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Compare Incruse Ellipta vs. Trelegy Ellipta

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Incruse Ellipta (umeclidinium) and Trelegy Ellipta (fluticasone/umeclidinium/vilanterol) are both inhalers used for the maintenance treatment of chronic obstructive pulmonary disease (COPD), but they have some key differences. Incruse Ellipta contains only one medication, umeclidinium, which is a long-acting muscarinic antagonist (LAMA) that helps relax the muscles in your airways. Trelegy Ellipta, on the other hand, is a combination inhaler that includes three medications: fluticasone (an inhaled corticosteroid), umeclidinium (a LAMA), and vilanterol (a long-acting beta-2 agonist). This combination works together to reduce inflammation, relax airway muscles, and open up the airways. Trelegy Ellipta is also approved for asthma, while Incruse Ellipta is not. Additionally, you need to rinse your mouth after using Trelegy Ellipta to prevent fungal infections, a step that is not required with Incruse Ellipta. Both inhalers are used once daily, but Trelegy Ellipta offers a more comprehensive treatment by combining three medications in one.

  • Incruse ellipta (umeclidinium)
    Trelegy ellipta
  • Incruse ellipta (umeclidinium)
    Trelegy ellipta

  • Summary of Incruse Ellipta vs. Trelegy Ellipta

    Summary for LAMA
    Prescription only

    Incruse Ellipta (umeclidinium) is an long-acting muscarinic antagonist (LAMA). It's an inhaler used for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. Incruse Ellipta (umeclidinium) is inhaled through the mouth once per day. People who use Incruse Ellipta (umeclidinium) typically don't experience too many side effects, but ones reported include common cold symptoms, like sore throat and cough.

    Summary for ICS / LAMA / LABA
    Prescription only

    Trelegy Ellipta is a combination maintenance inhaler used to treat adults with chronic obstructive pulmonary disease (COPD) and asthma. It contains three active ingredients: fluticasone (a corticosteroid), umeclidinium (a long-acting muscarinic antagonist), and vilanterol (a long-acting beta agonist). Together, these help reduce airway inflammation, relax airway muscles, and help keep your airways open. The typical dose is one puff inhaled through the mouth once a day. Common side effects include headache, cough, and back pain.

  • Indications of Incruse Ellipta vs. Trelegy Ellipta

    Indications for
    •Maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults
    Indications for
    •Maintenance treatment of asthma
    •Maintenance treatment of chronic obstructive pulmonary disease (COPD)

  • Pros and Cons of Incruse Ellipta vs. Trelegy Ellipta

    Pros and Const for LAMA
    Pros
    •Inhaled once per day
    •Might be easier to use compared to some other dry powder inhalers
    •Can be stored at room temperature
    Cons
    •Can't use if you're severely allergic to milk proteins because it contains lactose
    •Not a rescue inhaler for sudden breathing problems
    •Brand-name medication only
    Pros and Const for ICS / LAMA / LABA
    Pros
    •Only need to inhale one puff once a day
    •Combination of three medications within a single inhaler
    •Approved for both COPD and asthma
    Cons
    •Common side effects include headache and cough
    •Can't use if severely allergic to milk proteins because it contains lactose
    •Need to rinse your mouth after each dose to prevent oral thrush

  • Common Side Effects of Incruse Ellipta vs. Trelegy Ellipta

    Common Side Effects for
    •Common cold (8%)
    •Upper respiratory tract infection (5%)
    •Cough (3%)
    •Joint pain (2%)
    Common Side Effects for

    COPD:

    •Headache (4%)
    •Back pain (4%)
    •Changes in taste (2%)
    •Diarrhea (2%)

    Asthma:

    •Common cold symptoms (up to 17%)
    •Headache (up to 9%)
    •Upper respiratory tract infection (up to 7%)
    •Bronchitis (up to 5%)
    •Sinus infection (up to 3%)
    •Back pain (up to 3%)

  • Warnings of Incruse Ellipta vs. Trelegy Ellipta

    Common Side Effects for
    •Not a rescue inhaler
    •Narrowing of your airways (bronchospasm)
    •Serious allergic reactions
    •Worsening narrow-angle glaucoma
    •Trouble urinating
    Common Side Effects for
    •Worsening symptoms or sudden flare-ups
    •Overdose
    •Oral thrush
    •Pneumonia
    •Risk of infection
    •Changes in stress hormone levels
    •Sudden narrowing of the airways
    •Serious allergic reaction
    •Heart problems
    •Weaker bones
    •Eye problems
    •Trouble urinating
    •Worsening of certain health conditions
    •Low potassium and high blood sugar

  • Prices with our coupons for Incruse Ellipta vs. Trelegy Ellipta

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