Trelegy Ellipta aerosol powder is a combination inhaler that contains fluticasone (a corticosteroid), umeclidinium (a long-acting muscarinic antagonist), and vilanterol (a long-acting beta agonist). It's used for maintenance treatment of chronic obstructive pulmonary disease (COPD) and asthma in adults. Trelegy Ellipta is inhaled through the mouth once per day. Some possible side effects include upper respiratory tract infections, headache, and cough. Trelegy Ellipta is brand name only and not available as a generic medication.
Maintenance treatment of asthma
Maintenance treatment of chronic obstructive pulmonary disease (COPD)
Trelegy Ellipta is a combination of three medications that work together to help you breathe easier.
Fluticasone is an inhaled corticosteroid. It's thought to lower inflammation and swelling in the lungs.
Umeclidinium is a long-acting muscarinic antagonist (LAMA), a type of anticholinergic medication. It blocks acetylcholine to relax the muscles in your airways.
Vilanterol is a long-acting beta agonist. It relaxes the muscles in your lungs to open up your airways.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Inhaled once per day
Combination of three medications within a single inhaler
The Ellipta device might be easier to use compared to some other dry powder inhalers
Can't use if you're severely allergic to milk proteins because it contains lactose
Need to rinse your mouth after each dose to prevent fungal infections (thrush) in the mouth or throat
Not available as a lower-cost generic
Use Trelegy Ellipta once per day at the same time every day to prevent COPD or asthma attacks. You can take Trelegy Ellipta at any time of the day, but you must take it every day for it to work well for you.
Use a rescue inhaler such as albuterol (Ventolin) if you have sudden trouble breathing during a COPD or asthma attack. Trelegy Ellipta won't treat sudden breathing problems as it's happening.
Call your pulmonologist if your breathing or peak flow meter results worsen. Also contact your pulmonologist if you're using your rescue inhaler more often than usual. These could be signs that your Trelegy Ellipta dose is too low, or you need another long-acting medication to help manage your asthma or COPD.
Don't start any new medications while you're taking Trelegy Ellipta without asking your pulmonologist or primary care provider first. Trelegy Ellipta can interact with other medications, such as blood pressure medications (e.g., beta blockers) and tricyclic antidepressants. Your healthcare providers can check for interactions to make sure your medications are safe to take.
Store Trelegy Ellipta at room temperature in a dry place away from heat or sunlight. Keep unused inhalers in the original foil pouch.
Tips for how to use Trelegy Ellipta:
Trelegy Ellipta comes in two different strengths: 100 mcg/62.5 mcg/25 mcg and 200 mcg/62.5 mcg/25 mcg of fluticasone/umeclidinium/vilanterol per inhalation. Your prescriber will adjust your dose, or prescribe you a new strength, based on how you respond to the medication. Make sure you know which strength you have and what your dose of Trelegy Ellipta is.
Trelegy Ellipta expires 6 weeks after you remove it from the foil tray. Write the expiration ("use by") date on the first blank line on the inhaler.
There's a dose counter on the front face of the Trelegy Ellipta inhaler. It should say "30" for a new inhaler. Use this counter to keep track of when you need to get a refill.
You don't need to prime or shake the Trelegy Ellipta inhaler before using it. Each time you open the cover of the inhaler, you're preparing 1 dose. Only open the cover of the inhaler if you're about to take a dose.
When you're ready to take your dose, slide the cover on the Trelegy Ellipta inhaler until it clicks and hold in a flat position, like a hamburger. Then, breathe out as long as you can, away from the inhaler. Then, without blocking the vent, place your lips firmly around the mouthpiece and take a long, steady, and deep breath in through your mouth.
After you inhale from the Trelegy Ellipta inhaler, try to hold your breath for 3-4 seconds, or for as long as you comfortably can. This allows the medication to reach deep into your lungs.
After you're done using Trelegy Ellipta, rinse your mouth with water and then spit. This helps lower the risk of a fungal infection in the mouth and throat (thrush).
Never wash the Trelegy Ellipta inhaler with water or any liquid. Instead, clean the mouthpiece every once in a while by wiping it with a dry cloth. Just make sure you don't get water or moisture on or near the inhaler. Moisture can make the dry powder medication clump together and clog the inhaler.
Trelegy Ellipta can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Don't use Trelegy Ellipta if you're experiencing an asthma or COPD attack because this medication won't provide immediate relief. Use a rescue inhaler, such as albuterol (Ventolin HFA), if you're having trouble breathing.
If you're using your rescue inhaler more often than usual, let your pulmonologist know because this could be a sign that your condition is getting worse. Don't use more doses of Trelegy Ellipta than recommended because this won't improve your breathing. Rather, this can raise your risk for serious side effects, such as heart problems, tremors, and dizziness.
In addition, don't use Trelegy Ellipta with other inhalers containing a LABA, such as Serevent Diskus (salmeterol) or formoterol (Perforomist). Doing so can also worsen side effects.
Risk factors: Not rinsing and spitting after using Trelegy Ellipta | Weakened immune system from medical conditions or medications
Trelegy Ellipta contains fluticasone, a steroid medication. When inhaled, it can cause a fungal infection in your mouth and throat called thrush. To lower your risk for thrush, rinse your mouth with water and spit after each inhalation of Trelegy Ellipta. If you develop thrush, your pulmonologist might prescribe you a medication to treat this condition and ask you to temporarily stop using Trelegy Ellipta. Let your pulmonologist know if you notice symptoms of thrush, such as white patches in your mouth, cotton-like feeling in your mouth, pain while eating or swallowing, or loss of taste.
Inhaled medications, including Trelegy Ellipta, can sometimes cause a muscle spasm in your lungs. This can lead to difficulty breathing, wheezing, cough, and chest discomfort. If you have a hard time breathing after inhaling Trelegy Ellipta, use your rescue inhaler and get medical attention right away.
Risk factors: Allergy to milk proteins (lactose)
Allergic reactions to Trelegy Ellipta are possible. These reactions can include life-threatening facial swelling, shock, and anaphylaxis (closing of the throat). Get medical attention right away if you notice hives, rash, red skin, swelling of the lips or tongue, or difficulty breathing after you use Trelegy Ellipta.
Like all corticosteroid-containing medications, Trelegy Ellipta can weaken your immune system and raise your risk for infections, including upper respiratory infections and pneumonia. Your risk for infections is higher if you're also taking other medications that also weaken your immune system. If you're currently being treated for a serious infection, such as tuberculosis, let your pulmonologist know. They might need to consider a different medication for your condition until you get better. Let your pulmonologist or primary care provider know right away if you have symptoms of infections, such as fever, chills, or body aches.
Risk factors: Using Trelegy Ellipta for a long time | Using too much Trelegy Ellipta
Use Trelegy Ellipta only as directed. Don't use more than the maximum number of inhalations each day. Doing so can cause more of the steroid to be absorbed into the body and raise your risk for symptoms such as higher blood sugar or blood pressure levels.
On the other hand, if you're transitioning to Trelegy Ellipta from oral steroids, you might experience symptoms of low steroid hormone, such as stomach pain, loss of appetite, and nausea. When you transition to Trelegy Ellipta, your pulmonologist will work with you to lower your dose of oral steroids slowly over time to prevent these side effects.
Children who use inhaled steroids, like Trelegy Ellipta, might experience a delay in growth. Currently, Trelegy Ellipta is only approved for adults and shouldn't be used by children.
Risk factors: Long-term use of Trelegy Ellipta | History of glaucoma | History of high eye pressure
Although rare, people using inhaled steroids or anticholinergics over a long period of time have reported having higher pressure in the eyes, glaucoma, and cataracts. Since Trelegy Ellipta contains fluticasone (a steroid) and umeclidinium (an anticholinergic), talk to your optometrist before using Trelegy Ellipta if you have glaucoma or cataracts because they might ask you to come in more often for eye exams. Also speak with them if you notice any changes to your vision while using the medication.
Risk factors: High blood pressure | Heart failure | Heart rate or rhythm problems | Using more Trelegy Ellipta than recommended
The vilanterol in Trelegy Ellipta might cause changes in your blood pressure, heart rate, and heart rhythm. But these side effects are typically unlikely to happen if you're taking the recommended dose of Trelegy Ellipta. Your pulmonologist or cardiologist might ask you to regularly check your blood pressure and heart rate at home if you have high blood pressure or other heart problems. Don't use Trelegy Ellipta more often than recommended. If you find that you need to use Trelegy Ellipta more often, let your care team know so they can see if you need any changes to your treatment plan. Tell your pulmonologist if you have dizziness, fatigue, tremor, rapid heartbeat, or weakness after you use Trelegy Ellipta.
Risk factors: Using Trelegy Ellipta too much
Vilanterol in Trelegy Ellipta can cause the potassium levels in your blood to drop too low. In most cases, this happens if you use more Trelegy Ellipta than recommended. Drops in blood potassium levels are typically mild and your levels should go back to usual with time. Sometimes, low potassium can cause tiredness, weakness, muscle cramps, a racing heart, and a "pins and needles" feeling in your hands and feet. Tell your prescriber if you experience any of these symptoms while you're using Trelegy Ellipta. Also let your prescriber know if you need to use Trelegy Ellipta more often than instructed. Your treatment plan might need to be adjusted to better control your symptoms.
Risk factors: Enlarged prostate | Bladder-neck obstruction (blockage)
Trelegy Ellipta should be used cautiously by people who have prostate problems or urinary retention. This is because umeclidinium in Trelegy Ellipta can cause difficulty urinating. Contact your prescriber if you notice difficulty urinating while using this medication.
Risk factors: Taking too much Trelegy Ellipta
Trelegy Ellipta can sometimes cause the potassium levels in your blood to drop too low. This is more likely to happen if you take too much Trelegy Ellipta. Symptoms of low potassium include tiredness, weakness, muscle cramps, and a racing heart. Don't take more Trelegy Ellipta than prescribed. Seek medical help right away if Trelegy Ellipta isn't helping your breathing get better.
COPD: The typical dose is 1 inhalation of 100 mcg/62.5 mcg/25 mcg (fluticasone/umeclidinium/vilanterol) by mouth once per day.
Asthma: The typical dose is 1 inhalation of 100 mcg/62.5 mcg/25 mcg or 200 mcg/62.5 mcg/25 mcg (fluticasone/umeclidinium/vilanterol) by mouth once per day.
Treatment of sudden, severe asthma or COPD attack
Allergy to fluticasone (inhaled corticosteroid), umeclidinium (an anticholinergic), or vilanterol (long-acting beta agonist)
Allergy to lactose or milk proteins
Maintenance treatment of asthma
Maintenance treatment of chronic obstructive pulmonary disease (COPD)
Maintenance treatment of chronic obstructive pulmonary disease (COPD)
Maintenance treatment of asthma in people ages 5 years and older
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