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Atrovent vs. Combivent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Atrovent HFA (ipratropium) and Combivent Respimat (ipratropium/albuterol) are both used to help with breathing issues, but they have different uses and forms. Atrovent HFA is an inhaled anticholiergic medication used as maintenance treatment for chronic obstructive pulmonary disease (COPD). It works by blocking acetylcholine in the lungs, which allows the muscles in your airway to relax, making it easier to breathe. Combivent Respimat, on the other hand, is an inhaler used to treat chronic obstructive pulmonary disease (COPD) and contains a combination of ipratropium and albuterol. This means combines the effects of a short-acting muscarinic antagonist (SAMA) and a short-acting beta-agonist (SABA) to relax and open airways. Both medications are brand-name only. Atrovent HFA is typically used four times a day, whereas Combivent Respimat is used up to 6 times a day for breathing issues.

ipratropium nasal spray

 

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Combivent Respimat

(ipratropium / albuterol)

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Summary for Atrovent

Prescription only

Ipratropium nasal spray is a prescription nasal spray used to treat runny nose from allergies and from the common cold. Depending on the strength, it can be used in people ages 5 or 6 years and older. It's only available as a generic medication since the brand name, Atrovent, has been discontinued. Dosing for ipratropium nasal spray typically ranges from 2 sprays in each nostril, 2 to 4 times daily. Although most people experience few to no side effects while using ipratropium nasal spray, some people might have headache or nosebleeds during treatment.

Indications for Atrovent

  • Runny nose due to year-round allergies, seasonal allergies, and the common cold

Pros and Cons for Atrovent

Pros

  • Starts to work in as quickly as 15 minutes
  • Available as a lower-cost generic medication
  • Safe to use for children 5 or 6 years of age and older

Cons

  • Not sure if safe or works well in people with kidney or liver conditions
  • Needs to be used multiple times a day
  • Might worsen certain medical conditions, such as glaucoma or prostate problems

Common Side Effects for Atrovent

Ipratropium 0.06% nasal spray

Ipratropium 0.03% nasal spray

  • Headache (10%)
  • Cough, runny nose, and other symptoms of respiratory infections (10%)
  • Nosebleed (9%)
  • Sore throat (8%)
  • Dry nose (5%)

Warnings for Atrovent

  • Allergic reactions
  • Vision and eye problems
  • Worsening of certain medical conditions

Summary for Combivent

Prescription only

Combivent Respimat is an inhaler that's used to treat chronic obstructive pulmonary disease (COPD) in adults. It's a combination medication that contains two different bronchodilators: ipratropium, a short-acting muscarinic antagonist (SAMA), and albuterol, a short-acting beta agonist (SABA). The medication is inhaled through the mouth 4 times a day, but up to 6 times per day if instructed. Combivent Respimat (ipratropium / albuterol) isn't a rescue inhaler; it's used regularly rather than as needed for sudden breathing problems. Side effects aren't common but can include upper respiratory tract infections and cough.

Indications for Combivent

Pros and Cons for Combivent

Pros

  • Combines two different bronchodilators within a single inhaler for convenience
  • Can start to work in about 15 minutes to help with breathing for some people
  • Doesn't require shaking before use
  • Don't need to rinse your mouth after use

Cons

  • Not a rescue inhaler
  • Might need to use up to 6 times per day, depending on the severity of your COPD symptoms
  • Might not be a good option for people with heart problems
  • No lower-cost generic; only available as a brand-name medication

Common Side Effects for Combivent

Warnings for Combivent

  • Narrowing of the airways (bronchospasm)
  • Effects on the heart and blood pressure
  • Eye problems
  • Trouble urinating
  • Severe allergic reaction
  • Low potassium in the blood

Prices with our coupons for Atrovent vs. Combivent

Price Card Drug Icon
Ipratropium25 vials / 2.5ml of 0.02%
$14.40$74.58
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Price Card Drug Icon
Combivent1 respimat inhaler / 120 doses of 20mcg/100mcg
$503.40$648.88
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