Key takeaways
Alcaftadine (Lastacaft) and bepotastine (Bepreve) are both antihistamine eye drops used to treat itchy eyes caused by allergies. They work by blocking histamine, a chemical that causes allergy symptoms. However, there are several differences between the two medications. Alcaftadine is available over-the-counter and is used once daily, while bepotastine requires a prescription and is used twice a day. Alcaftadine is only available as a brand-name medication, whereas bepotastine has a generic version. Common side effects of alcaftadine include eye irritation and redness, while bepotastine can cause an unpleasant taste in the mouth. Alcaftadine is noted for not leaving a weird aftertaste like bepotastine.. Both medications require you to remove contact lenses before use.
