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Substance Use

Is It Safe to Drink Alcohol with Antihistamines?

Hilary WeissmanSanjai Sinha, MD
Written by Hilary Weissman | Reviewed by Sanjai Sinha, MD
Updated on September 11, 2025
Reviewed by Sanjai Sinha, MD | September 11, 2025

Your allergies are acting up, and you’ve got a supply of non-drowsy allergy medicines at the ready. So, is it a bad idea to party with alcohol and take antihistamines at the same time? This time, you might want to throw away your shot.

However, the reactions are different in different people. Some people might tolerate one to two drinks while taking antihistamines, since alcohol tolerance can vary among different ages and sexes. Talk to your doctor before taking antihistamines to learn your risks, but to be on the safe side — it’s probably wise to stick to mocktails until your allergies clear up.

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Hilary Weissman
Written by:
Hilary Weissman
Hilary Weissman has been a health writer for the past 6 years. She was a senior copywriter at WW (Weight Watchers) before joining GoodRx and was also a copy editor in S&P Global’s structured finance ratings group for 3 years prior.
Sanjai Sinha, MD
Reviewed by:
Sanjai Sinha, MD
Sanjai Sinha, MD, is a board-certified physician with over 20 years of experience. He specializes in internal medicine.

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