Key takeaways
Diphenhydramine (Benadryl) and acetaminophen/dextromethorphan/phenylephrine (Dayquil Cold and Flu) are both over-the-counter medications that can be used to treat symptoms of the common cold. However, they belong to different medication classes and have important differences. Diphenhydramine is an antihistamine that helps with allergies, cold symptoms, and can be used as an occasional sleep aid due to its sedative effects. On the other hand, Dayquil Cold and Flu is a combination medication that includes an analgesic (acetaminophen), a cough suppressant (dextromethorphan), and a decongestant (phenylephrine) to relieve pain, cough, and nasal congestion. Diphenhydramine is available in various forms like tablets and liquids, while Dayquil is available as pills and liquid. Diphenhydramine can cause drowsiness, dizziness, and dry mouth, whereas Dayquil may cause stomach upset and nervousness. You should avoid alcohol with both medications and avoid acetaminophen-containing products with Dayquil Cold and Flu, to avoid getting too much acetaminophen.
