. Benadryl is also taken for sleep problems (insomnia) in some cases because it’s known to cause drowsiness. However, for this reason it’s best to avoid it if you’re over 65 years old. Even though drowsiness is possible with Zyretc, it’s less likely.
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