Triprolidine
Triprolidine is an over-the-counter antihistamine. It's used to relieve allergy symptoms, such as runny nose, sneezing, and watery eyes for both children and adults. This medication comes as a liquid that's taken by mouth every 4 to 6 hours. Some side effects you might experience from triprolidine include sleepiness, dizziness, and blurry vision.
What is Triprolidine?
What is Triprolidine used for?
- Short-term relief of allergy symptoms (e.g., runny nose, sneezing, itching of the nose or throat, watery eyes)
How Triprolidine works
Triprolidine is a first-generation antihistamine. It blocks histamine, a natural chemical in your body that can cause allergy symptoms like itchiness, itchy eyes, or runny nose. By blocking histamine, triprolidine helps relieve allergy symptoms.
Drug facts
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Side effects of Triprolidine
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Sleepiness
- Feeling unsteady on your feet
- Dizziness
- Blurry vision
- Dry mouth
Less Common Side Effects
- Confusion
- Upset stomach
- Constipation
- Headache
Triprolidine serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Excessive sleepiness or dizziness
- Accidentally taking too much medication: fast heartbeat, flushing, extreme sleepiness, hallucinations, changes in vision, irritability in children
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Pros and cons of Triprolidine
Pros
- Can be used in children as young as 6 years old (if younger, ask your child's provider first)
- Good option for people who can't or don't prefer to take pills by mouth
- Available as a lower-cost generic
Cons
- Can make you feel sleepy or dizzy
- Can cause hyperactivity in some children
- Not the best choice for people over 65 years old or people with glaucoma, breathing problems, or urinary problems
Pharmacist tips for Triprolidine
- Take triprolidine with or without food. If it hurts your stomach, try taking it with food to help.
- Use a medication dose cup or an oral syringe to measure your dose of triprolidine. Ask your pharmacy to provide you with one if the product doesn't include it in its packaging or if you need extras. Don't use household spoons because they might not be accurate and might cause you to take the wrong dose.
- Triprolidine can make you sleepy and dizzy. Don't drive until you know how this medication affects you. It's best to avoid drinking alcohol while taking this medication because it can make sleepiness and dizziness worse.
- While triprolidine can make adults feel sleepy, this medication can sometimes make children feel overly-excited or energetic. If this happens to your child, speak to your child's provider. They can recommend other allergy medications for your child.
- Tell your provider or pharmacist about all the medications you're taking, including over-the-counter medications and supplements, to make sure triprolidine is safe for you. Don't start any new medications while taking triprolidine, especially other antihistamines, without talking to your provider or pharmacist first. Doing so can raise your risk of overdose and serious side effects, including confusion and extreme sleepiness.
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Common questions about Triprolidine
Oral antihistamines, like triprolidine, can relieve allergy symptoms a few hours after a dose. A small study of people who took triprolidine for skin rashes noticed their skin improving about 2 hours for triprolidine after a single dose. If you don't notice your allergy symptoms getting better after taking triprolidine, talk with your provider.
Yes, it's possible for triprolidine to make you sleepy or dizzy. Avoid alcohol while taking triprolidine because it can worsen sleepiness or dizziness. Also, don't drive or do anything that requires concentration until you know how this medication affects you.
Yes, you can take triprolidine if you have high blood pressure. But you should avoid any triprolidine combination medications that contains pseudoephedrine, such as Aprodine (pseudoephedrine / triprolidine). The pseudoephedrine component of the medication isn't a good choice because it can further raise your blood pressure. Ask your pharmacist if you're not sure which triprolidine product you should be using.
No, you shouldn't take triprolidine and diphenhydramine (Benadryl) at the same time. They're both antihistamines and taking them together can worsen side effects such as dizziness and confusion.
Triprolidine isn't a cough suppressant and won't help control your cough reflexes. It's an antihistamine that helps with certain allergy symptoms. But if you've a cough that's caused by allergy-related post nasal drip, it's possible that taking triprolidine can help ease your cough. That's because this medication can relieve some of the symptoms of post nasal drip, like runny nose, that triggers your cough.
There's not enough information to say for sure if triprolidine is safe to take while pregnant. The American College of Obstetricians and Gynecologists (ACOG) generally recommends first-generation antihistamines like triprolidine as an alternative to the first-choice antihistamine chlorpheniramine after the first trimester of pregnancy. If you're pregnant or thinking of becoming pregnant, don't use triprolidine until you've talked to your provider first about the risks and benefits of taking the medication.
Limited research suggests that taking occasional, smaller doses of triprolidine isn't expected to cause side effects in a breastfed baby. But taking larger doses, or long-term use of triprolidine, might lower milk production and cause sleepiness and drowsiness in babies. If you're breastfeeding, discuss with your provider about the risks and benefits of using triprolidine to make sure it's safe for you and your baby.
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Risks and warnings for Triprolidine
Triprolidine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Sleepiness
- Risk factors: Drinking alcohol | Taking other medications that cause sleepiness | Age 65 and older
Triprolidine can make you sleepy, which can affect your ability to focus, think, or react. This side effect is more likely to happen or be more intense if you're over 65 years old, drink alcohol while taking triprolidine, or take other medications that cause sleepiness (e.g., opioids, benzodiazepines, sleep medications). It's best to avoid alcohol and other medications that might make you sleepy while taking triprolidine. Don't drive or operate machinery until you know how this medication affects you.
Worsening of medical conditions
- Risk factors: Glaucoma | Urinary problems (e.g., large prostate gland, bladder neck blockage) | Breathing problems (e.g., emphysema or long-term bronchitis)
Don't take triprolidine if you have any of the risk factors listed above unless your provider said it's safe to do so. Taking this medication can worsen your condition(s) and cause serious side effects. Make sure your provider knows about all medical conditions you have or have had in the past before starting triprolidine.
Accidental overdose
Triprolidine is an antihistamine, which is in many other over-the-counter products. Taking more than one medication containing an antihistamine can lead to serious side effects, such as blurry vision, reddening of skin, and confusion.
Don't start any new medications while taking triprolidine without talking to your provider or pharmacist first. To prevent an accidental overdose, read package labels carefully. If you're not sure if a product has an antihistamine, ask your provider or pharmacist.
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Triprolidine dosage
Dropper| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 30ml of 0.625mg/ml | 1 dropper | $9.76 | $9.76 |
| 30ml of 0.938mg/ml | 1 dropper | $11.64 | $11.64 |
| 50ml of 1.25mg/2ml | 1 dropper | $10.67 | $10.67 |
Typical dosage for Triprolidine
Triprolidine products come in different concentrations, meaning they can differ in the dosage of triprolidine per milliliter (mL) of liquid. Follow the manufacturer's direction on the label for specific dosing instructions for your product.
In general:
- Adults and children ages 12 years or older: The typical dose is to take 2.5 mg by mouth every 4 to 6 hours. Don't take more than 10 mg in 24 hours, unless directed by your provider.
- Children ages 6 to under 12 years old: The typical dose is to take 1.25 mg by mouth every 4 to 6 hours. Don't take more than 5 mg in 24 hours, unless directed by your provider.
- Children ages 6 years and under: Ask your child's provider.
How much does Triprolidine cost?
$9.76
