Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Fexofenadine (Allegra) and Allegra-D (fexofenadine/pseudoephedrine) are both used to treat allergy symptoms, but they have some key differences. Fexofenadine (Allegra) is a second-generation antihistamine that helps relieve symptoms like sneezing, runny nose, and itchy eyes. It is available over-the-counter in various forms, including tablets, liquid, and fast-melting tablets. Allegra-D, on the other hand, is a combination of fexofenadine and pseudoephedrine, which adds a decongestant to help clear your sinuses. This makes Allegra-D effective for both allergies and congestion. However, Allegra-D can cause more side effects like trouble sleeping and anxiety due to the pseudoephedrine. Allegra-D can also raise your blood pressure so it may not be the best option if you have hypertension (high blood pressure). Additionally, Allegra-D is found behind the pharmacy counter because the pseudoephedrine component carries a potential for abuse. Both medications should be taken on an empty stomach and not with fruit juices, but Allegra-D should be swallowed whole without cutting or crushing the tablets.
Fexofenadine (Allegra) is an antihistamine. It's used to ease symptoms of allergy and hives in adults and children. Fexofenadine (Allegra) can be found over the counter as a tablet, fast-melting tablet, and liquid. This medication is taken once or twice per day, depending on the formulation. Fexofenadine (Allegra) starts to work in about 2 hours and its effects can last up to 24 hours. Fexofenadine (Allegra) doesn't make you as drowsy compared to some other antihistamines, such as diphenhydramine (Benadryl). Other possible side effects of fexofenadine (Allegra) include headache and dry mouth.
Summary for Antihistamine / Decongestant
Allegra-D is a combination of two medications: pseudoephedrine (a decongestant) and fexofenadine (an antihistamine). It's taken by people ages 12 years and older to relieve allergy symptoms, like sinus congestion and runny nose. Allegra-D (fexofenadine / pseudoephedrine) is taken by mouth, either every 12 hours or every 24 hours, depending on the formulation (Allegra-D 12-hour or Allegra-D 24-hour. Some common side effects include headache and trouble sleeping. This medication is available as both brand name and generics.
Indications of Allegra vs. Allegra-D
Indications for
•Short-term relief of allergy symptoms (sneezing, runny nose, itchy or watery eyes, itchy nose or throat)