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Compare Allegra-D vs. Mucinex D

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Allegra-D (fexofenadine/pseudoephedrine) and Mucinex D (guaifenesin/pseudoephedrine) are both over-the-counter medications that contain pseudoephedrine, a decongestant used to relieve sinus congestion and pressure. However, they belong to different medication classes and treat different symptoms. Allegra-D combines an antihistamine (fexofenadine) with pseudoephedrine to relieve allergy symptoms like itchy or watery eyes, sneezing, and runny or stuffy nose. Mucinex D, on the other hand, combines an expectorant (guaifenesin) with pseudoephedrine to help with chest congestion and a wet cough, in addition to nasal congestion. Allegra-D is available in 12-hour and 24-hour formulations, while Mucinex D is taken every 12 hours. Both medications can cause trouble sleeping and headaches, but Allegra-D may also cause anxiety and high blood pressure, while Mucinex D can lead to dry mouth and confusion. It's important to avoid taking either medication with monoamine oxidase inhibitors (MAOIs) and to consult with a healthcare provider if you have certain medical conditions like heart disease or high blood pressure.

  • Allegra-d (fexofenadine / pseudoephedrine)
    Mucinex d (guaifenesin / pseudoephedrine)
  • Allegra-d (fexofenadine / pseudoephedrine)
    Mucinex d (guaifenesin / pseudoephedrine)

  • Summary of Allegra-D vs. Mucinex D

    Summary for Antihistamine / Decongestant

    Allegra-D is a combination of two medications: pseudoephedrine (a decongestant) and fexofenadine (an antihistamine). It's taken by people ages 12 years and older to relieve allergy symptoms, like sinus congestion and runny nose. Allegra-D (fexofenadine / pseudoephedrine) is taken by mouth, either every 12 hours or every 24 hours, depending on the formulation (Allegra-D 12-hour or Allegra-D 24-hour. Some common side effects include headache and trouble sleeping. This medication is available as both brand name and generics.

    Summary for Expectorant / Decongestant

    Mucinex D is a combination medication containing two active ingredients: guaifenesin (an expectorant) and pseudoephedrine (a decongestant). It's used to help temporarily relieve stuffy nose, chest congestion, and sinus pressure. This medication can be used for people 12 years of age and older. It's an extended-release tablet that's taken by mouth every 12 hours and is also available as a lower-cost generic. Side effects can include trouble sleeping and headache.

  • Indications of Allegra-D vs. Mucinex D

    Indications for

    Short-term relief of allergy symptoms in adults and children ages 12 years and older:

    •Itchy nose or throat
    •Sneezing
    •Itchy or watery eyes
    •Runny or stuffy nose
    •Sinus congestion or pressure
    Indications for
    •Short-term relief of stuffy nose due to allergies or the common cold
    •Loosens mucus to ease chest congestion
    •Sinus congestion and pressure

  • Pros and Cons of Allegra-D vs. Mucinex D

    Pros and Const for Antihistamine / Decongestant
    Pros
    •Starts working within an hour
    •Easier to take a combination pill instead of two separate pills
    •Available as a once-daily tablet
    •Available over the counter (behind the counter)
    Cons
    •Tablets can't be crushed or chewed and there isn't a liquid version available
    •Best to take on empty stomach
    •Not for children younger than 12 years old
    •Not a good option for people with kidney or heart problems
    Pros and Const for Expectorant / Decongestant
    Pros
    •Helps with stuffy nose, chest and sinus congestion, and wet cough
    •Combines two medications in a single product for convenience
    •Available over the counter without a prescription (in most states)
    •Doesn't cause drowsiness or sleepiness
    Cons
    •More difficult to customize the dose since it's a fixed combination of two medications
    •Only available as an extended-release tablet, which can't be cut or crushed
    •Might not be the best choice for people with certain medical conditions, such as high blood pressure
    •Not the best choice if you're pregnant or breastfeeding

  • Common Side Effects of Allegra-D vs. Mucinex D

    Common Side Effects for
    •Trouble sleeping (11%)
    •Headache (9%)
    •Nausea (6%)
    Common Side Effects for
    •Trouble sleeping
    •Headache
    •Anxiety
    •Dry mouth

  • Warnings of Allegra-D vs. Mucinex D

    Common Side Effects for
    •Fast heart rate and high blood pressure
    •Worsening of certain medical conditions
    •Accidentally taking too much medication
    Common Side Effects for
    •Worsening of certain medical conditions
    •Accidentally taking too much medication

  • Prices with our coupons for Allegra-D vs. Mucinex D

    Learn more about Allegra-d
    Learn more about Mucinex d

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