provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Loratadine / Pseudoephedrine Coupon - Loratadine / Pseudoephedrine 24 hour tablet

loratadine / pseudoephedrine

Generic Claritin-D
Used for Nasal Congestion, Allergic Rhinitis
Used for Nasal Congestion, Allergic Rhinitis

Claritin-D (loratadine / pseudoephedrine) is an over-the-counter medication that's used to relieve allergies and congestion. It's available as a 24-hour tablet that's taken once per day and a 12-hour tablet that's taken twice per day. Possible side effects include headache, dry mouth, drowsiness, and difficulty sleeping. There are lower-cost generic and brand versions of the medication available. You can find Claritin-D (loratadine / pseudoephedrine) at the pharmacy counter (or behind the counter).

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Allison Gourley, PharmD
Last reviewed on June 28, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Claritin-D (loratadine / pseudoephedrine)?

What is Claritin-D (loratadine / pseudoephedrine) used for?

Short-term relief of allergy symptoms:

  • Runny nose

  • Itchy nose or throat

  • Itchy or watery eyes

  • Stuffy nose

  • Nasal congestion

  • Sinus congestion or pressure

How Claritin-D (loratadine / pseudoephedrine) works

Claritin-D (loratadine / pseudoephedrine) is a combination of two medications that work together to relieve allergy symptoms.

Are you looking for information on loratadine (Claritin) or pseudoephedrine (Sudafed) instead?
When does Claritin-D (loratadine / pseudoephedrine) start working?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsClaritin-D 12 Hour, Claritin-D 24 Hour, Alavert D-12 hour
Drug ClassAntihistamine / Decongestant
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityOver-the-counter
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$44.80(save 69.62%)
GoodRx discount
$13.61
See prices
basics-icon

What are the side effects of Claritin-D (loratadine / pseudoephedrine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Dry mouth
  • Sore throat
  • Drowsiness
  • Nervousness
  • Trouble sleeping

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Signs of an overdose: seizures, hallucinations, loss of consciousness, fast heartbeat, flushing, extreme sleepiness, changes in vision, irritability in children
  • High blood pressure or fast heart rate: chest pain, blurry vision, headache, fatigue
When do Claritin-D (loratadine / pseudoephedrine) possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Feeling nervous
Trouble sleeping

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart palpitations—rapid, pounding, or irregular heartbeat
  • Increase in blood pressure

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Claritin-D (loratadine / pseudoephedrine)

thumbs-up

Pros

Easier to take a combination pill instead of two separate pills for congestion and other allergy symptoms

Available as a once-daily tablet

Available over the counter

thumbs-down

Cons

More difficult to customize the dose since Claritin-D (loratadine / pseudoephedrine) is a combination of two medications

Not the best choice for people who have difficulty swallowing tablets (can't crush the tablets and no available liquid form available)

Can't be used in children younger than 12 years

pharmacist-tips

Pharmacist tips for Claritin-D (loratadine / pseudoephedrine)

pharmacist

  • You can take Claritin-D (loratadine / pseudoephedrine) with or without food. If it's hurting your stomach, try taking it with food to help.

    • Claritin-D (loratadine / pseudoephedrine) can raise your blood pressure. If you have heart problems or high blood pressure, ask your provider if it's safe for you to take Claritin-D (loratadine / pseudoephedrine).

      • It's possible for Claritin-D (loratadine / pseudoephedrine) to either make you sleepy or energetic. You can take Claritin-D (loratadine / pseudoephedrine) any time of the day, so take it at a time based on how it affects your ability to sleep.

        • Avoid drinking alcohol while taking Claritin-D (loratadine / pseudoephedrine) because this combination raises your risk of sleepiness and dizziness.

          • It's best to avoid or limit caffeine when you need to take Claritin-D (loratadine / pseudoephedrine). This combination can raise your risk for side effects like fast heart rate, high blood pressure, and difficulty sleeping.

            • Check with your provider or pharmacist first before starting any new medications while you're taking Claritin-D (loratadine / pseudoephedrine). They can check for harmful interactions. Just like Claritin-D (loratadine / pseudoephedrine), many other OTC allergy, cold, and flu medications can contain an antihistamine or decongestant. Taking too many decongestant or antihistamine medications at the same time can raise your risk of overdose and severe side effects, which can be life-threatening. This includes very high blood pressure, fast heart rate, seizures, and hallucinations (seeing things that aren't real).

              • Stop using Claritin-D (loratadine / pseudoephedrine) and contact your provider if you get nervous, dizzy, or can't sleep. Also stop using the medication and let your provider know if your symptoms don't get better within 7 days of starting Claritin-D (loratadine / pseudoephedrine) or if you develop a fever. These might be signs of another medication condition that's going on.

                faqs

                Frequently asked questions about Claritin-D (loratadine / pseudoephedrine)

                Does Claritin-D (loratadine / pseudoephedrine) make you drowsy?
                While uncommon, it's possible for Claritin-D (loratadine / pseudoephedrine) to make you drowsy (sleepy). A study showed that 6% of people taking the 24-hour tablet of Claritin-D (loratadine / pseudoephedrine) once daily felt drowsy, sleepy, or sluggish. In general, Claritin-D (loratadine / pseudoephedrine) is less likely to cause drowsiness than other antihistamines like diphenhydramine (Benadryl).
                What should I not take with Claritin-D (loratadine / pseudoephedrine)?
                Don't take other medications that have an antihistamine or decongestant (e.g., pseudoephedrine, phenylephrine). Claritin-D (loratadine / pseudoephedrine) already contains an antihistamine and a decongestant. Using multiple products that contain these types of medications can raise your risk for overdose and side effects. Also talk with your provider first before taking Claritin-D (loratadine / pseudoephedrine) with medications that have stimulant-like effects because this combination can raise your risk for dangerously high blood pressure. Since it's possible for Claritin-D (loratadine / pseudoephedrine) to make you feel drowsy, consult with a provider if you need to take medications that can raise your risk of drowsiness even more (e.g., opioids, sleep medications). If you're not sure whether you're taking a medication that interacts with Claritin-D (loratadine / pseudoephedrine), ask your provider or pharmacist.
                Is Claritin-D (loratadine / pseudoephedrine) over the counter, and where do I find it in the pharmacy?
                Yes, Claritin-D (loratadine / pseudoephedrine) is an over-the-counter medication that you can find at local pharmacies. But it's actually located behind the counter, which means that you'll need to go to the pharmacy counter to purchase it. You'll be asked to present photo identification and sign when you buy it. This is required because Claritin-D (loratadine / pseudoephedrine) can potentially be misused. Ask your pharmacist to help you locate Claritin-D (loratadine / pseudoephedrine) in the pharmacy.
                What's the difference between Claritin and Claritin-D?
                Claritin is the brand name for loratadine, an antihistamine that treats allergy symptoms like itchy or watery eyes, runny nose, and sneezing. Claritin-D 24-Hour and Claritin-D 12-Hour are brand names for tablets with both loratadine and pseudoephedrine. Because it contains pseudoephedrine (a decongestant), Claritin-D is more useful than Claritin for people who also have nasal or sinus congestion in addition to itchy or watery eyes, runny nose, and sneezing.
                Can you take Claritin-D (loratadine / pseudoephedrine) while pregnant or breastfeeding?
                If you're pregnant, thinking of getting pregnant, or breastfeeding, don't take Claritin-D (loratadine / pseudoephedrine) until you've talked to your provider first. This medication contains pseudoephedrine. The safety of pseudoephedrine during pregnancy isn't completely clear because of inconsistent results from limited data. Your provider will probably recommend that you avoid using Claritin-D (loratadine / pseudoephedrine) at least during the first 3 months of pregnancy because of the potential risk of harm to babies. Additionally, pseudoephedrine can potentially dry up your breast milk production and might cause your baby to be irritable. For these reasons, it's a good idea to discuss the risks and benefits of Claritin-D (loratadine / pseudoephedrine) with your provider first.
                How long is it safe to take Claritin-D (loratadine / pseudoephedrine)?
                Don't take Claritin-D (loratadine / pseudoephedrine) for longer than 7 days. If your symptoms haven't gotten better after 7 days of using the medication or if you develop a fever, you should stop using Claritin-D (loratadine / pseudoephedrine). Contact your provider because these could be signs of a more serious medical problem. They can make sure you get appropriate treatment.
                Can you take Claritin-D (loratadine / pseudoephedrine) and Mucinex together?
                It depends on which Mucinex product you choose to use. Mucinex is a brand that makes multiple products to treat cold and flu symptoms. Some of these products are single-ingredient medications, and others are combination products. Depending on the product, Mucinex can contain acetaminophen for pain, tripolidine (an antihistamine) for cold symptoms, and phenylephrine (a decongestant). It's not recommended to take a Mucinex product with Claritin-D (loratadine / pseudoephedrine) if that product has phenylephrine or triprolidine. Claritin-D (loratadine / pseudoephedrine) already has an antihistamine (loratadine) and a decongestant (pseudoephedrine). Taking Claritin-D (loratadine / pseudoephedrine) with another product containing an antihistamine or decongestant can raise your risk of side effects, such as high blood pressure, headache, and trouble urinating. Talk with your pharmacist if you have trouble choosing a Mucinex product that you can take with Claritin-D (loratadine / pseudoephedrine).
                How long does Claritin-D (loratadine / pseudoephedrine) take to work?
                In general, Claritin-D (loratadine / pseudoephedrine) can take 30 minutes to over 1 hour to start working. Loratadine generally works within 1 to 3 hours, while pseudoephedrine takes about 30 minutes to 1 hour. So it's possible that you might feel start to feel some of your allergy symptoms get better sooner than others.
                GoodRxEducationalIcon

                How to save using GoodRx

                Compare Prices
                1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
                Select your free coupon
                2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
                Show coupon to your pharmacist
                3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
                Get free couponLearn more
                warings-icon

                What are the risks and warnings for Claritin-D (loratadine / pseudoephedrine)?

                Claritin-D (loratadine / pseudoephedrine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Fast heart rate and high blood pressure

                • Risk factors: Heart problems | High blood pressure

                  Claritin-D (loratadine / pseudoephedrine) can raise your heart rate and blood pressure, even at recommended doses. If you have a history of heart problems or high blood pressure, ask your provider if Claritin-D (loratadine / pseudoephedrine) is safe for you before using this medication. If you get severe headaches, nosebleeds, difficulty breathing, irregular heartbeat, or chest pain while taking Claritin-D (loratadine / pseudoephedrine), stop taking it and get medical attention right away. These can be signs of seriously high blood pressure.

                  risk-warning

                  Possible drowsiness

                  • Risk factors: Drinking alcohol while taking Claritin-D (loratadine / pseudoephedrine) | Taking other medications that cause drowsiness

                    Claritin-D (loratadine / pseudoephedrine) might make you drowsy, which can affect your ability to focus, think, or react. This side effect is more likely to happen if you drink alcohol while taking this medication or take other medications that also cause sleepiness (e.g., opioids, certain anxiety medications, sleep medications). Don't drive or operate machinery until you know how Claritin-D (loratadine / pseudoephedrine) affects you.

                    risk-warning

                    Worsening of medical conditions

                    • Risk factors: Heart disease or high blood pressure | Thyroid problems | Diabetes | Urinary problems | Enlarged prostate | Liver or kidney problems

                      Don't take Claritin-D (loratadine / pseudoephedrine) if you have any of the risk factors listed above unless your provider said it's safe to do so. Taking Claritin-D (loratadine / pseudoephedrine) can worsen the symptoms of certain conditions. And sometimes, having certain other medical conditions can raise your risk of side effects from Claritin-D (loratadine / pseudoephedrine). Make sure your provider knows about all medical conditions you have or have had in the past before starting Claritin-D (loratadine / pseudoephedrine). They can discuss with you about whether this medication is safe for you to take.

                      risk-warning

                      Accidental overdose

                      Claritin-D (loratadine / pseudoephedrine) contains an antihistamine (loratadine) and a decongestant (pseudoephedrine), which are found in many other over-the-counter products. Using more than one medication containing an antihistamine (including products used on the skin) or a decongestant can lead to an accidental overdose and cause serious side effects. These side effects can include high blood pressure, sleepiness, dizziness, seizures, hallucinations (seeing things that aren't real), or even death.

                      Tell your provider or pharmacist about all the medications you take before starting Claritin-D (loratadine / pseudoephedrine) to make sure it's safe for you. Don't start any new medications while taking Claritin-D (loratadine / pseudoephedrine) without talking to your provider or pharmacist. To prevent an accidental overdose, read package labels carefully. If you're not sure if a product has an antihistamine or a decongestant, ask your pharmacist. If you or your loved one experiences an accidental overdose, get medical help right away or contact a poison control center at 1-800-222-1222.

                      dosage

                      Claritin-D (loratadine / pseudoephedrine) dosage forms

                      The average cost for 30 tablets of 24 hour of Claritin-D (loratadine / pseudoephedrine) is $13.61 with a free GoodRx coupon. This is 69.62% off the average retail price of $44.80.
                      tablet
                      Tablet
                      DosageQuantityPrice as low asPrice per unit
                      12 hour60 tablets$26.43$0.44
                      24 hour30 tablets$13.61$0.45

                      Typical dosing for Claritin-D (loratadine / pseudoephedrine)

                      • 24-hour tablet: Each tablet contains 10 mg of loratadine and 240 mg of pseudoephedrine.

                        • People 12 years and older: The typical dose is 1 tablet by mouth once per day. Don't take more than 1 tablet in a 24-hour period.

                        • People with liver or kidney problems: Ask your provider.

                        • Children younger than 12 years: Ask your child's provider.

                      • 12-hour tablet: Each tablet contains 5 mg of loratadine and 120 mg of pseudoephedrine.

                        • People 12 years and older: The typical dose is 1 tablet by mouth once every 12 hours. Don't take more than 2 tablets in a 24-hour period.

                        • People with liver or kidney problems: Ask your provider.

                        • Children younger than 12 years: Ask your child's provider.

                      drug-cost

                      How much does Claritin-D (loratadine / pseudoephedrine) cost?

                      To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                      Claritin-D (brand)
                      GoodRx lowest price

                      $13.61

                      (save 77.71%)
                      Claritin-D (loratadine / pseudoephedrine) (generic)
                      GoodRx lowest price

                      $13.61

                      (save 69.62%)
                      View prices & coupons
                      contraindications-icon

                      Claritin-D (loratadine / pseudoephedrine) contraindications

                      Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Claritin-D (loratadine / pseudoephedrine) will not be safe for you to take.

                      • Currently take or have taken an MAOI in the last 14 days

                      alternatives

                      What are alternatives to Claritin-D (loratadine / pseudoephedrine)?

                      There are a number of medications that your doctor can prescribe in place of Claritin-D (loratadine / pseudoephedrine). Compare a few possible alternatives below.
                      Claritin-D (loratadine / pseudoephedrine)
                      Used for:

                      Short-term relief of allergy symptoms:

                      • Runny nose

                      • Itchy nose or throat

                      • Itchy or watery eyes

                      • Stuffy nose

                      • Nasal congestion

                      • Sinus congestion or pressure

                      $13.61 Lowest GoodRx priceView Prices
                      Brompheniramine/phenylephrine
                      Used for:

                      • Nasal congestion

                      • Runny nose

                      • Sneezing

                      • Itching of the nose or throat

                      • Itchy or watery eyes

                      $4.83 Lowest GoodRx priceView Prices
                      Benadryl Plus Congestion (diphenhydramine / phenylephrine)
                      Used for:

                      • Runny nose

                      • Sneezing

                      • Itchy nose or throat

                      • Itchy, watery eyes

                      • Stuffy nose (nasal congestion)

                      • Sinus congestion and pressure

                      View Prices
                      latest news

                      What is the latest news about Claritin-D (loratadine / pseudoephedrine)?

                      Choosing the right antibiotic for sinus infections matters. See why a Z-Pak isn’t always the right solution, and get tips from GoodRx.

                      What’s the Best Antibiotic for a Sinus Infection?

                      Choosing the right antibiotic for sinus infections matters. See why a Z-Pak isn’t always the right solution, and get tips from GoodRx.
                      Postnasal drip treatment will vary depending on what causes it. Most healthcare professionals recommend using humidifiers and saline rinses to stop postnasal drip.

                      What Causes Postnasal Drip (PND)? Plus 6 Ways to Stop It

                      Postnasal drip treatment will vary depending on what causes it. Most healthcare professionals recommend using humidifiers and saline rinses to stop postnasal drip.
                      Taking oral decongestants long term can increase your risk of side effects. Here’s what healthcare experts recommend for how long it’s safe to take decongestants.

                      How Long Can You Take Oral Decongestants Like Sudafed?

                      Taking oral decongestants long term can increase your risk of side effects. Here’s what healthcare experts recommend for how long it’s safe to take decongestants.
                      Read on to see how often you should take your allergy medication and how long they typically take to work.

                      How Long Does It Take for Allergy Medicine to Work, and Should You Take It Every Day?

                      Read on to see how often you should take your allergy medication and how long they typically take to work.
                      What can cause your breast milk to dry up? Sudafed (pseudoephedrine), Clomid (clomiphene), and estrogen-containing birth control are all possible causes.

                      3 Medications That Can Dry Up Your Breast Milk Supply

                      What can cause your breast milk to dry up? Sudafed (pseudoephedrine), Clomid (clomiphene), and estrogen-containing birth control are all possible causes.
                      Sudafed (pseudoephedrine), which can help treat a stuffy nose, may cause uncomfortable side effects. Here’s how long this decongestant stays in your system.

                      How Long Does Sudafed Stay in Your System? Plus, 7 More Sudafed FAQs

                      Sudafed (pseudoephedrine), which can help treat a stuffy nose, may cause uncomfortable side effects. Here’s how long this decongestant stays in your system.
                      Medications that are likely to cause constipation include opioids, antidepressants, antihistamines, and high blood pressure medications. Dietary changes and stool softeners can help bring some relief.

                      8 Types of Medications That Can Cause Constipation

                      Medications that are likely to cause constipation include opioids, antidepressants, antihistamines, and high blood pressure medications. Dietary changes and stool softeners can help bring some relief.
                      Did you know that GoodRx can help you save up to 80% on hundreds of over-the-counter prescriptions? GoodRx coupons can be used for popular non-prescription products, including diabetes test strips, vitamins, patches and many more. But before you head to the pharmacy, you need to know that using GoodRx coupons for non-prescription products works a bit differently than you may be used to.

                      How to Use a GoodRx Coupon with Your Over-The-Counter Medication

                      Did you know that GoodRx can help you save up to 80% on hundreds of over-the-counter prescriptions? GoodRx coupons can be used for popular non-prescription products, including diabetes test strips, vitamins, patches and many more. But before you head to the pharmacy, you need to know that using GoodRx coupons for non-prescription products works a bit differently than you may be used to.
                      images

                      Claritin-D (loratadine / pseudoephedrine) images

                      This medicine is Colorless, Round Tablet.
                      White Oblong Rx724 - Walgreens Non-Drowsy Allergy Relief D 24 Hour Nasal Decongestant 10mg-240mg Extended-Release Tablet
                      This medicine is White, Oblong Tablet Imprinted With "Rx724".White Oblong Rx724 - Walgreens Non-Drowsy Allergy Relief D 24 Hour Nasal Decongestant 10mg-240mg Extended-Release Tablet

                      Get savings updates for Claritin-D (loratadine / pseudoephedrine)

                      Receive price alerts, news, and other messages from GoodRx about Claritin-D (loratadine / pseudoephedrine) and other healthcare topics and relevant savings offers.

                      By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                      References

                      Best studies we found

                      Bayer HealthCare LLC. (2022). CLARITIN-D 24 HOUR- loratadine and pseudoephedrine sulfate tablet, extended release [package insert]. DailyMed.

                      Bronsky, E., et al. (1995). Comparative efficacy and safety of a once-daily loratadine-pseudoephedrine combination versus its components alone and placebo in the management of seasonal allergic rhinitis. The Journal of Allergy and Clinical Immunology.

                      Głowacka, K., et al. (2021). Pseudoephedrine—Benefits and risks. International Journal of Molecular Sciences.

                      View All References (4)

                      Johnson, D. A., et al. (1993). The pharmacology of alpha-adrenergic decongestants. Pharmacotherapy.

                      Patel, R. H., et al. (2023). Biochemistry, histamine. StatPearls.

                      Sidhu, G., et al. (2023). Loratadine. StatPearls.

                      U.S. Food and Drug Administration. (2017). Legal requirements for the sale and purchase of drug products containing pseudoephedrine, ephedrine, and phenylpropanolamine.

                      GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                      Was this page helpful?

                      Browse medications

                      View All

                      Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.