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Compare Advair vs. Trelegy Ellipta

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Advair (fluticasone / salmeterol)
Trelegy ellipta
Advair (fluticasone / salmeterol)
Trelegy ellipta

Summary of Advair vs. Trelegy Ellipta

Summary for ICS / LABA combo
Prescription only

Advair is a combination inhaler that contains fluticasone (an inhaled corticosteroid) and salmeterol (a long-acting beta agonist, or LABA). Advair Diskus is used for maintenance treatment of chronic obstructive pulmonary disease (COPD) and asthma in adults and children, where as Advair HFA is for asthma only. Advair (fluticasone / salmeterol) is inhaled through the mouth, typically 1 to 2 puffs twice daily. Some common side effects of this medication include upper respiratory tract infection, sore throat, and headache.

Summary for ICS / LAMA / LABA
Prescription only

Trelegy Ellipta aerosol powder is a combination inhaler that contains fluticasone (a corticosteroid), umeclidinium (a long-acting muscarinic antagonist), and vilanterol (a long-acting beta agonist). It's used for maintenance treatment of chronic obstructive pulmonary disease (COPD) and asthma in adults. Trelegy Ellipta is inhaled through the mouth once per day. Some possible side effects include upper respiratory tract infections, headache, and cough. Trelegy Ellipta is brand name only and not available as a generic medication.

Indications of Advair vs. Trelegy Ellipta

Indications for
•Maintenance treatment of asthma
•Maintenance treatment of COPD - Advair Diskus 250/50 only
Indications for
•Maintenance treatment of asthma
•Maintenance treatment of chronic obstructive pulmonary disease (COPD)

Pros and Cons of Advair vs. Trelegy Ellipta

Pros and Const for ICS / LABA combo
Pros
•Works well to lower the risk of asthma or COPD symptoms
•Combines two medications into a single inhaler for convenience
•Available as two different types of inhalers (Advair Diskus and Advair HFA)
Cons
•Can cause fungal infections (thrush) in your mouth and throat
•Advair Diskus contains lactose, so it might not be safe for people with severe milk protein allergies
•Doesn't replace your rescue inhaler
Pros and Const for ICS / LAMA / LABA
Pros
•Inhaled once per day
•Combination of three medications within a single inhaler
•The Ellipta device might be easier to use compared to some other dry powder inhalers
Cons
•Can't use if you're severely allergic to milk proteins because it contains lactose
•Need to rinse your mouth after each dose to prevent fungal infections (thrush) in the mouth or throat
•Not available as a lower-cost generic

Common Side Effects of Advair vs. Trelegy Ellipta

Common Side Effects for

Advair Diskus:

•Upper respiratory infection (up to 27%)
•Sore throat (up to 13%)
•Headache (up to 13%)
•Bronchitis (up to 8%)
•Cough (up to 6%)
•Nausea and vomiting (up to 6%)
•Hoarseness (up to 5%)

Advair HFA:

•Upper respiratory infection (up to 24%)
•Headache (up to 21%)
•Throat irritation (up to 9%)
•Muscle and bone pain (up to 7%)
•Nausea and vomiting (up to 5%)
Common Side Effects for

COPD:

•Headache (4%)
•Back pain (4%)
•Changes in taste (2%)
•Diarrhea (2%)

Asthma:

•Common cold or sore throat (up to 17%)
•Headache (up to 9%)
•Upper respiratory tract infection (up to 7%)
•Bronchitis (up to 5%)
•Sinus infection (up to 3%)
•Back pain (up to 3%)

Warnings of Advair vs. Trelegy Ellipta

Common Side Effects for
•Not for use in asthma attack or for worsening breathing
•Fungal infection in the mouth
•Narrowing of your airways (bronchospasm)
•Higher risk of infections
•Altered stress hormone levels
•Delayed growth in children
•Eye and vision problems
•Heart problems
•Low potassium levels in the blood
•Allergic reactions
Common Side Effects for
•Not for asthma, COPD flare ups, or worsening breathing
•Fungal infection in the mouth
•Narrowing of your airways (bronchospasm)
•Allergic reactions
•Higher risk of infections
•Changes in stress hormone levels
•Delayed growth in children
•Eye and vision problems
•Heart problems
•Low potassium levels in the blood
•Trouble urinating
•Low potassium in the blood

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