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Trelegy Ellipta Coupon - Trelegy Ellipta 60 blisters of 100mcg/62.5mcg/25mcg inhaler

Trelegy Ellipta

fluticasone / umeclidinium / vilanterol
Used for Asthma, COPD
Used for Asthma, COPD

Trelegy Ellipta aerosol powder is a combination inhaler that contains fluticasone (a corticosteroid), umeclidinium (a long-acting muscarinic antagonist), and vilanterol (a long-acting beta agonist). It's used for maintenance treatment of chronic obstructive pulmonary disease (COPD) and asthma in adults. Trelegy Ellipta is inhaled through the mouth once per day. Some possible side effects include upper respiratory tract infections, headache, and cough. Trelegy Ellipta is brand name only and not available as a generic medication.

Last reviewed on September 10, 2024
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$824.55(save 21.88%)
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$644.11
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basics-icon

What is Trelegy Ellipta?

What is Trelegy Ellipta used for?

How Trelegy Ellipta works

Trelegy Ellipta is a combination of three medications that work together to help you breathe easier.

When does Trelegy Ellipta start working?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsTrelegy Ellipta
Drug ClassICS / LAMA / LABA
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Trelegy Ellipta essentials

basics-icon

What are the side effects of Trelegy Ellipta?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

COPD:
  • Headache (4%)
  • Back pain (4%)
  • Changes in taste (2%)
  • Diarrhea (2%)
Asthma:
  • Common cold or sore throat (up to 17%)
  • Headache (up to 9%)
  • Upper respiratory tract infection (up to 7%)
  • Bronchitis (up to 5%)
  • Sinus infection (up to 3%)
  • Back pain (up to 3%)

Other Side Effects

COPD:
  • Cough
  • Mouth and throat pain
  • Thrush
  • Upper respiratory tract infection
  • Pneumonia
  • Bronchitis
  • Stomach flu
  • Flu
  • Urinary tract infections (UTI)
  • Constipation
  • Joint pain
  • Voice changes
Asthma:
  • Urinary tract infection (UTI)
  • Voice changes
  • Mouth and throat pain
  • Cough

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction: hives, swelling of your face, lips, or tongue, difficulty breathing
  • Sudden narrowing of your airways: difficulty breathing, wheezing, chest pain or tightness, cough
  • Heart problems: dizziness, fatigue, tremor, nausea, rapid heartbeat, weakness, or difficulty sleeping
When do Trelegy Ellipta possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Cough
Sore throat
Risk of respiratory tract infection
Risk of oral thrush
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Increase in blood pressure
  • Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
  • Muscle pain or cramps
  • Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
  • Thrush—white patches in the mouth
  • Trouble passing urine
  • Wheezing or trouble breathing that is worse after use

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Trelegy Ellipta

thumbs-up

Pros

Inhaled once per day

Combination of three medications within a single inhaler

The Ellipta device might be easier to use compared to some other dry powder inhalers

thumbs-down

Cons

Can't use if you're severely allergic to milk proteins because it contains lactose

Need to rinse your mouth after each dose to prevent fungal infections (thrush) in the mouth or throat

Not available as a lower-cost generic

pharmacist-tips

Pharmacist tips for Trelegy Ellipta

pharmacist
  • Use Trelegy Ellipta once per day at the same time every day to prevent COPD or asthma attacks. You can take Trelegy Ellipta at any time of the day, but you must take it every day for it to work well for you.

    • Call your pulmonologist if your breathing or peak flow meter results worsen. Also contact your pulmonologist if you're using your rescue inhaler more often than usual. These could be signs that your Trelegy Ellipta dose is too low, or you need another long-acting medication to help manage your asthma or COPD.

      • Don't start any new medications while you're taking Trelegy Ellipta without asking your pulmonologist or primary care provider first. Trelegy Ellipta can interact with other medications, such as blood pressure medications (e.g., beta blockers) and tricyclic antidepressants. Your healthcare providers can check for interactions to make sure your medications are safe to take.

        • Store Trelegy Ellipta at room temperature in a dry place away from heat or sunlight. Keep unused inhalers in the original foil pouch.

          • Trelegy Ellipta comes in two different strengths: 100 mcg/62.5 mcg/25 mcg and 200 mcg/62.5 mcg/25 mcg of fluticasone/umeclidinium/vilanterol per inhalation. Your prescriber will adjust your dose, or prescribe you a new strength, based on how you respond to the medication. Make sure you know which strength you have and what your dose of Trelegy Ellipta is.

            • Trelegy Ellipta expires 6 weeks after you remove it from the foil tray. Write the expiration ("use by") date on the first blank line on the inhaler.

              • There's a dose counter on the front face of the Trelegy Ellipta inhaler. It should say "30" for a new inhaler. Use this counter to keep track of when you need to get a refill.

                • You don't need to prime or shake the Trelegy Ellipta inhaler before using it. Each time you open the cover of the inhaler, you're preparing 1 dose. Only open the cover of the inhaler if you're about to take a dose.

                  • When you're ready to take your dose, slide the cover on the Trelegy Ellipta inhaler until it clicks and hold in a flat position, like a hamburger. Then, breathe out as long as you can, away from the inhaler. Then, without blocking the vent, place your lips firmly around the mouthpiece and take a long, steady, and deep breath in through your mouth.

                    • After you inhale from the Trelegy Ellipta inhaler, try to hold your breath for 3-4 seconds, or for as long as you comfortably can. This allows the medication to reach deep into your lungs.

                      • After you're done using Trelegy Ellipta, rinse your mouth with water and then spit. This helps lower the risk of a fungal infection in the mouth and throat (thrush).

                        • Never wash the Trelegy Ellipta inhaler with water or any liquid. Instead, clean the mouthpiece every once in a while by wiping it with a dry cloth. Just make sure you don't get water or moisture on or near the inhaler. Moisture can make the dry powder medication clump together and clog the inhaler.

                          More on Trelegy Ellipta tips

                          faqs

                          Frequently asked questions about Trelegy Ellipta

                          Is Trelegy Ellipta a steroid?
                          Yes, Trelegy Ellipta contains an inhaled corticosteroid (or steroid) called fluticasone. Its purpose is to lower inflammation in the lungs, which helps to keep your airways open and help you breathe better.
                          How long does it take for Trelegy Ellipta to work?
                          When you first start Trelegy Ellipta, you might feel improvements in your breathing within 15 minutes after a dose. But it can take a few weeks for your symptoms to be controlled by this medication. If you still don't notice improvements to your breathing after using Trelegy Ellipta for a few weeks, your pulmonologist might switch you to a higher strength of the inhaler to see if it helps. Or, they might ask you to consider other medications for your condition. Talk with your healthcare team if you have more questions about what to expect with Trelegy Ellipta.
                          Can I take Trelegy Ellipta every other day?
                          Trelegy Ellipta is typically prescribed as one inhalation by mouth daily. It's best to take this medication at the same time each day. Trelegy Ellipta hasn't been studied when taken every other day, so it's not clear how well it'll work when taken this way. Talk to your prescriber if you have more questions about how to take Trelegy Ellipta.
                          Is muscle pain a side effect of Trelegy Ellipta?
                          Yes, Trelegy Ellipta can cause muscle pain. Though not common, some people who took Trelegy Ellipta in clinical studies reported back pain as a side effect. While more research is needed to understand why this happens, studies suggest that muscle pain is linked to vilanterol, the LABA medication in Trelegy Ellipta. Other studies show that LABAs can also cause leg cramps at night. If you experience muscle pain while taking Trelegy Ellipta, talk with your healthcare team.
                          Can Trelegy Ellipta cause hoarseness?
                          Yes, hoarseness (also called dysphonia) from inhalers like Trelegy Ellipta is possible, but it's rare. In clinical studies, only 1% of people using Trelegy Ellipta reported hoarseness. Talk to your prescriber if you're concerned about hoarseness from Trelegy Ellipta.
                          Can Trelegy Ellipta cause hair loss?
                          No, hair loss wasn't a side effect reported by people using Trelegy Ellipta in clinical studies. If you notice hair loss while you're taking Trelegy Ellipta, contact your primary care provider so they can help you figure out possible causes.
                          Does Trelegy Ellipta cause weight gain?
                          People who took Trelegy Ellipta in clinical studies didn't report weight gain as a side effect. Talk with your primary care provider if you experience unexplained weight gain while taking this medication. They can help identify what might be causing it.
                          Can you take Trelegy Ellipta and Flonase together?
                          Ask your healthcare team if you can take Trelegy Ellipta and fluticasone (Flonase) nasal spray together. In general, Trelegy Ellipta and fluticasone (Flonase) don't have any major interactions. Even though both medications contain fluticasone, they're absorbed differently in the body. Trelegy Ellipta is inhaled into the lungs to help you breathe better and fluticasone (Flonase) is sprayed into the nostril to treat allergy symptoms. But fluticasone (Flonase) might not be appropriate for everyone because it might worsen asthma symptoms as a side effect. Your healthcare team can talk with you about the benefits and risks of taking Trelegy Ellipta with fluticasone (Flonase).
                          Can I take Trelegy Ellipta with albuterol?
                          Your pulmonologist will likely prescribe you albuterol (Ventolin) as a rescue inhaler when you're taking Trelegy Ellipta. This is because Trelegy Ellipta is a long-acting medication that works over time to lessen inflammation and swelling in your lungs and open your airways. But it won't help if you have sudden trouble breathing. A rescue inhaler, such as albuterol (Ventolin), works quickly and can relieve sudden symptoms, such as coughing and wheezing. Ask your healthcare team if you have more questions about Trelegy Ellipta and rescue inhalers.
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                          warings-icon

                          What are the risks and warnings for Trelegy Ellipta?

                          Trelegy Ellipta can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                          risk-warning

                          Not for asthma, COPD flare ups, or worsening breathing

                          Don't use Trelegy Ellipta if you're experiencing an asthma or COPD attack because this medication won't provide immediate relief. Use a rescue inhaler, such as albuterol (Ventolin HFA), if you're having trouble breathing.

                          If you're using your rescue inhaler more often than usual, let your pulmonologist know because this could be a sign that your condition is getting worse. Don't use more doses of Trelegy Ellipta than recommended because this won't improve your breathing. Rather, this can raise your risk for serious side effects, such as heart problems, tremors, and dizziness.

                          In addition, don't use Trelegy Ellipta with other inhalers containing a LABA, such as Serevent Diskus (salmeterol) or formoterol (Perforomist). Doing so can also worsen side effects.

                          risk-warning

                          Fungal infection in the mouth

                          • Risk factors: Not rinsing and spitting after using Trelegy Ellipta | Weakened immune system from medical conditions or medications

                            Trelegy Ellipta contains fluticasone, a steroid medication. When inhaled, it can cause a fungal infection in your mouth and throat called thrush. To lower your risk for thrush, rinse your mouth with water and spit after each inhalation of Trelegy Ellipta. If you develop thrush, your pulmonologist might prescribe you a medication to treat this condition and ask you to temporarily stop using Trelegy Ellipta. Let your pulmonologist know if you notice symptoms of thrush, such as white patches in your mouth, cotton-like feeling in your mouth, pain while eating or swallowing, or loss of taste.

                            risk-warning

                            Narrowing of your airways (bronchospasm)

                            Inhaled medications, including Trelegy Ellipta, can sometimes cause a muscle spasm in your lungs. This can lead to difficulty breathing, wheezing, cough, and chest discomfort. If you have a hard time breathing after inhaling Trelegy Ellipta, use your rescue inhaler and get medical attention right away.

                            risk-warning

                            Allergic reactions

                            • Risk factors: Allergy to milk proteins (lactose)

                              Allergic reactions to Trelegy Ellipta are possible. These reactions can include life-threatening facial swelling, shock, and anaphylaxis (closing of the throat). Get medical attention right away if you notice hives, rash, red skin, swelling of the lips or tongue, or difficulty breathing after you use Trelegy Ellipta.

                              risk-warning

                              Higher risk of infections

                              Like all corticosteroid-containing medications, Trelegy Ellipta can weaken your immune system and raise your risk for infections, including upper respiratory infections and pneumonia. Your risk for infections is higher if you're also taking other medications that also weaken your immune system. If you're currently being treated for a serious infection, such as tuberculosis, let your pulmonologist know. They might need to consider a different medication for your condition until you get better. Let your pulmonologist or primary care provider know right away if you have symptoms of infections, such as fever, chills, or body aches.

                              risk-warning

                              Changes in stress hormone levels

                              • Risk factors: Using Trelegy Ellipta for a long time | Using too much Trelegy Ellipta

                                Use Trelegy Ellipta only as directed. Don't use more than the maximum number of inhalations each day. Doing so can cause more of the steroid to be absorbed into the body and raise your risk for symptoms such as higher blood sugar or blood pressure levels.

                                On the other hand, if you're transitioning to Trelegy Ellipta from oral steroids, you might experience symptoms of low steroid hormone, such as stomach pain, loss of appetite, and nausea. When you transition to Trelegy Ellipta, your pulmonologist will work with you to lower your dose of oral steroids slowly over time to prevent these side effects.

                                risk-warning

                                Delayed growth in children

                                Children who use inhaled steroids, like Trelegy Ellipta, might experience a delay in growth. Currently, Trelegy Ellipta is only approved for adults and shouldn't be used by children.

                                risk-warning

                                Eye and vision problems

                                • Risk factors: Long-term use of Trelegy Ellipta | History of glaucoma | History of high eye pressure

                                  Although rare, people using inhaled steroids or anticholinergics over a long period of time have reported having higher pressure in the eyes, glaucoma, and cataracts. Since Trelegy Ellipta contains fluticasone (a steroid) and umeclidinium (an anticholinergic), talk to your optometrist before using Trelegy Ellipta if you have glaucoma or cataracts because they might ask you to come in more often for eye exams. Also speak with them if you notice any changes to your vision while using the medication.

                                  risk-warning

                                  Heart problems

                                  • Risk factors: High blood pressure | Heart failure | Heart rate or rhythm problems | Using more Trelegy Ellipta than recommended

                                    The vilanterol in Trelegy Ellipta might cause changes in your blood pressure, heart rate, and heart rhythm. But these side effects are typically unlikely to happen if you're taking the recommended dose of Trelegy Ellipta. Your pulmonologist or cardiologist might ask you to regularly check your blood pressure and heart rate at home if you have high blood pressure or other heart problems. Don't use Trelegy Ellipta more often than recommended. If you find that you need to use Trelegy Ellipta more often, let your care team know so they can see if you need any changes to your treatment plan. Tell your pulmonologist if you have dizziness, fatigue, tremor, rapid heartbeat, or weakness after you use Trelegy Ellipta.

                                    risk-warning

                                    Low potassium levels in the blood

                                    • Risk factors: Using Trelegy Ellipta too much

                                      Vilanterol in Trelegy Ellipta can cause the potassium levels in your blood to drop too low. In most cases, this happens if you use more Trelegy Ellipta than recommended. Drops in blood potassium levels are typically mild and your levels should go back to usual with time. Sometimes, low potassium can cause tiredness, weakness, muscle cramps, a racing heart, and a "pins and needles" feeling in your hands and feet. Tell your prescriber if you experience any of these symptoms while you're using Trelegy Ellipta. Also let your prescriber know if you need to use Trelegy Ellipta more often than instructed. Your treatment plan might need to be adjusted to better control your symptoms.

                                      risk-warning

                                      Trouble urinating

                                      • Risk factors: Enlarged prostate | Bladder-neck obstruction (blockage)

                                        Trelegy Ellipta should be used cautiously by people who have prostate problems or urinary retention. This is because umeclidinium in Trelegy Ellipta can cause difficulty urinating. Contact your prescriber if you notice difficulty urinating while using this medication.

                                        risk-warning

                                        Low potassium in the blood

                                        • Risk factors: Taking too much Trelegy Ellipta

                                          Trelegy Ellipta can sometimes cause the potassium levels in your blood to drop too low. This is more likely to happen if you take too much Trelegy Ellipta. Symptoms of low potassium include tiredness, weakness, muscle cramps, and a racing heart. Don't take more Trelegy Ellipta than prescribed. Seek medical help right away if Trelegy Ellipta isn't helping your breathing get better.

                                          dosage

                                          Trelegy Ellipta dosage forms

                                          The average cost for 1 inhaler of 60 blisters of 100mcg/62.5mcg/25mcg of Trelegy Ellipta is $661.11 with a free GoodRx coupon. This is 19.82% off the average retail price of $824.55.
                                          inhaler
                                          Inhaler
                                          DosageQuantityPrice as low asPrice per unit
                                          60 blisters of 100mcg/62.5mcg/25mcg1 inhaler$661.11$661.11
                                          60 blisters of 200mcg/62.5mcg/25mcg1 inhaler$644.11$644.11

                                          Typical dosing for Trelegy Ellipta

                                          COPD: The typical dose is 1 inhalation of 100 mcg/62.5 mcg/25 mcg (fluticasone/umeclidinium/vilanterol) by mouth once per day.

                                          • Asthma: The typical dose is 1 inhalation of 100 mcg/62.5 mcg/25 mcg or 200 mcg/62.5 mcg/25 mcg (fluticasone/umeclidinium/vilanterol) by mouth once per day.

                                          drug-cost

                                          How much does Trelegy Ellipta cost?

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                                          contraindications-icon

                                          Trelegy Ellipta contraindications

                                          Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Trelegy Ellipta will not be safe for you to take.
                                          • Treatment of sudden, severe asthma or COPD attack

                                          • Allergy to fluticasone (inhaled corticosteroid), umeclidinium (an anticholinergic), or vilanterol (long-acting beta agonist)

                                          • Allergy to lactose or milk proteins

                                          alternatives

                                          What are alternatives to Trelegy Ellipta?

                                          There are a number of medications that your doctor can prescribe in place of Trelegy Ellipta. Compare a few possible alternatives below.
                                          Trelegy Ellipta
                                          Used for:
                                          $644.11 Lowest GoodRx priceView Prices
                                          Used for:
                                          $656.26 Lowest GoodRx priceView Prices
                                          Used for:
                                          • Maintenance treatment of asthma in people ages 5 years and older

                                          $217.87 Lowest GoodRx priceView Prices
                                          images

                                          Trelegy Ellipta images

                                          white - TRELEGY ELLIPTA 100mcg-62.5mcg-25mcg / actuation Powder for Inhalation
                                          This medicine is White Inhaler.white - TRELEGY ELLIPTA 100mcg-62.5mcg-25mcg / actuation Powder for Inhalation

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                                          References

                                          Best studies we found
                                          View All References (8)

                                          Grant, A. C., et al. (2015). The ELLIPTA® dry powder inhaler: Design, functionality, in vitro dosing performance and critical task compliance by patients and caregivers. Journal of Aerosol Medicine and Pulmonary Drug Delivery.

                                          GSK. (2024). How to use Trelegy Ellipta.

                                          Korsgaard, J., et al. (2009). Potential side effects in patients treated with inhaled corticosteroids and long-acting beta2-agonists. Respiratory Medicine.

                                          MedlinePlus. (2016). Cushing’s syndrome.

                                          National Heart, Lung, and Blood Institute. (2012). Asthma care quick reference.

                                          National Institute for Health and Care Excellence (NICE). (2018). LAMA monotherapy. NICE Guideline.

                                          National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Symptoms & causes of adrenal insufficiency & Addison's disease.

                                          Saag, K. G., et al. (2024). Major side effects of inhaled glucocorticoids. UpToDate.

                                          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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