Compare Zyrtec-D vs. Acetaminophen / dextromethorphan / doxylamine / phenylephrine

Zyrtec-D (cetirizine / pseudoephedrine) and Tylenol Cold + Flu + Cough Night (acetaminophen / dextromethorphan / doxylamine / phenylephrine) are both over-the-counter medications used to relieve symptoms of allergies, colds, and the flu. They both contain a decongestant to help with stuffy noses, but they are different in many ways. Zyrtec-D is a combination of an antihistamine (cetirizine) and a decongestant (pseudoephedrine) and is specifically used for allergy symptoms like runny nose and nasal congestion. The usual dosage is one tablet by mouth every 12 hours. On the other hand, Tylenol Cold + Flu + Cough Night combines four medications: a pain and fever medication (acetaminophen), a cough suppressant (dextromethorphan), an antihistamine (doxylamine), and a decongestant (phenylephrine). It's used for a wider range of cold and flu symptoms, including cough, sore throat, and fever. It comes as a liquid and is taken every 4 hours. Zyrtec-D can cause trouble sleeping, while Tylenol Cold + Flu + Cough Night may make you sleepy. Both medications have potential interactions with other medications, so check with your prescriber before taking either one.